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Lipoprotein(a) Levels in Familial Hypercholesterolemia

The aim of this study was to determine the relationship between lipoprotein(a) [Lp(a)] and cardiovascular disease (CVD) in a large cohort of patients with heterozygous familial hypercholesterolemia (FH). Lp(a) is considered a cardiovascular risk factor. Nevertheless, the role of Lp(a) as a predictor... Full description

Journal Title: Journal of the American College of Cardiology 20 May 2014, Vol.63(19), pp.1982-1989
Main Author: Alonso, Rodrigo
Other Authors: Andres, Eduardo , Mata, Nelva , Fuentes-Jiménez, Francisco , Badimón, Lina , López-Miranda, José , Padró, Teresa , Muñiz, Ovidio , Díaz-Díaz, Jose Luis , Mauri, Marta , Ordovás, Jose María , Mata, Pedro
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2014.01.063
Link: https://www.sciencedirect.com/science/article/pii/S0735109714012959
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recordid: elsevier_sdoi_10_1016_j_jacc_2014_01_063
title: Lipoprotein(a) Levels in Familial Hypercholesterolemia
format: Article
creator:
  • Alonso, Rodrigo
  • Andres, Eduardo
  • Mata, Nelva
  • Fuentes-Jiménez, Francisco
  • Badimón, Lina
  • López-Miranda, José
  • Padró, Teresa
  • Muñiz, Ovidio
  • Díaz-Díaz, Jose Luis
  • Mauri, Marta
  • Ordovás, Jose María
  • Mata, Pedro
subjects:
  • Cardiovascular Disease
  • Familial Hypercholesterolemia
  • Ldl receptor Mutations
  • Lipoprotein(a)
  • Medicine
ispartof: Journal of the American College of Cardiology, 20 May 2014, Vol.63(19), pp.1982-1989
description: The aim of this study was to determine the relationship between lipoprotein(a) [Lp(a)] and cardiovascular disease (CVD) in a large cohort of patients with heterozygous familial hypercholesterolemia (FH). Lp(a) is considered a cardiovascular risk factor. Nevertheless, the role of Lp(a) as a predictor of CVD in patients with FH has been a controversial issue. A cross-sectional analysis of 1,960 patients with FH and 957 non-FH relatives recruited for SAFEHEART (Spanish Familial Hypercholesterolemia Cohort Study), a long-term observational cohort study of a molecularly well-defined FH study group, was performed. Lp(a) concentrations were measured in plasma using an immunoturbidimetric method. Patients with FH, especially those with CVD, had higher Lp(a) plasma levels compared with their unaffected relatives (p < 0.001). A significant difference in Lp(a) levels was observed when the most frequent null and defective mutations in mutations were analyzed (p < 0.0016). On multivariate analysis, Lp(a) was an independent predictor of cardiovascular disease. Patients carrying null mutations and Lp(a) levels >50 mg/dl showed the highest cardiovascular risk compared with patients carrying the same mutations and Lp(a) levels 50 mg/dl and carrying a receptor-negative mutation in the gene compared with other less severe mutations.
language: eng
source:
identifier: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2014.01.063
fulltext: fulltext
issn:
  • 0735-1097
  • 07351097
  • 1558-3597
  • 15583597
url: Link


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titleLipoprotein(a) Levels in Familial Hypercholesterolemia
creatorAlonso, Rodrigo ; Andres, Eduardo ; Mata, Nelva ; Fuentes-Jiménez, Francisco ; Badimón, Lina ; López-Miranda, José ; Padró, Teresa ; Muñiz, Ovidio ; Díaz-Díaz, Jose Luis ; Mauri, Marta ; Ordovás, Jose María ; Mata, Pedro
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subjectCardiovascular Disease ; Familial Hypercholesterolemia ; Ldl receptor Mutations ; Lipoprotein(a) ; Medicine
descriptionThe aim of this study was to determine the relationship between lipoprotein(a) [Lp(a)] and cardiovascular disease (CVD) in a large cohort of patients with heterozygous familial hypercholesterolemia (FH). Lp(a) is considered a cardiovascular risk factor. Nevertheless, the role of Lp(a) as a predictor of CVD in patients with FH has been a controversial issue. A cross-sectional analysis of 1,960 patients with FH and 957 non-FH relatives recruited for SAFEHEART (Spanish Familial Hypercholesterolemia Cohort Study), a long-term observational cohort study of a molecularly well-defined FH study group, was performed. Lp(a) concentrations were measured in plasma using an immunoturbidimetric method. Patients with FH, especially those with CVD, had higher Lp(a) plasma levels compared with their unaffected relatives (p < 0.001). A significant difference in Lp(a) levels was observed when the most frequent null and defective mutations in mutations were analyzed (p < 0.0016). On multivariate analysis, Lp(a) was an independent predictor of cardiovascular disease. Patients carrying null mutations and Lp(a) levels >50 mg/dl showed the highest cardiovascular risk compared with patients carrying the same mutations and Lp(a) levels <50 mg/dl. Lp(a) is an independent predictor of CVD in men and women with FH. The risk of CVD is higher in those patients with an Lp(a) level >50 mg/dl and carrying a receptor-negative mutation in the gene compared with other less severe mutations.
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