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Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis

A disintegrin and metalloprotease 8 (ADAM8) is a trans-membrane protein, which is involved in cell adhesion, signaling and migration as well as the proteolytic cleavage of various substrates. Endostatin is a potent inhibitor of angiogenesis. ADAM8 and Endostatin have been associated with multiple ma... Full description

Journal Title: Journal of the Egyptian National Cancer Institute March 2015, Vol.27(1), pp.1-9
Main Author: Abd El-Rehim, Dalia M
Other Authors: Osman, Nisreen A.A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1110-0362 ; DOI: 10.1016/j.jnci.2014.11.001
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recordid: elsevier_sdoi_10_1016_j_jnci_2014_11_001
title: Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis
format: Article
creator:
  • Abd El-Rehim, Dalia M
  • Osman, Nisreen A.A
subjects:
  • Osteosarcoma
  • Adam8
  • Endostatin
  • Immunohistochemistry
  • Osteosarcoma
  • Adam8
  • Endostatin
  • Immunohistochemistry
  • Medicine
ispartof: Journal of the Egyptian National Cancer Institute, March 2015, Vol.27(1), pp.1-9
description: A disintegrin and metalloprotease 8 (ADAM8) is a trans-membrane protein, which is involved in cell adhesion, signaling and migration as well as the proteolytic cleavage of various substrates. Endostatin is a potent inhibitor of angiogenesis. ADAM8 and Endostatin have been associated with multiple malignancies. However, their role in osteosarcoma is not fully elucidated. To determine the expression of ADAM8 and endostatin in osteosarcoma and to study their correlation with different clinicopathological parameters and patients’ outcomes. ADAM8 and endostatin expression were immunohistochemically evaluated in 61 primary osteosarcomas and 11 pulmonary metastatic osteosarcoma lesions. Among 61 primary osteosarcomas, ADAM8 was detected in 52 tumors (85.2%) and highly expressed in 33 cases (54.1%). Positive endostatin expression was found in 28 tumors (45.9%). Higher ADAM8 and decreased endostatin expression rates in metastatic...
language: eng
source:
identifier: ISSN: 1110-0362 ; DOI: 10.1016/j.jnci.2014.11.001
fulltext: fulltext
issn:
  • 1110-0362
  • 11100362
url: Link


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titleExpression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis
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identifierISSN: 1110-0362 ; DOI: 10.1016/j.jnci.2014.11.001
subjectOsteosarcoma ; Adam8 ; Endostatin ; Immunohistochemistry ; Osteosarcoma ; Adam8 ; Endostatin ; Immunohistochemistry ; Medicine
descriptionA disintegrin and metalloprotease 8 (ADAM8) is a trans-membrane protein, which is involved in cell adhesion, signaling and migration as well as the proteolytic cleavage of various substrates. Endostatin is a potent inhibitor of angiogenesis. ADAM8 and Endostatin have been associated with multiple malignancies. However, their role in osteosarcoma is not fully elucidated. To determine the expression of ADAM8 and endostatin in osteosarcoma and to study their correlation with different clinicopathological parameters and patients’ outcomes. ADAM8 and endostatin expression were immunohistochemically evaluated in 61 primary osteosarcomas and 11 pulmonary metastatic osteosarcoma lesions. Among 61 primary osteosarcomas, ADAM8 was detected in 52 tumors (85.2%) and highly expressed in 33 cases (54.1%). Positive endostatin expression was found in 28 tumors (45.9%). Higher ADAM8 and decreased endostatin expression rates in metastatic...
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