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MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway

MiR-222 in glioma can regulate cell cycle progression and apoptosis. However, the relationship between miR-222 and Wnt/β-catenin signaling pathway in glioma remains unknown. Here, we found that the Dickkopf-2 gene ( ) was a direct target of miR-222 by target prediction analysis and dual luciferase r... Full description

Journal Title: FEBS Letters 19 June 2013, Vol.587(12), pp.1742-1748
Main Author: Li, Qifeng
Other Authors: Shen, Ke , Zhao, Yang , He, Xiaoguang , Ma, Chenkai , Wang, Lin , Wang, Baocheng , Liu, Jianwen , Ma, Jie
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0014-5793 ; E-ISSN: 1873-3468 ; DOI: 10.1016/j.febslet.2013.04.002
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recordid: elsevier_sdoi_10_1016_j_febslet_2013_04_002
title: MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway
format: Article
creator:
  • Li, Qifeng
  • Shen, Ke
  • Zhao, Yang
  • He, Xiaoguang
  • Ma, Chenkai
  • Wang, Lin
  • Wang, Baocheng
  • Liu, Jianwen
  • Ma, Jie
subjects:
  • Mir-222
  • Dkk2
  • Wnt/Β-Catenin Signaling Pathway
  • Glioma
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: FEBS Letters, 19 June 2013, Vol.587(12), pp.1742-1748
description: MiR-222 in glioma can regulate cell cycle progression and apoptosis. However, the relationship between miR-222 and Wnt/β-catenin signaling pathway in glioma remains unknown. Here, we found that the Dickkopf-2 gene ( ) was a direct target of miR-222 by target prediction analysis and dual luciferase reporter assay. RNA interference silencing of proved that miR-222 overexpression led to constitutive activation of β-catenin through inhibition of expression in glioma cells. Furthermore, miR-222 siRNA significantly inhibited tumorigenesis in vivo. Finally, Western blot analysis showed that miR-222 could regulate the expression of β-catenin and the downstream genes of Wnt/β-catenin signaling pathway. Taken together, our findings reveal a new regulatory mechanism of miR-222 and suggest that miR-222 might be a potential target in glioma therapy.
language: eng
source:
identifier: ISSN: 0014-5793 ; E-ISSN: 1873-3468 ; DOI: 10.1016/j.febslet.2013.04.002
fulltext: fulltext
issn:
  • 0014-5793
  • 00145793
  • 1873-3468
  • 18733468
url: Link


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descriptionMiR-222 in glioma can regulate cell cycle progression and apoptosis. However, the relationship between miR-222 and Wnt/β-catenin signaling pathway in glioma remains unknown. Here, we found that the Dickkopf-2 gene ( ) was a direct target of miR-222 by target prediction analysis and dual luciferase reporter assay. RNA interference silencing of proved that miR-222 overexpression led to constitutive activation of β-catenin through inhibition of expression in glioma cells. Furthermore, miR-222 siRNA significantly inhibited tumorigenesis in vivo. Finally, Western blot analysis showed that miR-222 could regulate the expression of β-catenin and the downstream genes of Wnt/β-catenin signaling pathway. Taken together, our findings reveal a new regulatory mechanism of miR-222 and suggest that miR-222 might be a potential target in glioma therapy.
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