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Lowering the Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated With the Beneficial Impact of Pioglitazone on Progression of Coronary Atherosclerosis in Diabetic Patients

The purpose of this study was to determine the factors associated with the favorable effect of pioglitazone on atheroma progression. Diabetes mellitus is associated with accelerated coronary atheroma progression. Pioglitazone slowed progression compared with glimepiride in this population. In all, 3... Full description

Journal Title: Journal of the American College of Cardiology 11 January 2011, Vol.57(2), pp.153-159
Main Author: Nicholls, Stephen J
Other Authors: Tuzcu, E. Murat , Wolski, Kathy , Bayturan, Ozgur , Lavoie, Andrea , Uno, Kiyoko , Kupfer, Stuart , Perez, Alfonso , Nesto, Richard , Nissen, Steven E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2010.06.055
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recordid: elsevier_sdoi_10_1016_j_jacc_2010_06_055
title: Lowering the Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated With the Beneficial Impact of Pioglitazone on Progression of Coronary Atherosclerosis in Diabetic Patients
format: Article
creator:
  • Nicholls, Stephen J
  • Tuzcu, E. Murat
  • Wolski, Kathy
  • Bayturan, Ozgur
  • Lavoie, Andrea
  • Uno, Kiyoko
  • Kupfer, Stuart
  • Perez, Alfonso
  • Nesto, Richard
  • Nissen, Steven E
subjects:
  • Atherosclerosis
  • Diabetes
  • Intravascular Ultrasonography
  • Medicine
ispartof: Journal of the American College of Cardiology, 11 January 2011, Vol.57(2), pp.153-159
description: The purpose of this study was to determine the factors associated with the favorable effect of pioglitazone on atheroma progression. Diabetes mellitus is associated with accelerated coronary atheroma progression. Pioglitazone slowed progression compared with glimepiride in this population. In all, 360 diabetic patients with coronary artery disease were treated with pioglitazone or glimepiride for 18 months in the PERISCOPE (Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation) study. Coronary atheroma progression was evaluated by serial intravascular ultrasound. The relationship between changes in biochemical parameters, percent atheroma volume, and total atheroma volume was investigated. Pioglitazone-treated patients demonstrated greater increases in high-density lipoprotein cholesterol (HDL-C) and reductions in glycated hemoglobin, triglycerides, and C-reactive protein....
language: eng
source:
identifier: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2010.06.055
fulltext: fulltext
issn:
  • 0735-1097
  • 07351097
  • 1558-3597
  • 15583597
url: Link


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titleLowering the Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated With the Beneficial Impact of Pioglitazone on Progression of Coronary Atherosclerosis in Diabetic Patients
creatorNicholls, Stephen J ; Tuzcu, E. Murat ; Wolski, Kathy ; Bayturan, Ozgur ; Lavoie, Andrea ; Uno, Kiyoko ; Kupfer, Stuart ; Perez, Alfonso ; Nesto, Richard ; Nissen, Steven E
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subjectAtherosclerosis ; Diabetes ; Intravascular Ultrasonography ; Medicine
descriptionThe purpose of this study was to determine the factors associated with the favorable effect of pioglitazone on atheroma progression. Diabetes mellitus is associated with accelerated coronary atheroma progression. Pioglitazone slowed progression compared with glimepiride in this population. In all, 360 diabetic patients with coronary artery disease were treated with pioglitazone or glimepiride for 18 months in the PERISCOPE (Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation) study. Coronary atheroma progression was evaluated by serial intravascular ultrasound. The relationship between changes in biochemical parameters, percent atheroma volume, and total atheroma volume was investigated. Pioglitazone-treated patients demonstrated greater increases in high-density lipoprotein cholesterol (HDL-C) and reductions in glycated hemoglobin, triglycerides, and C-reactive protein....
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