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Thymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis

Although invariant natural killer T (iNKT) cells have been shown to play a critical role in the pathogenesis of asthma, the role of iNKT cells in atopic dermatitis (AD) has not been well evaluated. We investigated whether iNKT cells in patients with AD increased and whether iNKT cells were activated... Full description

Journal Title: The Journal of Allergy and Clinical Immunology 2010, Vol.126(2), pp.290-299.e4
Main Author: Wu, Wen Hao
Other Authors: Park, Chang Ook , Oh, Sang Ho , Kim, Hee Jung , Kwon, Yeon Sook , Bae, Byung Gi , Noh, Ji Yeon , Lee, Kwang Hoon
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2010.05.024
Link: https://www.sciencedirect.com/science/article/pii/S0091674910008493
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recordid: elsevier_sdoi_10_1016_j_jaci_2010_05_024
title: Thymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis
format: Article
creator:
  • Wu, Wen Hao
  • Park, Chang Ook
  • Oh, Sang Ho
  • Kim, Hee Jung
  • Kwon, Yeon Sook
  • Bae, Byung Gi
  • Noh, Ji Yeon
  • Lee, Kwang Hoon
subjects:
  • Atopic Dermatitis
  • Invariant Natural Killer T Cells
  • Nkt Cells
  • Thymic Stromal Lymphopoietin
  • Dendritic Cells
  • Medicine
ispartof: The Journal of Allergy and Clinical Immunology, 2010, Vol.126(2), pp.290-299.e4
description: Although invariant natural killer T (iNKT) cells have been shown to play a critical role in the pathogenesis of asthma, the role of iNKT cells in atopic dermatitis (AD) has not been well evaluated. We investigated whether iNKT cells in patients with AD increased and whether iNKT cells were activated by thymic stromal lymphopoietin (TSLP), which is highly expressed in keratinocytes of AD. We assessed the population of iNKT cells in PBMCs of patients with AD and healthy controls (HCs) using flow cytometry. Immunohistochemistry was used to evaluate iNKT cells and TSLP expression in AD and HC skin. We also evaluated whether iNKT cells expressed the TSLP receptor, the effects of TSLP on iNKT cells, and iNKT cell–dendritic cell interactions in a TSLP-rich environment. There were more iNKT cells among PBMCs of patients with moderate to severe AD than mild AD (  < .05) and HC (  
language: eng
source:
identifier: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2010.05.024
fulltext: fulltext
issn:
  • 0091-6749
  • 00916749
  • 1097-6825
  • 10976825
url: Link


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titleThymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis
creatorWu, Wen Hao ; Park, Chang Ook ; Oh, Sang Ho ; Kim, Hee Jung ; Kwon, Yeon Sook ; Bae, Byung Gi ; Noh, Ji Yeon ; Lee, Kwang Hoon
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subjectAtopic Dermatitis ; Invariant Natural Killer T Cells ; Nkt Cells ; Thymic Stromal Lymphopoietin ; Dendritic Cells ; Medicine
descriptionAlthough invariant natural killer T (iNKT) cells have been shown to play a critical role in the pathogenesis of asthma, the role of iNKT cells in atopic dermatitis (AD) has not been well evaluated. We investigated whether iNKT cells in patients with AD increased and whether iNKT cells were activated by thymic stromal lymphopoietin (TSLP), which is highly expressed in keratinocytes of AD. We assessed the population of iNKT cells in PBMCs of patients with AD and healthy controls (HCs) using flow cytometry. Immunohistochemistry was used to evaluate iNKT cells and TSLP expression in AD and HC skin. We also evaluated whether iNKT cells expressed the TSLP receptor, the effects of TSLP on iNKT cells, and iNKT cell–dendritic cell interactions in a TSLP-rich environment. There were more iNKT cells among PBMCs of patients with moderate to severe AD than mild AD (  < .05) and HC (  < .001)....
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