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Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: Replications and implications for resolving inconsistent results

Genetic and environmental factors shape life-long vulnerability to depression, but most gene–environment interaction (G × E) research has focused on cross-sectional assessments rather than life-course phenotypes. This study tests the hypothesis that the G × E involving the length polymorphism in the... Full description

Journal Title: Journal of Affective Disorders December 2011, Vol.135(1-3), pp.56-65
Main Author: Uher, Rudolf
Other Authors: Caspi, Avshalom , Houts, Renate , Sugden, Karen , Williams, Benjamin , Poulton, Richie , Moffitt, Terrie E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0165-0327 ; E-ISSN: 1573-2517 ; DOI: 10.1016/j.jad.2011.03.010
Link: https://www.sciencedirect.com/science/article/pii/S0165032711000930
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recordid: elsevier_sdoi_10_1016_j_jad_2011_03_010
title: Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: Replications and implications for resolving inconsistent results
format: Article
creator:
  • Uher, Rudolf
  • Caspi, Avshalom
  • Houts, Renate
  • Sugden, Karen
  • Williams, Benjamin
  • Poulton, Richie
  • Moffitt, Terrie E
subjects:
  • Depression
  • Persistent Course
  • Gene–Environment Interactions
  • Serotonin Transporter
  • Childhood Maltreatment
ispartof: Journal of Affective Disorders, December 2011, Vol.135(1-3), pp.56-65
description: Genetic and environmental factors shape life-long vulnerability to depression, but most gene–environment interaction (G × E) research has focused on cross-sectional assessments rather than life-course phenotypes. This study tests the hypothesis that the G × E involving the length polymorphism in the serotonin-transporter-gene-linked-promoter-region ( ) and childhood maltreatment is specific to depression that runs a persistent course in adulthood. The hypothesis is tested in two cohorts. Men and women in the Dunedin Study (N = 847), New Zealand, followed to age 32 years with 96% retention and women in the E-Risk Study (N = 930), England, followed to age 40 years with 96% retention. Diagnoses of past-year major depressive episode were established at four...
language: eng
source:
identifier: ISSN: 0165-0327 ; E-ISSN: 1573-2517 ; DOI: 10.1016/j.jad.2011.03.010
fulltext: fulltext
issn:
  • 0165-0327
  • 01650327
  • 1573-2517
  • 15732517
url: Link


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titleSerotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: Replications and implications for resolving inconsistent results
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descriptionGenetic and environmental factors shape life-long vulnerability to depression, but most gene–environment interaction (G × E) research has focused on cross-sectional assessments rather than life-course phenotypes. This study tests the hypothesis that the G × E involving the length polymorphism in the serotonin-transporter-gene-linked-promoter-region ( ) and childhood maltreatment is specific to depression that runs a persistent course in adulthood. The hypothesis is tested in two cohorts. Men and women in the Dunedin Study (N = 847), New Zealand, followed to age 32 years with 96% retention and women in the E-Risk Study (N = 930), England, followed to age 40 years with 96% retention. Diagnoses of past-year major depressive episode were established at four...
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