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Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome

To determine whether low molecular weight heparin (LMWH) plus low-dose aspirin (LDA) is comparable in efficacy and safety to unfractionated heparin (UFH) plus LDA in the management of pregnant women with a history of recurrent spontaneous abortion secondary to antiphospholipid syndrome (APS). In a r... Full description

Journal Title: International Journal of Gynecology and Obstetrics 2011, Vol.112(3), pp.211-215
Main Author: Fouda, Usama M
Other Authors: Sayed, Ahmed M , Abdou, Abdel-Megid A , Ramadan, Dalia I , Fouda, Iman M , Zaki, Mahmoud M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0020-7292 ; E-ISSN: 1879-3479 ; DOI: 10.1016/j.ijgo.2010.09.010
Link: https://www.sciencedirect.com/science/article/pii/S0020729210005382
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recordid: elsevier_sdoi_10_1016_j_ijgo_2010_09_010
title: Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome
format: Article
creator:
  • Fouda, Usama M
  • Sayed, Ahmed M
  • Abdou, Abdel-Megid A
  • Ramadan, Dalia I
  • Fouda, Iman M
  • Zaki, Mahmoud M
subjects:
  • Antiphospholipid Syndrome
  • Enoxaparin
  • Low Molecular Weight Heparin
  • Recurrent Abortion
  • Unfractionated Heparin
  • Medicine
ispartof: International Journal of Gynecology and Obstetrics, 2011, Vol.112(3), pp.211-215
description: To determine whether low molecular weight heparin (LMWH) plus low-dose aspirin (LDA) is comparable in efficacy and safety to unfractionated heparin (UFH) plus LDA in the management of pregnant women with a history of recurrent spontaneous abortion secondary to antiphospholipid syndrome (APS). In a randomized prospective study, 60 women with a history of 3 or more consecutive spontaneous abortions and positive antiphospholipid antibodies were assigned in equal numbers to receive either UFH (5000 units, twice daily) plus LDA, or LMWH (enoxaparin 40 mg, once daily) plus LDA as soon as pregnancy was diagnosed. Twenty-four women in the LMWH group (80%) and 20 women in the UFH group (66.67%) delivered a viable infant ( = 0.243). There were no significant differences in pregnancy complications or neonatal morbidity between the 2 groups. There were no...
language: eng
source:
identifier: ISSN: 0020-7292 ; E-ISSN: 1879-3479 ; DOI: 10.1016/j.ijgo.2010.09.010
fulltext: fulltext
issn:
  • 0020-7292
  • 00207292
  • 1879-3479
  • 18793479
url: Link


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titleEnoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome
creatorFouda, Usama M ; Sayed, Ahmed M ; Abdou, Abdel-Megid A ; Ramadan, Dalia I ; Fouda, Iman M ; Zaki, Mahmoud M
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subjectAntiphospholipid Syndrome ; Enoxaparin ; Low Molecular Weight Heparin ; Recurrent Abortion ; Unfractionated Heparin ; Medicine
descriptionTo determine whether low molecular weight heparin (LMWH) plus low-dose aspirin (LDA) is comparable in efficacy and safety to unfractionated heparin (UFH) plus LDA in the management of pregnant women with a history of recurrent spontaneous abortion secondary to antiphospholipid syndrome (APS). In a randomized prospective study, 60 women with a history of 3 or more consecutive spontaneous abortions and positive antiphospholipid antibodies were assigned in equal numbers to receive either UFH (5000 units, twice daily) plus LDA, or LMWH (enoxaparin 40 mg, once daily) plus LDA as soon as pregnancy was diagnosed. Twenty-four women in the LMWH group (80%) and 20 women in the UFH group (66.67%) delivered a viable infant ( = 0.243). There were no significant differences in pregnancy complications or neonatal morbidity between the 2 groups. There were no...
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