schliessen

Filtern

 

Bibliotheken

Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy

B7H3 immunogene therapy is able to completely eradicate tumors when combined with an anti-vascular agent. The aim of this study was to determine whether vasostatin, a potent anti-angiogenic agent, could synergize with B7H3-mediated immunotherapy to combat hepatocellular carcinoma (HCC). Vasostatin a... Full description

Journal Title: Journal of Hepatology 2007, Vol.46(1), pp.98-106
Main Author: Ma, Lixin
Other Authors: Luo, Liqiong , Qiao, Haiquan , Dong, Xuesong , Pan, Shangha , Jiang, Hongchi , Krissansen, Geoffrey W , Sun, Xueying
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0168-8278 ; E-ISSN: 1600-0641 ; DOI: 10.1016/j.jhep.2006.07.031
Link: https://www.sciencedirect.com/science/article/pii/S0168827806004624
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_jhep_2006_07_031
title: Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy
format: Article
creator:
  • Ma, Lixin
  • Luo, Liqiong
  • Qiao, Haiquan
  • Dong, Xuesong
  • Pan, Shangha
  • Jiang, Hongchi
  • Krissansen, Geoffrey W
  • Sun, Xueying
subjects:
  • Vasostatin
  • B7h3
  • Hepatocellular Carcinoma
  • Angiogenesis
  • Immunotherapy
  • Medicine
ispartof: Journal of Hepatology, 2007, Vol.46(1), pp.98-106
description: B7H3 immunogene therapy is able to completely eradicate tumors when combined with an anti-vascular agent. The aim of this study was to determine whether vasostatin, a potent anti-angiogenic agent, could synergize with B7H3-mediated immunotherapy to combat hepatocellular carcinoma (HCC). Vasostatin and B7H3 expression plasmids were constructed, and the and expression and anti-angiogenic activity of recombinant vasostatin were measured. The anti-tumor activities of B7H3 and vasostatin alone and in combination were assessed using single and multiple H22 tumor models. Gene transfer of vasostatin inhibited the proliferation of aortic endothelial cells, and angiogenesis in the chorioallantoic membrane assay. Subcutaneous H22 tumors established in BALB/c mice were completely eradicated in response to intratumoral injection of B7H3-expressing plasmids followed 24 h later...
language: eng
source:
identifier: ISSN: 0168-8278 ; E-ISSN: 1600-0641 ; DOI: 10.1016/j.jhep.2006.07.031
fulltext: fulltext
issn:
  • 0168-8278
  • 01688278
  • 1600-0641
  • 16000641
url: Link


@attributes
ID1230347581
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_jhep_2006_07_031
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_jhep_2006_07_031
sourcesystemPC
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
13AABNK
14AAEDT
15AAKOC
16AAOAW
17AAQFI
18ABBQC
19ABFNM
20ABMZM
21ABYKQ
22ACDAQ
23ACIUM
24ACRLP
25AEKER
26AEVXI
27AFKWA
28AFTJW
29AFXIZ
30AGHFR
31AGUBO
32AGYEJ
33AHHHB
34AIKHN
35AITUG
36AJBFU
37AJOXV
38AJRQY
39AJUYK
40AMFUW
41ANZVX
42BLXMC
43BNPGV
44EO8
45EO9
46EP2
47EP3
48FDB
49FGOYB
50FIRID
51FNPLU
52G-Q
53GBLVA
54HDZ
55HMK
56HMO
57J1W
58KOM
59LCYCR
60OAUVE
61OC.
62ON0
63P-8
64P-9
65PC.
66Q38
67R2-
68RPZ
69SCC
70SDF
71SDG
72SDP
73SEL
74SES
75SEW
76SSH
77SSZ
78T5K
79UV1
80Z5R
81~G-
pqid68364708
galeid161271756
display
typearticle
titleComplete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy
creatorMa, Lixin ; Luo, Liqiong ; Qiao, Haiquan ; Dong, Xuesong ; Pan, Shangha ; Jiang, Hongchi ; Krissansen, Geoffrey W ; Sun, Xueying
ispartofJournal of Hepatology, 2007, Vol.46(1), pp.98-106
identifier
subjectVasostatin ; B7h3 ; Hepatocellular Carcinoma ; Angiogenesis ; Immunotherapy ; Medicine
descriptionB7H3 immunogene therapy is able to completely eradicate tumors when combined with an anti-vascular agent. The aim of this study was to determine whether vasostatin, a potent anti-angiogenic agent, could synergize with B7H3-mediated immunotherapy to combat hepatocellular carcinoma (HCC). Vasostatin and B7H3 expression plasmids were constructed, and the and expression and anti-angiogenic activity of recombinant vasostatin were measured. The anti-tumor activities of B7H3 and vasostatin alone and in combination were assessed using single and multiple H22 tumor models. Gene transfer of vasostatin inhibited the proliferation of aortic endothelial cells, and angiogenesis in the chorioallantoic membrane assay. Subcutaneous H22 tumors established in BALB/c mice were completely eradicated in response to intratumoral injection of B7H3-expressing plasmids followed 24 h later...
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0168827806004624$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Ma, Lixin
1Luo, Liqiong
2Qiao, Haiquan
3Dong, Xuesong
4Pan, Shangha
5Jiang, Hongchi
6Krissansen, Geoffrey W
7Sun, Xueying
titleComplete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy
description
subject
0Vasostatin
1B7h3
2Hepatocellular Carcinoma
3Angiogenesis
4Immunotherapy
5Medicine
general
0English
1Elsevier B.V
210.1016/j.jhep.2006.07.031
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_jhep_2006_07_031
issn
00168-8278
101688278
21600-0641
316000641
rsrctypearticle
creationdate2007
addtitleJournal of Hepatology
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
13AABNK
14AAEDT
15AAKOC
16AAOAW
17AAQFI
18ABBQC
19ABFNM
20ABMZM
21ABYKQ
22ACDAQ
23ACIUM
24ACRLP
25AEKER
26AEVXI
27AFKWA
28AFTJW
29AFXIZ
30AGHFR
31AGUBO
32AGYEJ
33AHHHB
34AIKHN
35AITUG
36AJBFU
37AJOXV
38AJRQY
39AJUYK
40AMFUW
41ANZVX
42BLXMC
43BNPGV
44EO8
45EO9
46EP2
47EP3
48FDB
49FGOYB
50FIRID
51FNPLU
52G-Q
53GBLVA
54HDZ
55HMK
56HMO
57J1W
58KOM
59LCYCR
60OAUVE
61OC.
62ON0
63P-8
64P-9
65PC.
66Q38
67R2-
68RPZ
69SCC
70SDF
71SDG
72SDP
73SEL
74SES
75SEW
76SSH
77SSZ
78T5K
79UV1
80Z5R
81~G-
startdate20070101
enddate20071231
lsr40Journal of Hepatology, 2007, Vol.46 (1), pp.98-106
doi10.1016/j.jhep.2006.07.031
citationpf 98 pt 106 vol 46 issue 1
lsr30VSR-Enriched:[pqid, galeid]
sort
titleComplete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy
authorMa, Lixin ; Luo, Liqiong ; Qiao, Haiquan ; Dong, Xuesong ; Pan, Shangha ; Jiang, Hongchi ; Krissansen, Geoffrey W ; Sun, Xueying
creationdate20070000
lso0120070000
facets
frbrgroupid7220948197055814576
frbrtype5
newrecords20190904
languageeng
topic
0Vasostatin
1B7h3
2Hepatocellular Carcinoma
3Angiogenesis
4Immunotherapy
5Medicine
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Ma, Lixin
1Luo, Liqiong
2Qiao, Haiquan
3Dong, Xuesong
4Pan, Shangha
5Jiang, Hongchi
6Krissansen, Geoffrey W
7Sun, Xueying
jtitleJournal of Hepatology
creationdate2007
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Ma
1Luo
2Qiao
3Dong
4Pan
5Jiang
6Krissansen
7Sun
aufirst
0Lixin
1Liqiong
2Haiquan
3Xuesong
4Shangha
5Hongchi
6Geoffrey W
7Xueying
auinitL
auinit1L
au
0Ma, Lixin
1Luo, Liqiong
2Qiao, Haiquan
3Dong, Xuesong
4Pan, Shangha
5Jiang, Hongchi
6Krissansen, Geoffrey W
7Sun, Xueying
atitleComplete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy
jtitleJournal of Hepatology
date2007
risdate2007
volume46
issue1
spage98
epage106
pages98-106
issn0168-8278
eissn1600-0641
formatjournal
genrearticle
ristypeJOUR
abstract
pubElsevier B.V
doi10.1016/j.jhep.2006.07.031
lad01Journal of Hepatology