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Rationale for and Preliminary Results of Proton Beam Therapy for Mediastinal Lymphoma

To evaluate the potential of three-dimensional proton beam therapy (3D-PBT) for reducing doses to normal structures in patients with mediastinal lymphomas compared with conventional photon radiation therapy (RT). We treated 10 consecutive patients with mediastinal masses from lymphomas with 3D-PBT b... Full description

Journal Title: International Journal of Radiation Oncology Biology, Physics, 2011, Vol.81(1), pp.167-174
Main Author: Li, Jing
Other Authors: Dabaja, Bouthaina , Reed, Valerie , Allen, Pamela K , Cai, Haihong , Amin, Mayankkumar V , Garcia, John A , Cox, James D
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0360-3016 ; E-ISSN: 1879-355X ; DOI: 10.1016/j.ijrobp.2010.05.007
Link: https://www.sciencedirect.com/science/article/pii/S0360301610006656
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recordid: elsevier_sdoi_10_1016_j_ijrobp_2010_05_007
title: Rationale for and Preliminary Results of Proton Beam Therapy for Mediastinal Lymphoma
format: Article
creator:
  • Li, Jing
  • Dabaja, Bouthaina
  • Reed, Valerie
  • Allen, Pamela K
  • Cai, Haihong
  • Amin, Mayankkumar V
  • Garcia, John A
  • Cox, James D
subjects:
  • Lymphatic Irradiation
  • Radiotherapy
  • Conformal
  • Dosimetry
  • Normal Tissue Toxicity
  • Medicine
ispartof: International Journal of Radiation Oncology, Biology, Physics, 2011, Vol.81(1), pp.167-174
description: To evaluate the potential of three-dimensional proton beam therapy (3D-PBT) for reducing doses to normal structures in patients with mediastinal lymphomas compared with conventional photon radiation therapy (RT). We treated 10 consecutive patients with mediastinal masses from lymphomas with 3D-PBT between July 2007 and February 2009 to 30.6–50.4 cobalt-Gray equivalents (CGE). Of those patients, 7 had primary refractory or recurrent disease, and 8 had Hodgkin lymphoma. Dosimetric endpoints were compared with those from conventional RT plans. PBT delivered lower mean doses to the lung (6.2 vs. 9.5 Gy), esophagus (9.5 vs. 22.3 Gy), and heart (8.8 vs. 17.7 Gy) but not the breasts (5.9 vs. 6.1 Gy) than did conventional RT. Percentages of lung, esophagus, heart, and coronary artery (particularly the left anterior descending artery) volumes receiving radiation were consistently lower in the 3D-PBT plans over a wide range of radiation doses. Of the 7 patients who had residual disease on positron emission tomography before PBT, 6 (86%) showed a complete metabolic response. In patients with mediastinal lymphomas, 3D-PBT produced significantly lower doses to the lung, esophagus, heart, and coronary arteries than did the current conventional RT. These lower doses would be expected to reduce the risk of late toxicities in these major organs.
language: eng
source:
identifier: ISSN: 0360-3016 ; E-ISSN: 1879-355X ; DOI: 10.1016/j.ijrobp.2010.05.007
fulltext: fulltext
issn:
  • 0360-3016
  • 03603016
  • 1879-355X
  • 1879355X
url: Link


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titleRationale for and Preliminary Results of Proton Beam Therapy for Mediastinal Lymphoma
creatorLi, Jing ; Dabaja, Bouthaina ; Reed, Valerie ; Allen, Pamela K ; Cai, Haihong ; Amin, Mayankkumar V ; Garcia, John A ; Cox, James D
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subjectLymphatic Irradiation ; Radiotherapy ; Conformal ; Dosimetry ; Normal Tissue Toxicity ; Medicine
descriptionTo evaluate the potential of three-dimensional proton beam therapy (3D-PBT) for reducing doses to normal structures in patients with mediastinal lymphomas compared with conventional photon radiation therapy (RT). We treated 10 consecutive patients with mediastinal masses from lymphomas with 3D-PBT between July 2007 and February 2009 to 30.6–50.4 cobalt-Gray equivalents (CGE). Of those patients, 7 had primary refractory or recurrent disease, and 8 had Hodgkin lymphoma. Dosimetric endpoints were compared with those from conventional RT plans. PBT delivered lower mean doses to the lung (6.2 vs. 9.5 Gy), esophagus (9.5 vs. 22.3 Gy), and heart (8.8 vs. 17.7 Gy) but not the breasts (5.9 vs. 6.1 Gy) than did conventional RT. Percentages of lung, esophagus, heart, and coronary artery (particularly the left anterior descending artery) volumes receiving radiation were consistently lower in the 3D-PBT plans over a wide range of radiation doses. Of the 7 patients who had residual disease on positron emission tomography before PBT, 6 (86%) showed a complete metabolic response. In patients with mediastinal lymphomas, 3D-PBT produced significantly lower doses to the lung, esophagus, heart, and coronary arteries than did the current conventional RT. These lower doses would be expected to reduce the risk of late toxicities in these major organs.
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