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Clinical implications of basic research in hepatocellular carcinoma

A 58-year old Caucasian female has compensated hepatitis C related cirrhosis. Her surveillance ultrasound showed hypodense liver nodules and subsequent triple phase CT scan showed five tumor nodules with diameters ranging from 3–5cms involving both hepatic lobes. The nodules showed characteristic ra... Full description

Journal Title: Journal of Hepatology March 2016, Vol.64(3), pp.736-745
Main Author: Dhanasekaran, Renumathy
Other Authors: Venkatesh, Sudhakar K , Torbenson, Michael S , Roberts, Lewis R
Format: Electronic Article Electronic Article
Language: English
Subjects:
Hcc
Hcc
ID: ISSN: 0168-8278 ; E-ISSN: 1600-0641 ; DOI: 10.1016/j.jhep.2015.09.008
Link: http://dx.doi.org/10.1016/j.jhep.2015.09.008
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recordid: elsevier_sdoi_10_1016_j_jhep_2015_09_008
title: Clinical implications of basic research in hepatocellular carcinoma
format: Article
creator:
  • Dhanasekaran, Renumathy
  • Venkatesh, Sudhakar K
  • Torbenson, Michael S
  • Roberts, Lewis R
subjects:
  • Hcc
  • Basic Research
  • Clinical
  • Hcc
  • Basic Research
  • Clinical
  • Medicine
ispartof: Journal of Hepatology, March 2016, Vol.64(3), pp.736-745
description: A 58-year old Caucasian female has compensated hepatitis C related cirrhosis. Her surveillance ultrasound showed hypodense liver nodules and subsequent triple phase CT scan showed five tumor nodules with diameters ranging from 3–5cms involving both hepatic lobes. The nodules showed characteristic radiologic findings on the CT scan and she was diagnosed with hepatocellular carcinoma (HCC) based on non-invasive criteria. There was also associated right portal vein tumor thrombosis. Her functional capacity at diagnosis was slightly limited, but she was capable of performing all activities of daily living and self-care. Her laboratory tests at diagnosis were as follows: sodium 129mmol/L, potassium 3.6mmol/L, blood urea nitrogen 22mg/dL, creatinine 1.0mg/dL, albumin 2.9g/dl, bilirubin 1.8mg/dl, alanine aminotransferase 87U/L, aspartate aminotransferase 68U/L, alkaline phosphatase 139U/L, white blood cell 3.5x109/L, hemoglobin 10.4, platelet count 73x109/L, international normalized...
language: eng
source:
identifier: ISSN: 0168-8278 ; E-ISSN: 1600-0641 ; DOI: 10.1016/j.jhep.2015.09.008
fulltext: fulltext
issn:
  • 0168-8278
  • 01688278
  • 1600-0641
  • 16000641
url: Link


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descriptionA 58-year old Caucasian female has compensated hepatitis C related cirrhosis. Her surveillance ultrasound showed hypodense liver nodules and subsequent triple phase CT scan showed five tumor nodules with diameters ranging from 3–5cms involving both hepatic lobes. The nodules showed characteristic radiologic findings on the CT scan and she was diagnosed with hepatocellular carcinoma (HCC) based on non-invasive criteria. There was also associated right portal vein tumor thrombosis. Her functional capacity at diagnosis was slightly limited, but she was capable of performing all activities of daily living and self-care. Her laboratory tests at diagnosis were as follows: sodium 129mmol/L, potassium 3.6mmol/L, blood urea nitrogen 22mg/dL, creatinine 1.0mg/dL, albumin 2.9g/dl, bilirubin 1.8mg/dl, alanine aminotransferase 87U/L, aspartate aminotransferase 68U/L, alkaline phosphatase 139U/L, white blood cell 3.5x109/L, hemoglobin 10.4, platelet count 73x109/L, international normalized...
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A 58-year old Caucasian female has compensated hepatitis C related cirrhosis. Her surveillance ultrasound showed hypodense liver nodules and subsequent triple phase CT scan showed five tumor nodules with diameters ranging from 3–5cms involving both hepatic lobes. The nodules showed characteristic radiologic findings on the CT scan and she was diagnosed with hepatocellular carcinoma (HCC) based on non-invasive criteria. There was also associated right portal vein tumor thrombosis. Her functional capacity at diagnosis was slightly limited, but she was capable of performing all activities of daily living and self-care. Her laboratory tests at diagnosis were as follows: sodium 129mmol/L, potassium 3.6mmol/L, blood urea nitrogen 22mg/dL, creatinine 1.0mg/dL, albumin 2.9g/dl, bilirubin 1.8mg/dl, alanine aminotransferase 87U/L, aspartate aminotransferase 68U/L, alkaline phosphatase 139U/L, white blood cell 3.5x109/L, hemoglobin 10.4, platelet count 73x109/L, international normalized...

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