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Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients

Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function. We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations. Genome-wide associ... Full description

Journal Title: The Journal of Allergy and Clinical Immunology August 2013, Vol.132(2), pp.313-320.e15
Main Author: Li, Xingnan
Other Authors: Hawkins, Gregory A , Ampleford, Elizabeth J , Moore, Wendy C , Li, Huashi , Hastie, Annette T , Howard, Timothy D , Boushey, Homer A , Busse, William W , Calhoun, William J , Castro, Mario , Erzurum, Serpil C , Israel, Elliot , Lemanske, Robert F , Szefler, Stanley J , Wasserman, Stephen I , Wenzel, Sally E , Peters, Stephen P , Meyers, Deborah A , Bleecker, Eugene R
Format: Electronic Article Electronic Article
Language: English
Subjects:
Th1
Th1
Ats
ID: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2013.01.051
Link: http://dx.doi.org/10.1016/j.jaci.2013.01.051
Zum Text:
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title: Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
format: Article
creator:
  • Li, Xingnan
  • Hawkins, Gregory A
  • Ampleford, Elizabeth J
  • Moore, Wendy C
  • Li, Huashi
  • Hastie, Annette T
  • Howard, Timothy D
  • Boushey, Homer A
  • Busse, William W
  • Calhoun, William J
  • Castro, Mario
  • Erzurum, Serpil C
  • Israel, Elliot
  • Lemanske, Robert F
  • Szefler, Stanley J
  • Wasserman, Stephen I
  • Wenzel, Sally E
  • Peters, Stephen P
  • Meyers, Deborah A
  • Bleecker, Eugene R
subjects:
  • Lung Function
  • Fev1
  • Asthma
  • Th1
  • Il12a
  • Il12rb1
  • Stat4
  • Irf2
  • Lung Function
  • Fev1
  • Asthma
  • Th1
  • Il12a
  • Il12rb1
  • Stat4
  • Irf2
  • Acrn
  • Ats
  • Basalt
  • Csga
ispartof: The Journal of Allergy and Clinical Immunology, August 2013, Vol.132(2), pp.313-320.e15
description: Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function. We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations. Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses. Seven of 28 previously identified lung function loci (HHIP, FAM13A, THSD4, GSTCD, NOTCH4-AGER, RARB, and ZNF323) identified in general populations were confirmed at single nucleotide polymorphism (SNP) levels (P  .05). Four of 32 loci (IL12A, IL12RB1, STAT4, and IRF2) associated with ppFEV1 (P  10−4) belong to the TH1 or IL-12 cytokine family pathway. By using a linear additive model,...
language: eng
source:
identifier: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2013.01.051
fulltext: fulltext
issn:
  • 0091-6749
  • 00916749
  • 1097-6825
  • 10976825
url: Link


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titleGenome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
creatorLi, Xingnan ; Hawkins, Gregory A ; Ampleford, Elizabeth J ; Moore, Wendy C ; Li, Huashi ; Hastie, Annette T ; Howard, Timothy D ; Boushey, Homer A ; Busse, William W ; Calhoun, William J ; Castro, Mario ; Erzurum, Serpil C ; Israel, Elliot ; Lemanske, Robert F ; Szefler, Stanley J ; Wasserman, Stephen I ; Wenzel, Sally E ; Peters, Stephen P ; Meyers, Deborah A ; Bleecker, Eugene R
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subjectLung Function ; Fev1 ; Asthma ; Th1 ; Il12a ; Il12rb1 ; Stat4 ; Irf2 ; Lung Function ; Fev1 ; Asthma ; Th1 ; Il12a ; Il12rb1 ; Stat4 ; Irf2 ; Acrn ; Ats ; Basalt ; Csga
descriptionRecent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function. We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations. Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses. Seven of 28 previously identified lung function loci (HHIP, FAM13A, THSD4, GSTCD, NOTCH4-AGER, RARB, and ZNF323) identified in general populations were confirmed at single nucleotide polymorphism (SNP) levels (P  .05). Four of 32 loci (IL12A, IL12RB1, STAT4, and IRF2) associated with ppFEV1 (P  10−4) belong to the TH1 or IL-12 cytokine family pathway. By using a linear additive model,...
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