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Nicorandil attenuates cyclic strain-induced endothelin-1 expression via the induction of activating transcription factor 3 in human umbilical vein endothelial cells

Nicorandil is an adenosine triphosphate-sensitive potassium channel opener that combines an organic nitrate and a nicotinamide group which respectively confer to nicorandil the additional properties of being a nitric oxide (NO) donor and antioxidant; it also induces vasodilation, decreases the blood... Full description

Journal Title: European Journal of Pharmacology 2011, Vol.667(1), pp.292-297
Main Author: Chao, Hung-Hsing
Other Authors: Hong, Hong-Jye , Sung, Li-Chin , Chen, Jin-Jer , Cheng, Tzu-Hurng , Liu, Ju-Chi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0014-2999 ; E-ISSN: 1879-0712 ; DOI: 10.1016/j.ejphar.2011.05.062
Link: https://www.sciencedirect.com/science/article/pii/S0014299911006455
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recordid: elsevier_sdoi_10_1016_j_ejphar_2011_05_062
title: Nicorandil attenuates cyclic strain-induced endothelin-1 expression via the induction of activating transcription factor 3 in human umbilical vein endothelial cells
format: Article
creator:
  • Chao, Hung-Hsing
  • Hong, Hong-Jye
  • Sung, Li-Chin
  • Chen, Jin-Jer
  • Cheng, Tzu-Hurng
  • Liu, Ju-Chi
subjects:
  • Nicorandil
  • Cyclic Strain
  • Endothelin-1
  • Nitric Oxide
  • Activating Transcription Factor 3
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: European Journal of Pharmacology, 2011, Vol.667(1), pp.292-297
description: Nicorandil is an adenosine triphosphate-sensitive potassium channel opener that combines an organic nitrate and a nicotinamide group which respectively confer to nicorandil the additional properties of being a nitric oxide (NO) donor and antioxidant; it also induces vasodilation, decreases the blood pressure, and protects the heart. However, the intracellular mechanism of nicorandil remains to be delineated. The aims of this study were to test the hypothesis that nicorandil alters strain-induced endothelin-1 secretion and NO production, and to identify the putative underlying signaling pathways in human umbilical vein endothelial cells (HUVECs). Cultured HUVECs were exposed to cyclic strain in the presence of nicorandil; endothelin-1 expression was examined by reverse-transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay. Activation of extracellular signal-regulated protein kinase (ERK), endothelial NO synthase (eNOS), and activating transcription factor...
language: eng
source:
identifier: ISSN: 0014-2999 ; E-ISSN: 1879-0712 ; DOI: 10.1016/j.ejphar.2011.05.062
fulltext: fulltext
issn:
  • 0014-2999
  • 00142999
  • 1879-0712
  • 18790712
url: Link


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titleNicorandil attenuates cyclic strain-induced endothelin-1 expression via the induction of activating transcription factor 3 in human umbilical vein endothelial cells
creatorChao, Hung-Hsing ; Hong, Hong-Jye ; Sung, Li-Chin ; Chen, Jin-Jer ; Cheng, Tzu-Hurng ; Liu, Ju-Chi
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subjectNicorandil ; Cyclic Strain ; Endothelin-1 ; Nitric Oxide ; Activating Transcription Factor 3 ; Pharmacy, Therapeutics, & Pharmacology
descriptionNicorandil is an adenosine triphosphate-sensitive potassium channel opener that combines an organic nitrate and a nicotinamide group which respectively confer to nicorandil the additional properties of being a nitric oxide (NO) donor and antioxidant; it also induces vasodilation, decreases the blood pressure, and protects the heart. However, the intracellular mechanism of nicorandil remains to be delineated. The aims of this study were to test the hypothesis that nicorandil alters strain-induced endothelin-1 secretion and NO production, and to identify the putative underlying signaling pathways in human umbilical vein endothelial cells (HUVECs). Cultured HUVECs were exposed to cyclic strain in the presence of nicorandil; endothelin-1 expression was examined by reverse-transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay. Activation of extracellular signal-regulated protein kinase (ERK), endothelial NO synthase (eNOS), and activating transcription factor...
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titleNicorandil attenuates cyclic strain-induced endothelin-1 expression via the induction of activating transcription factor 3 in human umbilical vein endothelial cells
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Nicorandil is an adenosine triphosphate-sensitive potassium channel opener that combines an organic nitrate and a nicotinamide group which respectively confer to nicorandil the additional properties of being a nitric oxide (NO) donor and antioxidant; it also induces vasodilation, decreases the blood pressure, and protects the heart. However, the intracellular mechanism of nicorandil remains to be delineated. The aims of this study were to test the hypothesis that nicorandil alters strain-induced endothelin-1 secretion and NO production, and to identify the putative underlying signaling pathways in human umbilical vein endothelial cells (HUVECs). Cultured HUVECs were exposed to cyclic strain in the presence of nicorandil; endothelin-1 expression was examined by reverse-transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay. Activation of extracellular signal-regulated protein kinase (ERK), endothelial NO synthase (eNOS), and activating transcription factor...

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abstract

Nicorandil is an adenosine triphosphate-sensitive potassium channel opener that combines an organic nitrate and a nicotinamide group which respectively confer to nicorandil the additional properties of being a nitric oxide (NO) donor and antioxidant; it also induces vasodilation, decreases the blood pressure, and protects the heart. However, the intracellular mechanism of nicorandil remains to be delineated. The aims of this study were to test the hypothesis that nicorandil alters strain-induced endothelin-1 secretion and NO production, and to identify the putative underlying signaling pathways in human umbilical vein endothelial cells (HUVECs). Cultured HUVECs were exposed to cyclic strain in the presence of nicorandil; endothelin-1 expression was examined by reverse-transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay. Activation of extracellular signal-regulated protein kinase (ERK), endothelial NO synthase (eNOS), and activating transcription factor...

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lad01European Journal of Pharmacology
date2011-09-30