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Vitamin D–gene interactions in multiple sclerosis

Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple... Full description

Journal Title: Journal of the Neurological Sciences 15 December 2011, Vol.311(1-2), pp.32-36
Main Author: Berlanga-Taylor, Antonio J
Other Authors: Disanto, Giulio , Ebers, George C , Ramagopalan, Sreeram V
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-510X ; E-ISSN: 1878-5883 ; DOI: 10.1016/j.jns.2011.08.041
Link: http://dx.doi.org/10.1016/j.jns.2011.08.041
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recordid: elsevier_sdoi_10_1016_j_jns_2011_08_041
title: Vitamin D–gene interactions in multiple sclerosis
format: Article
creator:
  • Berlanga-Taylor, Antonio J
  • Disanto, Giulio
  • Ebers, George C
  • Ramagopalan, Sreeram V
subjects:
  • Vitamin D
  • Multiple Sclerosis
  • Gene–Environment Interactions
  • Vitamin D
  • Multiple Sclerosis
  • Gene–Environment Interactions
  • Medicine
ispartof: Journal of the Neurological Sciences, 15 December 2011, Vol.311(1-2), pp.32-36
description: Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.
language: eng
source:
identifier: ISSN: 0022-510X ; E-ISSN: 1878-5883 ; DOI: 10.1016/j.jns.2011.08.041
fulltext: fulltext
issn:
  • 0022-510X
  • 0022510X
  • 1878-5883
  • 18785883
url: Link


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subjectVitamin D ; Multiple Sclerosis ; Gene–Environment Interactions ; Vitamin D ; Multiple Sclerosis ; Gene–Environment Interactions ; Medicine
descriptionVitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.
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Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.

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Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.

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