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Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents

In a community sample of low-income African American adolescents, we tested the interactive effects of variation in the 1 (OPRM1) gene and the occurrence of stressful life events on symptoms of depression. Interactive effects of 24 OPRM1 simple nucleotide polymorphisms (SNP) and adolescent report of... Full description

Journal Title: Journal of Affective Disorders 20 June 2014, Vol.162, pp.12-19
Main Author: Swann, Gregory
Other Authors: Byck, Gayle R , Dick, Danielle M , Aliev, Fazil , Latendresse, Shawn J , Riley, Brien , Kertes, Darlene , Sun, Cuie , Salvatore, Jessica E , Bolland, John , Mustanski, Brian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0165-0327 ; E-ISSN: 1573-2517 ; DOI: 10.1016/j.jad.2014.03.020
Link: https://www.sciencedirect.com/science/article/pii/S0165032714001311
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recordid: elsevier_sdoi_10_1016_j_jad_2014_03_020
title: Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents
format: Article
creator:
  • Swann, Gregory
  • Byck, Gayle R
  • Dick, Danielle M
  • Aliev, Fazil
  • Latendresse, Shawn J
  • Riley, Brien
  • Kertes, Darlene
  • Sun, Cuie
  • Salvatore, Jessica E
  • Bolland, John
  • Mustanski, Brian
subjects:
  • Molecular Genetics
  • Adolescence
  • Stress
  • Psychopathology
  • Depression
  • Gene×Environment Interactions
ispartof: Journal of Affective Disorders, 20 June 2014, Vol.162, pp.12-19
description: In a community sample of low-income African American adolescents, we tested the interactive effects of variation in the 1 (OPRM1) gene and the occurrence of stressful life events on symptoms of depression. Interactive effects of 24 OPRM1 simple nucleotide polymorphisms (SNP) and adolescent report of stressful life events on depression were tested using multilevel regressions. SNPs were dummy coded to test both additive and dominate forms of coding. Five OPRM1 SNPs showed significant evidence of interaction with stressful life events to alter depression risk (or symptoms) after adjusting for multiple testing and the correlated nature of the SNPs. Follow-up analyses showed significant differences based on OPRM1 genotype at both lower and higher frequencies of stressful life events, suggesting that participants with a copy of the minor allele on OPRM1 SNPs rs524731, rs9478503, rs3778157, rs10485057, and rs511420 have fewer symptoms in low stress conditions but more symptoms in high stress conditions compared to major allele homozygotes. The genetic variants associated with depression in African American adolescents may not translate to other ethnic groups. This study is also limited in that only one gene that functions within a complex biological system is addressed. This current study is the first to find an interaction between OPRM1 and life stress that is associated with depression. It also addressed an understudied population within the behavioral genetics literature. Further research should test additional genes involved in the opioid system and expand the current findings to more diverse samples.
language: eng
source:
identifier: ISSN: 0165-0327 ; E-ISSN: 1573-2517 ; DOI: 10.1016/j.jad.2014.03.020
fulltext: fulltext
issn:
  • 0165-0327
  • 01650327
  • 1573-2517
  • 15732517
url: Link


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titleEffect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents
creatorSwann, Gregory ; Byck, Gayle R ; Dick, Danielle M ; Aliev, Fazil ; Latendresse, Shawn J ; Riley, Brien ; Kertes, Darlene ; Sun, Cuie ; Salvatore, Jessica E ; Bolland, John ; Mustanski, Brian
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subjectMolecular Genetics ; Adolescence ; Stress ; Psychopathology ; Depression ; Gene×Environment Interactions
descriptionIn a community sample of low-income African American adolescents, we tested the interactive effects of variation in the 1 (OPRM1) gene and the occurrence of stressful life events on symptoms of depression. Interactive effects of 24 OPRM1 simple nucleotide polymorphisms (SNP) and adolescent report of stressful life events on depression were tested using multilevel regressions. SNPs were dummy coded to test both additive and dominate forms of coding. Five OPRM1 SNPs showed significant evidence of interaction with stressful life events to alter depression risk (or symptoms) after adjusting for multiple testing and the correlated nature of the SNPs. Follow-up analyses showed significant differences based on OPRM1 genotype at both lower and higher frequencies of stressful life events, suggesting that participants with a copy of the minor allele on OPRM1 SNPs rs524731, rs9478503, rs3778157, rs10485057, and rs511420 have fewer symptoms in low stress conditions but more symptoms in high stress conditions compared to major allele homozygotes. The genetic variants associated with depression in African American adolescents may not translate to other ethnic groups. This study is also limited in that only one gene that functions within a complex biological system is addressed. This current study is the first to find an interaction between OPRM1 and life stress that is associated with depression. It also addressed an understudied population within the behavioral genetics literature. Further research should test additional genes involved in the opioid system and expand the current findings to more diverse samples.
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