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Use of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy

[Display omitted] Repeated hepatectomy is widely accepted as one of the most effective curative treatment for recurrent hepatocellular carcinoma or liver metastasis from colorectal cancer. It has, however, two critical issues; postoperative adhesion and decrease of liver regenerative capacity. Posto... Full description

Journal Title: Journal of Hepatology May 2015, Vol.62(5), pp.1141-1147
Main Author: Inagaki, Natsuko F
Other Authors: Inagaki, Fuyuki F , Kokudo, Norihiro , Miyajima, Atsushi
Format: Electronic Article Electronic Article
Language: English
Subjects:
Hcc
Phx
Ast
Alt
Pod
Gfp
Tpa
Hgf
ID: ISSN: 0168-8278 ; E-ISSN: 1600-0641 ; DOI: 10.1016/j.jhep.2014.12.010
Link: http://dx.doi.org/10.1016/j.jhep.2014.12.010
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recordid: elsevier_sdoi_10_1016_j_jhep_2014_12_010
title: Use of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy
format: Article
creator:
  • Inagaki, Natsuko F
  • Inagaki, Fuyuki F
  • Kokudo, Norihiro
  • Miyajima, Atsushi
subjects:
  • Hepatopancreatobiliary Surgery
  • Regenerative Medicine
  • Cell Sheet
  • Liver Resection
  • Transplantation
  • Fl-Mcs
  • P-Mcs
  • Hcc
  • Phx
  • Pphx
  • Ast
  • Alt
  • Pod
  • Gfp
  • Pclp1
  • Msln
  • Tpa
  • Pai-1
  • Hgf
  • Il-6
ispartof: Journal of Hepatology, May 2015, Vol.62(5), pp.1141-1147
description: [Display omitted] Repeated hepatectomy is widely accepted as one of the most effective curative treatment for recurrent hepatocellular carcinoma or liver metastasis from colorectal cancer. It has, however, two critical issues; postoperative adhesion and decrease of liver regenerative capacity. Postoperative adhesion makes surgical operations technically more demanding, leading to increased mortality and morbidity rates. Although the liver has a remarkable regenerative ability, volume and functional restoration after multiple repeated hepatectomy is not generally complete. So a new procedure that overcomes these two issues is required. We examined if a fetal liver mesothelial cells (FL-MCs) sheet could solve these two clinical issues simultaneously. We established a novel mouse hepatectomy model that reproduces postoperative adhesion on the resected liver surface. We isolated FL-MCs from mouse fetal liver and prepared a cell sheet. The FL-MCs...
language: eng
source:
identifier: ISSN: 0168-8278 ; E-ISSN: 1600-0641 ; DOI: 10.1016/j.jhep.2014.12.010
fulltext: fulltext
issn:
  • 0168-8278
  • 01688278
  • 1600-0641
  • 16000641
url: Link


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titleUse of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy
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subjectHepatopancreatobiliary Surgery ; Regenerative Medicine ; Cell Sheet ; Liver Resection ; Transplantation ; Fl-Mcs ; P-Mcs ; Hcc ; Phx ; Pphx ; Ast ; Alt ; Pod ; Gfp ; Pclp1 ; Msln ; Tpa ; Pai-1 ; Hgf ; Il-6
description[Display omitted] Repeated hepatectomy is widely accepted as one of the most effective curative treatment for recurrent hepatocellular carcinoma or liver metastasis from colorectal cancer. It has, however, two critical issues; postoperative adhesion and decrease of liver regenerative capacity. Postoperative adhesion makes surgical operations technically more demanding, leading to increased mortality and morbidity rates. Although the liver has a remarkable regenerative ability, volume and functional restoration after multiple repeated hepatectomy is not generally complete. So a new procedure that overcomes these two issues is required. We examined if a fetal liver mesothelial cells (FL-MCs) sheet could solve these two clinical issues simultaneously. We established a novel mouse hepatectomy model that reproduces postoperative adhesion on the resected liver surface. We isolated FL-MCs from mouse fetal liver and prepared a cell sheet. The FL-MCs...
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titleUse of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy
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[Display omitted]

Repeated hepatectomy is widely accepted as one of the most effective curative treatment for recurrent hepatocellular carcinoma or liver metastasis from colorectal cancer. It has, however, two critical issues; postoperative adhesion and decrease of liver regenerative capacity. Postoperative adhesion makes surgical operations technically more demanding, leading to increased mortality and morbidity rates. Although the liver has a remarkable regenerative ability, volume and functional restoration after multiple repeated hepatectomy is not generally complete. So a new procedure that overcomes these two issues is required. We examined if a fetal liver mesothelial cells (FL-MCs) sheet could solve these two clinical issues simultaneously.

We established a novel mouse hepatectomy model that reproduces postoperative adhesion on the resected liver surface. We isolated FL-MCs from mouse fetal liver and prepared a cell sheet. The FL-MCs...

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[Display omitted]

Repeated hepatectomy is widely accepted as one of the most effective curative treatment for recurrent hepatocellular carcinoma or liver metastasis from colorectal cancer. It has, however, two critical issues; postoperative adhesion and decrease of liver regenerative capacity. Postoperative adhesion makes surgical operations technically more demanding, leading to increased mortality and morbidity rates. Although the liver has a remarkable regenerative ability, volume and functional restoration after multiple repeated hepatectomy is not generally complete. So a new procedure that overcomes these two issues is required. We examined if a fetal liver mesothelial cells (FL-MCs) sheet could solve these two clinical issues simultaneously.

We established a novel mouse hepatectomy model that reproduces postoperative adhesion on the resected liver surface. We isolated FL-MCs from mouse fetal liver and prepared a cell sheet. The FL-MCs...

pubElsevier B.V
doi10.1016/j.jhep.2014.12.010
lad01Journal of Hepatology
date2015-05