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Hypertensive Disorders of Pregnancy and 10-Year Cardiovascular Risk Prediction

Hypertensive disorders of pregnancy (HDP) affect 10% to 15% of women and are associated with a 2-fold increased risk of cardiovascular disease (CVD). This study sought to determine whether inclusion of HDP in an established CVD risk score improves prediction of CVD events in women. The analysis comp... Full description

Journal Title: Journal of the American College of Cardiology 11 September 2018, Vol.72(11), pp.1252-1263
Main Author: Stuart, Jennifer J
Other Authors: Tanz, Lauren J , Cook, Nancy R , Spiegelman, Donna , Missmer, Stacey A , Rimm, Eric B , Rexrode, Kathryn M , Mukamal, Kenneth J , Rich-Edwards, Janet W
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2018.05.077
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recordid: elsevier_sdoi_10_1016_j_jacc_2018_05_077
title: Hypertensive Disorders of Pregnancy and 10-Year Cardiovascular Risk Prediction
format: Article
creator:
  • Stuart, Jennifer J
  • Tanz, Lauren J
  • Cook, Nancy R
  • Spiegelman, Donna
  • Missmer, Stacey A
  • Rimm, Eric B
  • Rexrode, Kathryn M
  • Mukamal, Kenneth J
  • Rich-Edwards, Janet W
subjects:
  • Cardiovascular Disease
  • Cardiovascular Disease Risk Factors
  • Pre-Eclampsia
  • Pregnancy
  • Medicine
ispartof: Journal of the American College of Cardiology, 11 September 2018, Vol.72(11), pp.1252-1263
description: Hypertensive disorders of pregnancy (HDP) affect 10% to 15% of women and are associated with a 2-fold increased risk of cardiovascular disease (CVD). This study sought to determine whether inclusion of HDP in an established CVD risk score improves prediction of CVD events in women. The analysis comprised 106,230 ≤10-year observations contributed by 67,406 women, age ≥40 years, free of prior CVD, with data available on model covariates in the Nurses’ Health Study II. Participants were followed up for confirmed myocardial infarction, fatal coronary heart disease, or stroke from 1989 to 2013. We fit an established CVD risk prediction model (Model A: age, total cholesterol and high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive medication use, current smoking, diabetes mellitus) and compared it to the same model plus HDP and parity (Model B); Cox proportional hazards models were used to obtain predicted probabilities...
language: eng
source:
identifier: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/j.jacc.2018.05.077
fulltext: fulltext
issn:
  • 0735-1097
  • 07351097
  • 1558-3597
  • 15583597
url: Link


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creatorStuart, Jennifer J ; Tanz, Lauren J ; Cook, Nancy R ; Spiegelman, Donna ; Missmer, Stacey A ; Rimm, Eric B ; Rexrode, Kathryn M ; Mukamal, Kenneth J ; Rich-Edwards, Janet W
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subjectCardiovascular Disease ; Cardiovascular Disease Risk Factors ; Pre-Eclampsia ; Pregnancy ; Medicine
descriptionHypertensive disorders of pregnancy (HDP) affect 10% to 15% of women and are associated with a 2-fold increased risk of cardiovascular disease (CVD). This study sought to determine whether inclusion of HDP in an established CVD risk score improves prediction of CVD events in women. The analysis comprised 106,230 ≤10-year observations contributed by 67,406 women, age ≥40 years, free of prior CVD, with data available on model covariates in the Nurses’ Health Study II. Participants were followed up for confirmed myocardial infarction, fatal coronary heart disease, or stroke from 1989 to 2013. We fit an established CVD risk prediction model (Model A: age, total cholesterol and high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive medication use, current smoking, diabetes mellitus) and compared it to the same model plus HDP and parity (Model B); Cox proportional hazards models were used to obtain predicted probabilities...
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titleHypertensive Disorders of Pregnancy and 10-Year Cardiovascular Risk Prediction
description

Hypertensive disorders of pregnancy (HDP) affect 10% to 15% of women and are associated with a 2-fold increased risk of cardiovascular disease (CVD).

This study sought to determine whether inclusion of HDP in an established CVD risk score improves prediction of CVD events in women.

The analysis comprised 106,230 ≤10-year observations contributed by 67,406 women, age ≥40 years, free of prior CVD, with data available on model covariates in the Nurses’ Health Study II. Participants were followed up for confirmed myocardial infarction, fatal coronary heart disease, or stroke from 1989 to 2013. We fit an established CVD risk prediction model (Model A: age, total cholesterol and high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive medication use, current smoking, diabetes mellitus) and compared it to the same model plus HDP and parity (Model B); Cox proportional hazards models were used to obtain predicted probabilities...

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Hypertensive disorders of pregnancy (HDP) affect 10% to 15% of women and are associated with a 2-fold increased risk of cardiovascular disease (CVD).

This study sought to determine whether inclusion of HDP in an established CVD risk score improves prediction of CVD events in women.

The analysis comprised 106,230 ≤10-year observations contributed by 67,406 women, age ≥40 years, free of prior CVD, with data available on model covariates in the Nurses’ Health Study II. Participants were followed up for confirmed myocardial infarction, fatal coronary heart disease, or stroke from 1989 to 2013. We fit an established CVD risk prediction model (Model A: age, total cholesterol and high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive medication use, current smoking, diabetes mellitus) and compared it to the same model plus HDP and parity (Model B); Cox proportional hazards models were used to obtain predicted probabilities...

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