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The Impact of Low Serum Sodium on Treatment Outcome of Targeted Therapy in Metastatic Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Cancer Database Consortium

Hyponatremia has been associated with poor survival in many solid tumors and more recently found to be of prognostic and predictive value in metastatic renal cell cancer (mRCC) patients treated with immunotherapy. To investigate the influence of baseline hyponatremia in mRCC patients treated with ta... Full description

Journal Title: European Urology April 2014, Vol.65(4), pp.723-730
Main Author: Schutz, Fabio A.B
Other Authors: Xie, Wanling , Donskov, Frede , Sircar, Monica , Mcdermott, David F , Rini, Brian I , Agarwal, Neeraj , Pal, Sumanta Kumar , Srinivas, Sandy , Kollmannsberger, Christian , North, Scott A , Wood, Lori A , Vaishampayan, Ulka , Tan, Min-Han , Mackenzie, Mary J , Lee, Jae Lyun , Rha, Sun-Young , Yuasa, Takeshi , Heng, Daniel Y.C , Choueiri, Toni K
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0302-2838 ; E-ISSN: 1873-7560 ; DOI: 10.1016/j.eururo.2013.10.013
Link: https://www.sciencedirect.com/science/article/pii/S0302283813010865
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recordid: elsevier_sdoi_10_1016_j_eururo_2013_10_013
title: The Impact of Low Serum Sodium on Treatment Outcome of Targeted Therapy in Metastatic Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Cancer Database Consortium
format: Article
creator:
  • Schutz, Fabio A.B
  • Xie, Wanling
  • Donskov, Frede
  • Sircar, Monica
  • Mcdermott, David F
  • Rini, Brian I
  • Agarwal, Neeraj
  • Pal, Sumanta Kumar
  • Srinivas, Sandy
  • Kollmannsberger, Christian
  • North, Scott A
  • Wood, Lori A
  • Vaishampayan, Ulka
  • Tan, Min-Han
  • Mackenzie, Mary J
  • Lee, Jae Lyun
  • Rha, Sun-Young
  • Yuasa, Takeshi
  • Heng, Daniel Y.C
  • Choueiri, Toni K
subjects:
  • Hyponatremia
  • Renal Cell Cancer
  • Anti-Vegf
  • Prognostic Factors
  • Medicine
ispartof: European Urology, April 2014, Vol.65(4), pp.723-730
description: Hyponatremia has been associated with poor survival in many solid tumors and more recently found to be of prognostic and predictive value in metastatic renal cell cancer (mRCC) patients treated with immunotherapy. To investigate the influence of baseline hyponatremia in mRCC patients treated with targeted therapy in the International Metastatic Renal Cell Carcinoma Database Consortium. Data on 1661 patients treated with first-line vascular endothelial growth factor (VEGF) or mammalian target of rapamycin (mTOR) targeted therapy for mRCC were available from 18 cancer centers to study the impact of hyponatremia (serum sodium level
language: eng
source:
identifier: ISSN: 0302-2838 ; E-ISSN: 1873-7560 ; DOI: 10.1016/j.eururo.2013.10.013
fulltext: fulltext
issn:
  • 0302-2838
  • 03022838
  • 1873-7560
  • 18737560
url: Link


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titleThe Impact of Low Serum Sodium on Treatment Outcome of Targeted Therapy in Metastatic Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Cancer Database Consortium
creatorSchutz, Fabio A.B ; Xie, Wanling ; Donskov, Frede ; Sircar, Monica ; Mcdermott, David F ; Rini, Brian I ; Agarwal, Neeraj ; Pal, Sumanta Kumar ; Srinivas, Sandy ; Kollmannsberger, Christian ; North, Scott A ; Wood, Lori A ; Vaishampayan, Ulka ; Tan, Min-Han ; Mackenzie, Mary J ; Lee, Jae Lyun ; Rha, Sun-Young ; Yuasa, Takeshi ; Heng, Daniel Y.C ; Choueiri, Toni K
ispartofEuropean Urology, April 2014, Vol.65(4), pp.723-730
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subjectHyponatremia ; Renal Cell Cancer ; Anti-Vegf ; Prognostic Factors ; Medicine
descriptionHyponatremia has been associated with poor survival in many solid tumors and more recently found to be of prognostic and predictive value in metastatic renal cell cancer (mRCC) patients treated with immunotherapy. To investigate the influence of baseline hyponatremia in mRCC patients treated with targeted therapy in the International Metastatic Renal Cell Carcinoma Database Consortium. Data on 1661 patients treated with first-line vascular endothelial growth factor (VEGF) or mammalian target of rapamycin (mTOR) targeted therapy for mRCC were available from 18 cancer centers to study the impact of hyponatremia (serum sodium level <135 mmol/l) on clinical outcomes. The primary objective was overall survival (OS) and secondary end points included time to treatment failure (TTF) and the disease control rate (DCR). The chi-square test was used to compare the DCR in patients with and without hyponatremia. OS and TTF were estimated...
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