schliessen

Filtern

 

Bibliotheken

Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort

There is an ongoing discussion on whether serum uric acid (SUA) predicts ischemic heart disease (IHD) independently of other metabolic factors, which, if confirmed, would signify a role for uric acid in the pathogenesis of cardiovascular disease. We investigated whether such a relation exists for et... Full description

Journal Title: International Journal of Cardiology 2012, Vol.154(3), pp.316-321
Main Author: Chuang, Shao-Yuan
Other Authors: Chen, Jiunn-Horng , Yeh, Wen-Ting , Wu, Chih-Cheng , Pan, Wen-Harn
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0167-5273 ; E-ISSN: 1874-1754 ; DOI: 10.1016/j.ijcard.2011.06.055
Link: https://www.sciencedirect.com/science/article/pii/S0167527311005808
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_ijcard_2011_06_055
title: Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort
format: Article
creator:
  • Chuang, Shao-Yuan
  • Chen, Jiunn-Horng
  • Yeh, Wen-Ting
  • Wu, Chih-Cheng
  • Pan, Wen-Harn
subjects:
  • Uric Acid
  • Ischemic Heart Disease
  • Prospective Study
  • Chinese
  • Medicine
ispartof: International Journal of Cardiology, 2012, Vol.154(3), pp.316-321
description: There is an ongoing discussion on whether serum uric acid (SUA) predicts ischemic heart disease (IHD) independently of other metabolic factors, which, if confirmed, would signify a role for uric acid in the pathogenesis of cardiovascular disease. We investigated whether such a relation exists for ethnic Chinese with low CVD risk. Enrolled, between 1994 and 1996, were 128,569 adults ≥ 20 years from four ‘MJ’ Health Check-up Clinics in Taiwan. Excluded were those with heart disease, previous stroke(s), renal disease, and/or cancer. Physical examinations, biospecimen collections, and structured questionnaires were executed according to standardised protocols. We identified IHD events according to the ICD-9-CM codes 410–414 using hospitalisation records obtained from the National Health Insurance and the Death Certification Registry databases. The Cox proportional hazard model was used to estimate the hazard ratios (HRs) between SUA and IHD events. A total of 2049 subjects (1239 men, 810 women) developed IHD from baseline to Dec. 31, 2002. Men had a higher IHD incidence than did women (2.84 vs. 1.61 1/1000 person-years; p < 0.0001). The risk-factor-adjusted HRs (95% confidence-interval [CI]) for hyperuricemiae (SUA ≥ 7.0/≥6.0 mg/dL) were 1.25 (1.11–1.40) for men and 1.19 (1.02–1.38) for women. In the low-risk population (lacking the NCEP-ATPIII metabolic syndrome components), a significant association was still observed (adjusted HR: 1.54 [1.09–2.17]). The hyperuricemia was independently associated with the development of IHD not only in the general population but also in those without any metabolic risk factor for NCEP ATPIII. Hyperuricemia may be considered as a potential risk factor for IHD.
language: eng
source:
identifier: ISSN: 0167-5273 ; E-ISSN: 1874-1754 ; DOI: 10.1016/j.ijcard.2011.06.055
fulltext: fulltext
issn:
  • 0167-5273
  • 01675273
  • 1874-1754
  • 18741754
url: Link


@attributes
ID1716526391
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_ijcard_2011_06_055
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_ijcard_2011_06_055
sourcesystemOther
dbid
0--K
1--M
2.FO
3.~1
40SF
51B1
61P~
71RT
81~.
9457
104G.
117-5
128P~
139JM
14AABNK
15AAEDT
16AAKOC
17AAOAW
18AAQFI
19ABBQC
20ABFNM
21ABMZM
22ABYKQ
23ACDAQ
24ACIUM
25ACRLP
26AEKER
27AEVXI
28AFKWA
29AFTJW
30AFXIZ
31AGHFR
32AGUBO
33AGYEJ
34AHHHB
35AIKHN
36AITUG
37AJBFU
38AJOXV
39AJRQY
40AJUYK
41AMFUW
42ANZVX
43BLXMC
44BNPGV
45EO8
46EO9
47EP2
48EP3
49FDB
50FGOYB
51FIRID
52FNPLU
53G-Q
54GBLVA
55HEB
56HMK
57HMO
58J1W
59KOM
60LCYCR
61OA.
62OAUVE
63OL~
64P-8
65P-9
66PC.
67Q38
68R2-
69RPZ
70SAE
71SCC
72SDF
73SDG
74SEL
75SES
76SEW
77SSH
78SSZ
79T5K
80UV1
81Z5R
82~G-
pqid917159870
galeid277730720
display
typearticle
titleHyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort
creatorChuang, Shao-Yuan ; Chen, Jiunn-Horng ; Yeh, Wen-Ting ; Wu, Chih-Cheng ; Pan, Wen-Harn
ispartofInternational Journal of Cardiology, 2012, Vol.154(3), pp.316-321
identifier
subjectUric Acid ; Ischemic Heart Disease ; Prospective Study ; Chinese ; Medicine
descriptionThere is an ongoing discussion on whether serum uric acid (SUA) predicts ischemic heart disease (IHD) independently of other metabolic factors, which, if confirmed, would signify a role for uric acid in the pathogenesis of cardiovascular disease. We investigated whether such a relation exists for ethnic Chinese with low CVD risk. Enrolled, between 1994 and 1996, were 128,569 adults ≥ 20 years from four ‘MJ’ Health Check-up Clinics in Taiwan. Excluded were those with heart disease, previous stroke(s), renal disease, and/or cancer. Physical examinations, biospecimen collections, and structured questionnaires were executed according to standardised protocols. We identified IHD events according to the ICD-9-CM codes 410–414 using hospitalisation records obtained from the National Health Insurance and the Death Certification Registry databases. The Cox proportional hazard model was used to estimate the hazard ratios (HRs) between SUA and IHD events. A total of 2049 subjects (1239 men, 810 women) developed IHD from baseline to Dec. 31, 2002. Men had a higher IHD incidence than did women (2.84 vs. 1.61 1/1000 person-years; p < 0.0001). The risk-factor-adjusted HRs (95% confidence-interval [CI]) for hyperuricemiae (SUA ≥ 7.0/≥6.0 mg/dL) were 1.25 (1.11–1.40) for men and 1.19 (1.02–1.38) for women. In the low-risk population (lacking the NCEP-ATPIII metabolic syndrome components), a significant association was still observed (adjusted HR: 1.54 [1.09–2.17]). The hyperuricemia was independently associated with the development of IHD not only in the general population but also in those without any metabolic risk factor for NCEP ATPIII. Hyperuricemia may be considered as a potential risk factor for IHD.
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527311005808$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Chuang, Shao-Yuan
1Chen, Jiunn-Horng
2Yeh, Wen-Ting
3Wu, Chih-Cheng
4Pan, Wen-Harn
titleHyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort
description
subject
0Uric Acid
1Ischemic Heart Disease
2Prospective Study
3Chinese
4Medicine
general
0English
1Elsevier Ireland Ltd
210.1016/j.ijcard.2011.06.055
3ScienceDirect (Elsevier B.V.)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_ijcard_2011_06_055
issn
00167-5273
101675273
21874-1754
318741754
rsrctypearticle
creationdate2012
addtitleInternational Journal of Cardiology
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
40SF
51B1
61P~
71RT
81~.
9457
104G.
117-5
128P~
139JM
14AABNK
15AAEDT
16AAKOC
17AAOAW
18AAQFI
19ABBQC
20ABFNM
21ABMZM
22ABYKQ
23ACDAQ
24ACIUM
25ACRLP
26AEKER
27AEVXI
28AFKWA
29AFTJW
30AFXIZ
31AGHFR
32AGUBO
33AGYEJ
34AHHHB
35AIKHN
36AITUG
37AJBFU
38AJOXV
39AJRQY
40AJUYK
41AMFUW
42ANZVX
43BLXMC
44BNPGV
45EO8
46EO9
47EP2
48EP3
49FDB
50FGOYB
51FIRID
52FNPLU
53G-Q
54GBLVA
55HEB
56HMK
57HMO
58J1W
59KOM
60LCYCR
61OA.
62OAUVE
63OL~
64P-8
65P-9
66PC.
67Q38
68R2-
69RPZ
70SAE
71SCC
72SDF
73SDG
74SEL
75SES
76SEW
77SSH
78SSZ
79T5K
80UV1
81Z5R
82~G-
startdate20120101
enddate20121231
lsr40International Journal of Cardiology, 2012, Vol.154 (3), pp.316-321
doi10.1016/j.ijcard.2011.06.055
citationpf 316 pt 321 vol 154 issue 3
lsr30VSR-Enriched:[galeid, date, pqid]
sort
titleHyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort
authorChuang, Shao-Yuan ; Chen, Jiunn-Horng ; Yeh, Wen-Ting ; Wu, Chih-Cheng ; Pan, Wen-Harn
creationdate20120000
lso0120120000
facets
frbrgroupid7910534527264761932
frbrtype5
newrecords20190904
languageeng
topic
0Uric Acid
1Ischemic Heart Disease
2Prospective Study
3Chinese
4Medicine
collectionScienceDirect (Elsevier B.V.)
prefilterarticles
rsrctypearticles
creatorcontrib
0Chuang, Shao-Yuan
1Chen, Jiunn-Horng
2Yeh, Wen-Ting
3Wu, Chih-Cheng
4Pan, Wen-Harn
jtitleInternational Journal of Cardiology
creationdate2012
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Chuang
1Chen
2Yeh
3Wu
4Pan
aufirst
0Shao-Yuan
1Jiunn-Horng
2Wen-Ting
3Chih-Cheng
4Wen-Harn
auinitS
auinit1S
au
0Chuang, Shao-Yuan
1Chen, Jiunn-Horng
2Yeh, Wen-Ting
3Wu, Chih-Cheng
4Pan, Wen-Harn
atitleHyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort
jtitleInternational Journal of Cardiology
risdate2012
volume154
issue3
spage316
epage321
pages316-321
issn0167-5273
eissn1874-1754
formatjournal
genrearticle
ristypeJOUR
abstract
pubElsevier Ireland Ltd
doi10.1016/j.ijcard.2011.06.055
lad01International Journal of Cardiology
date2012-02-09