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Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: Role of GLP-1 and GLP-1 receptor

The present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. Hypertension was induced in adult rats by administration of L-NAME for 6 w... Full description

Journal Title: European Journal of Pharmacology 15 November 2013, Vol.720(1-3), pp.158-165
Main Author: Abd El Motteleb, Dalia M
Other Authors: Elshazly, Shimaa M
Format: Electronic Article Electronic Article
Language: English
Subjects:
MDA
ID: ISSN: 0014-2999 ; E-ISSN: 1879-0712 ; DOI: 10.1016/j.ejphar.2013.10.033
Link: https://www.sciencedirect.com/science/article/pii/S0014299913007929
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recordid: elsevier_sdoi_10_1016_j_ejphar_2013_10_033
title: Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: Role of GLP-1 and GLP-1 receptor
format: Article
creator:
  • Abd El Motteleb, Dalia M
  • Elshazly, Shimaa M
subjects:
  • Glp-1 Receptor
  • L-Name
  • MDA
  • Nephropathy
  • Sitagliptin
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: European Journal of Pharmacology, 15 November 2013, Vol.720(1-3), pp.158-165
description: The present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. Hypertension was induced in adult rats by administration of L-NAME for 6 weeks. Rats were treated with sitagliptin (10 mg/kg/day or 30 mg/kg/day) for six weeks. Chronic L-NAME administration resulted in depletion of serum nitric oxide (NO) associated with elevation in the mean arterial pressure. When compared with the control group; serum urea, serum creatinine, albuminuria, urinary -acetyl- - -glucosaminidase (NAG) level and renal tissue malondialdhyde (MDA) content were significantly elevated, while creatinine clearance, serum level of glucagon like peptide-1 (GLP-1) as well as renal tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities...
language: eng
source:
identifier: ISSN: 0014-2999 ; E-ISSN: 1879-0712 ; DOI: 10.1016/j.ejphar.2013.10.033
fulltext: fulltext
issn:
  • 0014-2999
  • 00142999
  • 1879-0712
  • 18790712
url: Link


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titleRenoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: Role of GLP-1 and GLP-1 receptor
creatorAbd El Motteleb, Dalia M ; Elshazly, Shimaa M
ispartofEuropean Journal of Pharmacology, 15 November 2013, Vol.720(1-3), pp.158-165
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subjectGlp-1 Receptor ; L-Name ; MDA ; Nephropathy ; Sitagliptin ; Pharmacy, Therapeutics, & Pharmacology
descriptionThe present study was undertaken to assess the possible protective effects of sitagliptin, a dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) induced hypertensive nephropathy in rats. Hypertension was induced in adult rats by administration of L-NAME for 6 weeks. Rats were treated with sitagliptin (10 mg/kg/day or 30 mg/kg/day) for six weeks. Chronic L-NAME administration resulted in depletion of serum nitric oxide (NO) associated with elevation in the mean arterial pressure. When compared with the control group; serum urea, serum creatinine, albuminuria, urinary -acetyl- - -glucosaminidase (NAG) level and renal tissue malondialdhyde (MDA) content were significantly elevated, while creatinine clearance, serum level of glucagon like peptide-1 (GLP-1) as well as renal tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities...
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