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A trial of clarithromycin for the treatment of suboptimally controlled asthma

PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma. To test the hypothesis that clarithromycin would improve asthma control in individuals with mild-to-moderate persistent asthma that was not well controlled despi... Full description

Journal Title: The Journal of Allergy and Clinical Immunology 2010, Vol.126(4), pp.747-753
Main Author: Sutherland, E. Rand
Other Authors: King, Tonya S , Icitovic, Nikolina , Ameredes, Bill T , Bleecker, Eugene , Boushey, Homer A , Calhoun, William J , Castro, Mario , Cherniack, Reuben M , Chinchilli, Vernon M , Craig, Timothy J , Denlinger, Loren , Dimango, Emily A , Fahy, John V , Israel, Elliot , Jarjour, Nizar , Kraft, Monica , Lazarus, Stephen C , Lemanske, Robert F , Peters, Stephen P
Format: Electronic Article Electronic Article
Language: English
Subjects:
Acq
ICS
Pcr
ID: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2010.07.024
Link: http://dx.doi.org/10.1016/j.jaci.2010.07.024
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recordid: elsevier_sdoi_10_1016_j_jaci_2010_07_024
title: A trial of clarithromycin for the treatment of suboptimally controlled asthma
format: Article
creator:
  • Sutherland, E. Rand
  • King, Tonya S
  • Icitovic, Nikolina
  • Ameredes, Bill T
  • Bleecker, Eugene
  • Boushey, Homer A
  • Calhoun, William J
  • Castro, Mario
  • Cherniack, Reuben M
  • Chinchilli, Vernon M
  • Craig, Timothy J
  • Denlinger, Loren
  • Dimango, Emily A
  • Fahy, John V
  • Israel, Elliot
  • Jarjour, Nizar
  • Kraft, Monica
  • Lazarus, Stephen C
  • Lemanske, Robert F
  • Peters, Stephen P
subjects:
  • Asthma
  • Infection
  • Antibiotic
  • Asthma
  • Infection
  • Antibiotic
  • Acq
  • Acrn
  • ICS
  • Nhlbi
  • Pcr
  • Medicine
ispartof: The Journal of Allergy and Clinical Immunology, 2010, Vol.126(4), pp.747-753
description: PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma. To test the hypothesis that clarithromycin would improve asthma control in individuals with mild-to-moderate persistent asthma that was not well controlled despite treatment with low-dose inhaled corticosteroids. Adults with an Asthma Control Questionnaire score ≥1.5 after a 4-week period of treatment with fluticasone propionate were entered into a PCR-stratified randomized, controlled trial to evaluate the effect of 16 weeks of either clarithromycin or placebo, added to fluticasone, on asthma control in individuals with or without lower airway PCR evidence of M pneumoniae or C pneumoniae. A total of 92 participants were randomized. Twelve (13%) subjects demonstrated PCR evidence of M pneumoniae or C pneumoniae in endobronchial biopsies; 80 were PCR-negative...
language: eng
source:
identifier: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2010.07.024
fulltext: fulltext
issn:
  • 0091-6749
  • 00916749
  • 1097-6825
  • 10976825
url: Link


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creatorSutherland, E. Rand ; King, Tonya S ; Icitovic, Nikolina ; Ameredes, Bill T ; Bleecker, Eugene ; Boushey, Homer A ; Calhoun, William J ; Castro, Mario ; Cherniack, Reuben M ; Chinchilli, Vernon M ; Craig, Timothy J ; Denlinger, Loren ; Dimango, Emily A ; Fahy, John V ; Israel, Elliot ; Jarjour, Nizar ; Kraft, Monica ; Lazarus, Stephen C ; Lemanske, Robert F ; Peters, Stephen P
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descriptionPCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma. To test the hypothesis that clarithromycin would improve asthma control in individuals with mild-to-moderate persistent asthma that was not well controlled despite treatment with low-dose inhaled corticosteroids. Adults with an Asthma Control Questionnaire score ≥1.5 after a 4-week period of treatment with fluticasone propionate were entered into a PCR-stratified randomized, controlled trial to evaluate the effect of 16 weeks of either clarithromycin or placebo, added to fluticasone, on asthma control in individuals with or without lower airway PCR evidence of M pneumoniae or C pneumoniae. A total of 92 participants were randomized. Twelve (13%) subjects demonstrated PCR evidence of M pneumoniae or C pneumoniae in endobronchial biopsies; 80 were PCR-negative...
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