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A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes

Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing. We eva... Full description

Journal Title: The Journal of Allergy and Clinical Immunology November 2014, Vol.134(5), pp.1153-1162
Main Author: Sharma, Sunita
Other Authors: Zhou, Xiaobo , Thibault, Derek M , Himes, Blanca E , Liu, Andy , Szefler, Stanley J , Strunk, Robert , Castro, Mario , Hansel, Nadia N , Diette, Gregory B , Vonakis, Becky M , Adkinson, N. Franklin , Avila, Lydiana , Soto-Quiros, Manuel , Barraza-Villareal, Albino , Lemanske, Robert F , Solway, Julian , Krishnan, Jerry , White, Steven R , Cheadle, Chris
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2014.04.011
Link: http://dx.doi.org/10.1016/j.jaci.2014.04.011
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recordid: elsevier_sdoi_10_1016_j_jaci_2014_04_011
title: A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes
format: Article
creator:
  • Sharma, Sunita
  • Zhou, Xiaobo
  • Thibault, Derek M
  • Himes, Blanca E
  • Liu, Andy
  • Szefler, Stanley J
  • Strunk, Robert
  • Castro, Mario
  • Hansel, Nadia N
  • Diette, Gregory B
  • Vonakis, Becky M
  • Adkinson, N. Franklin
  • Avila, Lydiana
  • Soto-Quiros, Manuel
  • Barraza-Villareal, Albino
  • Lemanske, Robert F
  • Solway, Julian
  • Krishnan, Jerry
  • White, Steven R
  • Cheadle, Chris
subjects:
  • Asthma
  • Cd4+ Lymphocytes
  • Regulatory Variants
  • Expression Quantitative Trait Locus
  • Haplotype
  • Integrative Genomics
  • Asthma
  • Cd4+ Lymphocytes
  • Regulatory Variants
  • Expression Quantitative Trait Locus
  • Haplotype
  • Integrative Genomics
  • Asthma Bridge
  • Camp
  • Chip
  • Eqtl
  • Esnp
  • F13a1
  • Fads1
  • Fads2
ispartof: The Journal of Allergy and Clinical Immunology, November 2014, Vol.134(5), pp.1153-1162
description: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing. We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a genome-wide eQTL survey of CD4+ lymphocytes for association with asthma. eSNPs were tested for association with asthma in 359 asthmatic patients and 846 control subjects from the Childhood Asthma Management Program, with verification by using family-based testing. Significant associations were tested for replication in 579 parent-child trios with asthma from Costa Rica. Further functional validation was performed by using formaldehyde-assisted isolation of regulatory elements (FAIRE) quantitative PCR and chromatin immunoprecipitation PCR in lung-derived epithelial...
language: eng
source:
identifier: ISSN: 0091-6749 ; E-ISSN: 1097-6825 ; DOI: 10.1016/j.jaci.2014.04.011
fulltext: fulltext
issn:
  • 0091-6749
  • 00916749
  • 1097-6825
  • 10976825
url: Link


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titleA genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes
creatorSharma, Sunita ; Zhou, Xiaobo ; Thibault, Derek M ; Himes, Blanca E ; Liu, Andy ; Szefler, Stanley J ; Strunk, Robert ; Castro, Mario ; Hansel, Nadia N ; Diette, Gregory B ; Vonakis, Becky M ; Adkinson, N. Franklin ; Avila, Lydiana ; Soto-Quiros, Manuel ; Barraza-Villareal, Albino ; Lemanske, Robert F ; Solway, Julian ; Krishnan, Jerry ; White, Steven R ; Cheadle, Chris
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descriptionGenome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing. We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a genome-wide eQTL survey of CD4+ lymphocytes for association with asthma. eSNPs were tested for association with asthma in 359 asthmatic patients and 846 control subjects from the Childhood Asthma Management Program, with verification by using family-based testing. Significant associations were tested for replication in 579 parent-child trios with asthma from Costa Rica. Further functional validation was performed by using formaldehyde-assisted isolation of regulatory elements (FAIRE) quantitative PCR and chromatin immunoprecipitation PCR in lung-derived epithelial...
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Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing.

We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a genome-wide eQTL survey of CD4+ lymphocytes for association with asthma.

eSNPs were tested for association with asthma in 359 asthmatic patients and 846 control subjects from the Childhood Asthma Management Program, with verification by using family-based testing. Significant associations were tested for replication in 579 parent-child trios with asthma from Costa Rica. Further functional validation was performed by using formaldehyde-assisted isolation of regulatory elements (FAIRE) quantitative PCR and chromatin immunoprecipitation PCR in lung-derived epithelial...

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abstract

Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing.

We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a genome-wide eQTL survey of CD4+ lymphocytes for association with asthma.

eSNPs were tested for association with asthma in 359 asthmatic patients and 846 control subjects from the Childhood Asthma Management Program, with verification by using family-based testing. Significant associations were tested for replication in 579 parent-child trios with asthma from Costa Rica. Further functional validation was performed by using formaldehyde-assisted isolation of regulatory elements (FAIRE) quantitative PCR and chromatin immunoprecipitation PCR in lung-derived epithelial...

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