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52 Genetic Loci Influencing Myocardial Mass

Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocard... Full description

Journal Title: Journal of the American College of Cardiology 27 September 2016, Vol.68(13), pp.1435-1448
Main Author: van Der Harst, Pim
Other Authors: van Setten, Jessica , Verweij, Niek , Vogler, Georg , Franke, Lude , Maurano, Matthew T , Wang, Xinchen , Mateo Leach, Irene , Eijgelsheim, Mark , Sotoodehnia, Nona , Hayward, Caroline , Sorice, Rossella , Meirelles, Osorio , Lyytikäinen, Leo-Pekka , Polašek, Ozren , Tanaka, Toshiko , Arking, Dan E , Ulivi, Sheila
Format: Electronic Article Electronic Article
Language: English
Subjects:
Qrs
ID: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2016.07.729
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recordid: elsevier_sdoi_10_1016_j_jacc_2016_07_729
title: 52 Genetic Loci Influencing Myocardial Mass
format: Article
creator:
  • van Der Harst, Pim
  • van Setten, Jessica
  • Verweij, Niek
  • Vogler, Georg
  • Franke, Lude
  • Maurano, Matthew T
  • Wang, Xinchen
  • Mateo Leach, Irene
  • Eijgelsheim, Mark
  • Sotoodehnia, Nona
  • Hayward, Caroline
  • Sorice, Rossella
  • Meirelles, Osorio
  • Lyytikäinen, Leo-Pekka
  • Polašek, Ozren
  • Tanaka, Toshiko
  • Arking, Dan E
  • Ulivi, Sheila
subjects:
  • Electrocardiogram
  • Genetic Association Study
  • Heart Failure
  • Left Ventricular Hypertrophy
  • Qrs
  • Medicine
ispartof: Journal of the American College of Cardiology, 27 September 2016, Vol.68(13), pp.1435-1448
description: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment. We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p < 1 × 10 . These loci are enriched in regions of open chromatin, histone modifications, and transcription factor binding, suggesting...
language: eng
source:
identifier: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2016.07.729
fulltext: fulltext
issn:
  • 0735-1097
  • 07351097
  • 1558-3597
  • 15583597
url: Link


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title52 Genetic Loci Influencing Myocardial Mass
creatorvan Der Harst, Pim ; van Setten, Jessica ; Verweij, Niek ; Vogler, Georg ; Franke, Lude ; Maurano, Matthew T ; Wang, Xinchen ; Mateo Leach, Irene ; Eijgelsheim, Mark ; Sotoodehnia, Nona ; Hayward, Caroline ; Sorice, Rossella ; Meirelles, Osorio ; Lyytikäinen, Leo-Pekka ; Polašek, Ozren ; Tanaka, Toshiko ; Arking, Dan E ; Ulivi, Sheila
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subjectElectrocardiogram ; Genetic Association Study ; Heart Failure ; Left Ventricular Hypertrophy ; Qrs ; Medicine
descriptionMyocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment. We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p < 1 × 10 . These loci are enriched in regions of open chromatin, histone modifications, and transcription factor binding, suggesting...
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