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Mechanical properties of porcine brain tissue in vivo and ex vivo estimated by MR elastography

The mechanical properties of brain tissue in vivo determine the response of the brain to rapid skull acceleration. These properties are thus of great interest to the developers of mathematical models of traumatic brain injury (TBI) or neurosurgical simulations. Animal models provide valuable insight... Full description

Journal Title: Journal of Biomechanics 01 March 2018, Vol.69, pp.10-18
Main Author: Guertler, Charlotte A
Other Authors: Okamoto, Ruth J , Schmidt, John L , Badachhape, Andrew A , Johnson, Curtis L , Bayly, Philip V
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0021-9290 ; E-ISSN: 1873-2380 ; DOI: 10.1016/j.jbiomech.2018.01.016
Link: http://dx.doi.org/10.1016/j.jbiomech.2018.01.016
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recordid: elsevier_sdoi_10_1016_j_jbiomech_2018_01_016
title: Mechanical properties of porcine brain tissue in vivo and ex vivo estimated by MR elastography
format: Article
creator:
  • Guertler, Charlotte A
  • Okamoto, Ruth J
  • Schmidt, John L
  • Badachhape, Andrew A
  • Johnson, Curtis L
  • Bayly, Philip V
subjects:
  • Magnetic Resonance Elastography
  • Brain Tissue Stiffness
  • Shear Modulus
  • Post-Mortem Tissue Changes
  • Porcine Brain
  • Magnetic Resonance Elastography
  • Brain Tissue Stiffness
  • Shear Modulus
  • Post-Mortem Tissue Changes
  • Porcine Brain
  • Medicine
  • Engineering
  • Anatomy & Physiology
ispartof: Journal of Biomechanics, 01 March 2018, Vol.69, pp.10-18
description: The mechanical properties of brain tissue in vivo determine the response of the brain to rapid skull acceleration. These properties are thus of great interest to the developers of mathematical models of traumatic brain injury (TBI) or neurosurgical simulations. Animal models provide valuable insight that can improve TBI modeling. In this study we compare estimates of mechanical properties of the Yucatan mini-pig brain in vivo and ex vivo using magnetic resonance elastography (MRE) at multiple frequencies. MRE allows estimations of properties in soft tissue, either in vivo or ex vivo, by imaging harmonic shear wave propagation. Most direct measurements of brain mechanical properties have been performed using samples of brain tissue ex vivo. It has been observed that direct estimates of brain mechanical properties depend on the frequency and amplitude of loading, as well as the time post-mortem and condition of the sample. Using MRE in the same animals at overlapping frequencies,...
language: eng
source:
identifier: ISSN: 0021-9290 ; E-ISSN: 1873-2380 ; DOI: 10.1016/j.jbiomech.2018.01.016
fulltext: no_fulltext
issn:
  • 0021-9290
  • 00219290
  • 1873-2380
  • 18732380
url: Link


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titleMechanical properties of porcine brain tissue in vivo and ex vivo estimated by MR elastography
creatorGuertler, Charlotte A ; Okamoto, Ruth J ; Schmidt, John L ; Badachhape, Andrew A ; Johnson, Curtis L ; Bayly, Philip V
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subjectMagnetic Resonance Elastography ; Brain Tissue Stiffness ; Shear Modulus ; Post-Mortem Tissue Changes ; Porcine Brain ; Magnetic Resonance Elastography ; Brain Tissue Stiffness ; Shear Modulus ; Post-Mortem Tissue Changes ; Porcine Brain ; Medicine ; Engineering ; Anatomy & Physiology
descriptionThe mechanical properties of brain tissue in vivo determine the response of the brain to rapid skull acceleration. These properties are thus of great interest to the developers of mathematical models of traumatic brain injury (TBI) or neurosurgical simulations. Animal models provide valuable insight that can improve TBI modeling. In this study we compare estimates of mechanical properties of the Yucatan mini-pig brain in vivo and ex vivo using magnetic resonance elastography (MRE) at multiple frequencies. MRE allows estimations of properties in soft tissue, either in vivo or ex vivo, by imaging harmonic shear wave propagation. Most direct measurements of brain mechanical properties have been performed using samples of brain tissue ex vivo. It has been observed that direct estimates of brain mechanical properties depend on the frequency and amplitude of loading, as well as the time post-mortem and condition of the sample. Using MRE in the same animals at overlapping frequencies,...
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The mechanical properties of brain tissue in vivo determine the response of the brain to rapid skull acceleration. These properties are thus of great interest to the developers of mathematical models of traumatic brain injury (TBI) or neurosurgical simulations. Animal models provide valuable insight that can improve TBI modeling. In this study we compare estimates of mechanical properties of the Yucatan mini-pig brain in vivo and ex vivo using magnetic resonance elastography (MRE) at multiple frequencies. MRE allows estimations of properties in soft tissue, either in vivo or ex vivo, by imaging harmonic shear wave propagation. Most direct measurements of brain mechanical properties have been performed using samples of brain tissue ex vivo. It has been observed that direct estimates of brain mechanical properties depend on the frequency and amplitude of loading, as well as the time post-mortem and condition of the sample. Using MRE in the same animals at overlapping frequencies,...

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The mechanical properties of brain tissue in vivo determine the response of the brain to rapid skull acceleration. These properties are thus of great interest to the developers of mathematical models of traumatic brain injury (TBI) or neurosurgical simulations. Animal models provide valuable insight that can improve TBI modeling. In this study we compare estimates of mechanical properties of the Yucatan mini-pig brain in vivo and ex vivo using magnetic resonance elastography (MRE) at multiple frequencies. MRE allows estimations of properties in soft tissue, either in vivo or ex vivo, by imaging harmonic shear wave propagation. Most direct measurements of brain mechanical properties have been performed using samples of brain tissue ex vivo. It has been observed that direct estimates of brain mechanical properties depend on the frequency and amplitude of loading, as well as the time post-mortem and condition of the sample. Using MRE in the same animals at overlapping frequencies,...

pubElsevier Ltd
doi10.1016/j.jbiomech.2018.01.016
lad01Journal of Biomechanics
date2018-03-01