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Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: Replication and extension of a gene–environment interaction

A previous study reported that social stress sensitivity is moderated by the brain-derived-neurotrophic-factor (BDNF rs6265) genotype. Additionally, positive emotions partially neutralize this moderating effect. The current study aimed to: (i) replicate in a new independent sample of subjects with r... Full description

Journal Title: European Neuropsychopharmacology June 2014, Vol.24(6), pp.930-938
Main Author: van Winkel, Mark
Other Authors: Peeters, Frenk , van Winkel, Ruud , Kenis, Gunter , Collip, Dina , Geschwind, Nicole , Jacobs, Nele , Derom, Catherine , Thiery, Evert , van Os, Jim , Myin-Germeys, Inez , Wichers, Marieke
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0924-977X ; E-ISSN: 1873-7862 ; DOI: 10.1016/j.euroneuro.2014.02.005
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recordid: elsevier_sdoi_10_1016_j_euroneuro_2014_02_005
title: Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: Replication and extension of a gene–environment interaction
format: Article
creator:
  • van Winkel, Mark
  • Peeters, Frenk
  • van Winkel, Ruud
  • Kenis, Gunter
  • Collip, Dina
  • Geschwind, Nicole
  • Jacobs, Nele
  • Derom, Catherine
  • Thiery, Evert
  • van Os, Jim
  • Myin-Germeys, Inez
  • Wichers, Marieke
subjects:
  • Bdnf Genotype
  • Gene–Environment Interaction
  • Stress Sensitivity
  • Experience Sampling Method (Esm)
  • Positive Emotions
  • Major Depressive Disorder (Mdd)
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: European Neuropsychopharmacology, June 2014, Vol.24(6), pp.930-938
description: A previous study reported that social stress sensitivity is moderated by the brain-derived-neurotrophic-factor (BDNF rs6265) genotype. Additionally, positive emotions partially neutralize this moderating effect. The current study aimed to: (i) replicate in a new independent sample of subjects with residual depressive symptoms the moderating effect of BDNF genotype on social stress sensitivity, (ii) replicate the neutralizing impact of positive emotions, (iii) extend these analyses to other variations in the BDNF gene in the new independent sample and the original sample of non-depressed individuals. Previous findings were replicated in an experience sampling method (ESM) study. Negative Affect (NA) responses to social stress were stronger in “Val/Met” carriers of BDNF compared to “Val/Val” carriers. Positive emotions neutralized the moderating effect of BDNF genotype on social stress...
language: eng
source:
identifier: ISSN: 0924-977X ; E-ISSN: 1873-7862 ; DOI: 10.1016/j.euroneuro.2014.02.005
fulltext: fulltext
issn:
  • 0924-977X
  • 0924977X
  • 1873-7862
  • 18737862
url: Link


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titleImpact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: Replication and extension of a gene–environment interaction
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subjectBdnf Genotype ; Gene–Environment Interaction ; Stress Sensitivity ; Experience Sampling Method (Esm) ; Positive Emotions ; Major Depressive Disorder (Mdd) ; Pharmacy, Therapeutics, & Pharmacology
descriptionA previous study reported that social stress sensitivity is moderated by the brain-derived-neurotrophic-factor (BDNF rs6265) genotype. Additionally, positive emotions partially neutralize this moderating effect. The current study aimed to: (i) replicate in a new independent sample of subjects with residual depressive symptoms the moderating effect of BDNF genotype on social stress sensitivity, (ii) replicate the neutralizing impact of positive emotions, (iii) extend these analyses to other variations in the BDNF gene in the new independent sample and the original sample of non-depressed individuals. Previous findings were replicated in an experience sampling method (ESM) study. Negative Affect (NA) responses to social stress were stronger in “Val/Met” carriers of BDNF compared to “Val/Val” carriers. Positive emotions neutralized the moderating effect of BDNF genotype on social stress...
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