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Impact of Metabolic Syndrome on Progression of Aortic Stenosis

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2012.03.052 Byline: Romain Capoulade ([cor]), Marie-Annick Clavel ([cor]), Jean G. Dumesnil ([cor]), Kwan L. Chan (a ), Koon K. Teo (a ), James W. Tam (As.), Nancy Cote ([cor]), Patrick Mathieu ([cor]), J... Full description

Journal Title: Journal of the American College of Cardiology 17 July 2012, Vol.60(3), pp.216-223
Main Author: Capoulade, Romain
Other Authors: Clavel, Marie-Annick , Dumesnil, Jean G , Chan, Kwan L , Teo, Koon K , Tam, James W , Côté, Nancy , Mathieu, Patrick , Després, Jean-Pierre , Pibarot, Philippe
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2012.03.052
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recordid: elsevier_sdoi_10_1016_j_jacc_2012_03_052
title: Impact of Metabolic Syndrome on Progression of Aortic Stenosis
format: Article
creator:
  • Capoulade, Romain
  • Clavel, Marie-Annick
  • Dumesnil, Jean G
  • Chan, Kwan L
  • Teo, Koon K
  • Tam, James W
  • Côté, Nancy
  • Mathieu, Patrick
  • Després, Jean-Pierre
  • Pibarot, Philippe
subjects:
  • Aortic Stenosis
  • Doppler Echocardiography
  • Metabolic Syndrome
  • Obesity
  • Statins
  • Medicine
ispartof: Journal of the American College of Cardiology, 17 July 2012, Vol.60(3), pp.216-223
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2012.03.052 Byline: Romain Capoulade ([cor]), Marie-Annick Clavel ([cor]), Jean G. Dumesnil ([cor]), Kwan L. Chan (a ), Koon K. Teo (a ), James W. Tam (As.), Nancy Cote ([cor]), Patrick Mathieu ([cor]), Jean-Pierre Despres ([cor]), Philippe Pibarot ([cor]) Keywords: aortic stenosis; Doppler echocardiography; metabolic syndrome; obesity; statins Abbreviations: AS, aortic stenosis; AVA, aortic valve area; AVR, aortic valve replacement; DVI, Doppler velocity index; HOMA, homeostatic assessment model; LDL, low-density lipoprotein; LV, left ventricle; MetS, metabolic syndrome; NS, not significant; V.sub.peak, peak aortic jet velocity Abstract: The aims of this study were to examine prospectively the relationship between metabolic syndrome (MetS) and aortic stenosis (AS) progression and to evaluate the effect of age and statin therapy on AS progression in patients with or without MetS. Author Affiliation: ([cor]) Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec/Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (a ) Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (a ) Department of Medicine, McMaster University, Hamilton, Ontario, Canada (As.) Department of Cardiology, St. Boniface General Hospital, Winnipeg, Manitoba, Canada Article History: Received 24 January 2012; Revised 1 March 2012; Accepted 5 March 2012 Article Note: (footnote) The ASTRONOMER trial is funded by AstraZeneca and the Canadian Institutes of Health Research (CIHR), Ottawa, Canada. This substudy was also funded in part by a CIHR grant no. MOP-114997. Dr. Pibarot holds the Canada Research Chair in Valvular Heart Diseases supported by CIHR. Dr. Clavel holds a Vanier Canada Graduate Scholarship, Canadian Institutes of Health Research, Ottawa, Ontario, Canada. Dr. Mathieu is a research scholar from the Fonds de Recherches en Sante du Quebec, Montreal, Canada. Dr. Despres is the scientific director of the International Chair on Cardiometabolic Risk at Universite Laval, which is supported by an unrestricted grant from Sanofi-Aventis awarded to Universite Laval; has served as a speaker for Abbott Laboratories, AstraZeneca, Solvay Pharma, GlaxoSmithKline, and Pfizer Canada, Inc.; has received research funding from Eli Lilly Canada; and has served on the advisory boards of Novartis, Theratechnologie
language: eng
source:
identifier: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2012.03.052
fulltext: fulltext
issn:
  • 0735-1097
  • 07351097
  • 1558-3597
  • 15583597
url: Link


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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2012.03.052 Byline: Romain Capoulade ([cor]), Marie-Annick Clavel ([cor]), Jean G. Dumesnil ([cor]), Kwan L. Chan (a ), Koon K. Teo (a ), James W. Tam (As.), Nancy Cote ([cor]), Patrick Mathieu ([cor]), Jean-Pierre Despres ([cor]), Philippe Pibarot ([cor]) Keywords: aortic stenosis; Doppler echocardiography; metabolic syndrome; obesity; statins Abbreviations: AS, aortic stenosis; AVA, aortic valve area; AVR, aortic valve replacement; DVI, Doppler velocity index; HOMA, homeostatic assessment model; LDL, low-density lipoprotein; LV, left ventricle; MetS, metabolic syndrome; NS, not significant; V.sub.peak, peak aortic jet velocity Abstract: The aims of this study were to examine prospectively the relationship between metabolic syndrome (MetS) and aortic stenosis (AS) progression and to evaluate the effect of age and statin therapy on AS progression in patients with or without MetS. Author Affiliation: ([cor]) Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec/Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (a ) Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (a ) Department of Medicine, McMaster University, Hamilton, Ontario, Canada (As.) Department of Cardiology, St. Boniface General Hospital, Winnipeg, Manitoba, Canada Article History: Received 24 January 2012; Revised 1 March 2012; Accepted 5 March 2012 Article Note: (footnote) The ASTRONOMER trial is funded by AstraZeneca and the Canadian Institutes of Health Research (CIHR), Ottawa, Canada. This substudy was also funded in part by a CIHR grant no. MOP-114997. Dr. Pibarot holds the Canada Research Chair in Valvular Heart Diseases supported by CIHR. Dr. Clavel holds a Vanier Canada Graduate Scholarship, Canadian Institutes of Health Research, Ottawa, Ontario, Canada. Dr. Mathieu is a research scholar from the Fonds de Recherches en Sante du Quebec, Montreal, Canada. Dr. Despres is the scientific director of the International Chair on Cardiometabolic Risk at Universite Laval, which is supported by an unrestricted grant from Sanofi-Aventis awarded to Universite Laval; has served as a speaker for Abbott Laboratories, AstraZeneca, Solvay Pharma, GlaxoSmithKline, and Pfizer Canada, Inc.; has received research funding from Eli Lilly Canada; and has served on the advisory boards of Novartis, Theratechnologies, Torrent Pharmaceuticals Ltd., and Sanofi-Aventis. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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