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Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle

Mastitis is one of the most serious diseases of dairy cattle, causing substantial financial losses. While predisposition to reduced somatic cell count in milk has been considered for in cattle breeding programs as the key indicator of udder health status, scientists are seeking genetic markers of in... Full description

Journal Title: Electronic Journal of Biotechnology July 2019, Vol.40, pp.17-21
Main Author: Pokorska, Joanna
Other Authors: Piestrzyńska-Kajtoch, Agata , Kułaj, Dominika , Ochrem, Andrzej , Radko, Anna
Format: Electronic Article Electronic Article
Language: English
Subjects:
Snp
Quelle: ScienceDirect Journals (Elsevier)
ID: ISSN: 0717-3458 ; E-ISSN: 0717-3458 ; DOI: 10.1016/j.ejbt.2019.04.004
Link: https://www.sciencedirect.com/science/article/pii/S071734581930020X
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recordid: elsevier_sdoi_10_1016_j_ejbt_2019_04_004
title: Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle
format: Article
creator:
  • Pokorska, Joanna
  • Piestrzyńska-Kajtoch, Agata
  • Kułaj, Dominika
  • Ochrem, Andrzej
  • Radko, Anna
subjects:
  • Alleles
  • Breeding
  • Cattle
  • Gene Polymorphism
  • Haplotype
  • Lipocalin-2
  • Mastitis
  • Milk
  • Snp
  • Somatic Cell Score
  • Udder
  • Engineering
ispartof: Electronic Journal of Biotechnology, July 2019, Vol.40, pp.17-21
description: Mastitis is one of the most serious diseases of dairy cattle, causing substantial financial losses. While predisposition to reduced somatic cell count in milk has been considered for in cattle breeding programs as the key indicator of udder health status, scientists are seeking genetic markers of innate immune response, which could be helpful in selecting cows with improved immunity to mastitis. Lipocalin-2 (LCN2) is a protein involved in the response of the immune system by eliminating iron ions which are necessary for the growth of pathogenic bacteria, so LCN2 may be considered as a natural bacteriostatic agent and could become a marker of infection. A total of five SNPs were identified in LCN2 gene (one in the promoter, three in exon 1, and one in intron 1). A single haplotype block was identified. The locus g.98793763G > C was found to have a significant impact on protein levels in milk, and alleles of this locus were identified to have a significant positive dominance effect on this trait. None of the four analysed loci had a statistically significant impact on the milk yield, fat levels in milk or the somatic cell score. LCN-2 gene had no significant impact on the incidence of mastitis in the cows. Although the identified SNPs were not found to have any impact on the somatic cell count or the incidence of mastitis in cows, it seems that further research is necessary, covering a larger population of cattle, to confirm the association between lipocalin-2 and milk production traits and mastitis. Pokorska J, Piestrzyńska-Kajtoch A, Kułaj D, et al. Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle. Electron J Biotechnol 2019;40.
language: eng
source: ScienceDirect Journals (Elsevier)
identifier: ISSN: 0717-3458 ; E-ISSN: 0717-3458 ; DOI: 10.1016/j.ejbt.2019.04.004
fulltext: fulltext
issn:
  • 0717-3458
  • 07173458
url: Link


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titlePolymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle
creatorPokorska, Joanna ; Piestrzyńska-Kajtoch, Agata ; Kułaj, Dominika ; Ochrem, Andrzej ; Radko, Anna
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subjectAlleles ; Breeding ; Cattle ; Gene Polymorphism ; Haplotype ; Lipocalin-2 ; Mastitis ; Milk ; Snp ; Somatic Cell Score ; Udder ; Engineering
descriptionMastitis is one of the most serious diseases of dairy cattle, causing substantial financial losses. While predisposition to reduced somatic cell count in milk has been considered for in cattle breeding programs as the key indicator of udder health status, scientists are seeking genetic markers of innate immune response, which could be helpful in selecting cows with improved immunity to mastitis. Lipocalin-2 (LCN2) is a protein involved in the response of the immune system by eliminating iron ions which are necessary for the growth of pathogenic bacteria, so LCN2 may be considered as a natural bacteriostatic agent and could become a marker of infection. A total of five SNPs were identified in LCN2 gene (one in the promoter, three in exon 1, and one in intron 1). A single haplotype block was identified. The locus g.98793763G > C was found to have a significant impact on protein levels in milk, and alleles of this locus were identified to have a significant positive dominance effect on this trait. None of the four analysed loci had a statistically significant impact on the milk yield, fat levels in milk or the somatic cell score. LCN-2 gene had no significant impact on the incidence of mastitis in the cows. Although the identified SNPs were not found to have any impact on the somatic cell count or the incidence of mastitis in cows, it seems that further research is necessary, covering a larger population of cattle, to confirm the association between lipocalin-2 and milk production traits and mastitis. Pokorska J, Piestrzyńska-Kajtoch A, Kułaj D, et al. Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle. Electron J Biotechnol 2019;40.
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