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Toward understanding the evolution of plaque rupture: Correlating vascular pathology with clinical outcomes

Unlike the postmortem, angioscopy can be repeated over months and can be performed in symptomatic living man. [...]angioscopy first allowed us to discover that patients with unstable angina have a disrupted intimal surface (3,4). The lesions that are most prone to postprocedure cardiac events most c... Full description

Journal Title: Journal of the American College of Cardiology 05 November 2003, Vol.42(9), pp.1566-1568
Main Author: Forrester, James S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2003.08.010
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recordid: elsevier_sdoi_10_1016_j_jacc_2003_08_010
title: Toward understanding the evolution of plaque rupture: Correlating vascular pathology with clinical outcomes
format: Article
creator:
  • Forrester, James S
subjects:
  • Medicine
ispartof: Journal of the American College of Cardiology, 05 November 2003, Vol.42(9), pp.1566-1568
description: Unlike the postmortem, angioscopy can be repeated over months and can be performed in symptomatic living man. [...]angioscopy first allowed us to discover that patients with unstable angina have a disrupted intimal surface (3,4). The lesions that are most prone to postprocedure cardiac events most commonly have a thin fibrous cap and a large lipid core (yellow plaques). Because these types of plaques are also most prone to spontaneous rupture, they presumably have a greater propensity to rupture and become thrombogenic during angioplasty (15,16). (18) found that, although the frequency of thrombus persistence is less than that observed after thrombolysis, the percentage remains strikingly high, 64%, at one month. [...]even with restoration of apparently normal flow, there remains a potent stimulus to rethrombosis, providing a biologic rationale for ongoing antiplatelet therapy.
language: eng
source:
identifier: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2003.08.010
fulltext: fulltext
issn:
  • 0735-1097
  • 07351097
  • 1558-3597
  • 15583597
url: Link


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descriptionUnlike the postmortem, angioscopy can be repeated over months and can be performed in symptomatic living man. [...]angioscopy first allowed us to discover that patients with unstable angina have a disrupted intimal surface (3,4). The lesions that are most prone to postprocedure cardiac events most commonly have a thin fibrous cap and a large lipid core (yellow plaques). Because these types of plaques are also most prone to spontaneous rupture, they presumably have a greater propensity to rupture and become thrombogenic during angioplasty (15,16). (18) found that, although the frequency of thrombus persistence is less than that observed after thrombolysis, the percentage remains strikingly high, 64%, at one month. [...]even with restoration of apparently normal flow, there remains a potent stimulus to rethrombosis, providing a biologic rationale for ongoing antiplatelet therapy.
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