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Markedly elevated soluble E-cadherin in plasma of patient with pelvic inflammatory disease

To estimate the expression of plasma soluble E-cadherin and the gene polymorphism in patients with pelvic inflammatory disease (PID). Hospital-based case–control study. University hospital. Sixty-four women with PID. Blood specimen collection from patients before and after they received treatment. E... Full description

Journal Title: Fertility and Sterility February 2013, Vol.99(2), pp.490-495
Main Author: Tsai, Hsiu-Ting
Other Authors: Lee, Tsung-Hsien , Yang, Shun-Fa , Lin, Long-Yau , Tee, Yi-Torng , Wang, Po-Hui
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0015-0282 ; E-ISSN: 1556-5653 ; DOI: 10.1016/j.fertnstert.2012.10.010
Link: https://www.sciencedirect.com/science/article/pii/S0015028212023102
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recordid: elsevier_sdoi_10_1016_j_fertnstert_2012_10_010
title: Markedly elevated soluble E-cadherin in plasma of patient with pelvic inflammatory disease
format: Article
creator:
  • Tsai, Hsiu-Ting
  • Lee, Tsung-Hsien
  • Yang, Shun-Fa
  • Lin, Long-Yau
  • Tee, Yi-Torng
  • Wang, Po-Hui
subjects:
  • E-Cadherin
  • Single Nucleotide Polymorphism (Snp)
  • Pelvic Inflammatory Disease (PID)
  • Medicine
ispartof: Fertility and Sterility, February 2013, Vol.99(2), pp.490-495
description: To estimate the expression of plasma soluble E-cadherin and the gene polymorphism in patients with pelvic inflammatory disease (PID). Hospital-based case–control study. University hospital. Sixty-four women with PID. Blood specimen collection from patients before and after they received treatment. Enzyme-linked immunosorbent assay and polymerase chain reaction–restriction fragment length polymorphism were respectively used to measure the plasma soluble E-cadherin level and E-cadherin polymorphism. The level of plasma E-cadherin was significantly elevated in patients with PID as compared with that in normal controls; it decreased significantly after treatment when compared with levels noted in the same patients before they received treatment. When the cutoff level of plasma E-cadherin level was set to 20.22 ng/mL on the basis of receiver-operating characteristic curve (ROC), the sensitivity, specificity, and the area under the curve of plasma E-cadherin level for predicting PID were 0.81, 0.80, and 0.835 (95% confidence interval 0.76–0.90), respectively. The adjusted odds ratio for age, white blood cell count, and C-reactive protein levels was 19.66 (5.48–70.47). Elevated plasma soluble E-cadherin expression was involved in the pathogenesis of PID and is useful for the diagnosis of PID.
language: eng
source:
identifier: ISSN: 0015-0282 ; E-ISSN: 1556-5653 ; DOI: 10.1016/j.fertnstert.2012.10.010
fulltext: fulltext
issn:
  • 0015-0282
  • 00150282
  • 1556-5653
  • 15565653
url: Link


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titleMarkedly elevated soluble E-cadherin in plasma of patient with pelvic inflammatory disease
creatorTsai, Hsiu-Ting ; Lee, Tsung-Hsien ; Yang, Shun-Fa ; Lin, Long-Yau ; Tee, Yi-Torng ; Wang, Po-Hui
ispartofFertility and Sterility, February 2013, Vol.99(2), pp.490-495
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subjectE-Cadherin ; Single Nucleotide Polymorphism (Snp) ; Pelvic Inflammatory Disease (PID) ; Medicine
descriptionTo estimate the expression of plasma soluble E-cadherin and the gene polymorphism in patients with pelvic inflammatory disease (PID). Hospital-based case–control study. University hospital. Sixty-four women with PID. Blood specimen collection from patients before and after they received treatment. Enzyme-linked immunosorbent assay and polymerase chain reaction–restriction fragment length polymorphism were respectively used to measure the plasma soluble E-cadherin level and E-cadherin polymorphism. The level of plasma E-cadherin was significantly elevated in patients with PID as compared with that in normal controls; it decreased significantly after treatment when compared with levels noted in the same patients before they received treatment. When the cutoff level of plasma E-cadherin level was set to 20.22 ng/mL on the basis of receiver-operating characteristic curve (ROC), the sensitivity, specificity, and the area under the curve of plasma E-cadherin level for predicting PID were 0.81, 0.80, and 0.835 (95% confidence interval 0.76–0.90), respectively. The adjusted odds ratio for age, white blood cell count, and C-reactive protein levels was 19.66 (5.48–70.47). Elevated plasma soluble E-cadherin expression was involved in the pathogenesis of PID and is useful for the diagnosis of PID.
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