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Upregulation of spinal NMDA receptors mediates hydrogen sulfide-induced hyperalgesia

Hydrogen sulfide (H2S) is an endogenous neurotransmitter that importantly regulates various physiological and pathological events including pain signal transduction. In this study, we investigated the role of spinal NMDA receptors in the nociception induced by intraplantar injection of NaHS, an H2S... Full description

Journal Title: Journal of the Neurological Sciences 15 April 2016, Vol.363, pp.176-181
Main Author: Zhao, Shuang
Other Authors: Liu, Fei-Fei , Wu, Yu-Ming , Jiang, Yu-Qing , Guo, Yue-Xian , Wang, Xiu-Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-510X ; E-ISSN: 1878-5883 ; DOI: 10.1016/j.jns.2016.02.058
Link: https://www.sciencedirect.com/science/article/pii/S0022510X16301228
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recordid: elsevier_sdoi_10_1016_j_jns_2016_02_058
title: Upregulation of spinal NMDA receptors mediates hydrogen sulfide-induced hyperalgesia
format: Article
creator:
  • Zhao, Shuang
  • Liu, Fei-Fei
  • Wu, Yu-Ming
  • Jiang, Yu-Qing
  • Guo, Yue-Xian
  • Wang, Xiu-Li
subjects:
  • Hydrogen Sulfide
  • Hyperalgesia
  • Nmda Receptor
  • Spinal Cord
  • Pain
  • Dorsal Root Ganglion
  • Medicine
ispartof: Journal of the Neurological Sciences, 15 April 2016, Vol.363, pp.176-181
description: Hydrogen sulfide (H2S) is an endogenous neurotransmitter that importantly regulates various physiological and pathological events including pain signal transduction. In this study, we investigated the role of spinal NMDA receptors in the nociception induced by intraplantar injection of NaHS, an H2S donor. Intraplantar injection of NaHS into hindpaw significantly decreased the paw withdrawal threshold (PWT) in contralateral hindpaw. However, intraplantar formalin injection did not produce PWT in contralateral hindpaw. Intrathecal injection of methemoglobin, a H2S scavenger, abolished hyperalgesia induced by NaHS. In addition, NaHS-induced hyperalgesia was partly, but significantly, attenuated by intrathecal injection of hydroxylamine, a cystathionine-β-synthase (CBS) inhibitor. RT-PCR and western blotting analysis revealed that NR2B mRNA and protein levels were increased in the spinal dorsal horn, but not in dorsal root ganglion (DRG) in rats subjected to NaHS intraplantar injection. Collectively, these data suggest that peripheral injection of H2S donor causes hyperalgesia through increase in NR2B expression and production of H2S in the spinal cord.
language: eng
source:
identifier: ISSN: 0022-510X ; E-ISSN: 1878-5883 ; DOI: 10.1016/j.jns.2016.02.058
fulltext: fulltext
issn:
  • 0022-510X
  • 0022510X
  • 1878-5883
  • 18785883
url: Link


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titleUpregulation of spinal NMDA receptors mediates hydrogen sulfide-induced hyperalgesia
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subjectHydrogen Sulfide ; Hyperalgesia ; Nmda Receptor ; Spinal Cord ; Pain ; Dorsal Root Ganglion ; Medicine
descriptionHydrogen sulfide (H2S) is an endogenous neurotransmitter that importantly regulates various physiological and pathological events including pain signal transduction. In this study, we investigated the role of spinal NMDA receptors in the nociception induced by intraplantar injection of NaHS, an H2S donor. Intraplantar injection of NaHS into hindpaw significantly decreased the paw withdrawal threshold (PWT) in contralateral hindpaw. However, intraplantar formalin injection did not produce PWT in contralateral hindpaw. Intrathecal injection of methemoglobin, a H2S scavenger, abolished hyperalgesia induced by NaHS. In addition, NaHS-induced hyperalgesia was partly, but significantly, attenuated by intrathecal injection of hydroxylamine, a cystathionine-β-synthase (CBS) inhibitor. RT-PCR and western blotting analysis revealed that NR2B mRNA and protein levels were increased in the spinal dorsal horn, but not in dorsal root ganglion (DRG) in rats subjected to NaHS intraplantar injection. Collectively, these data suggest that peripheral injection of H2S donor causes hyperalgesia through increase in NR2B expression and production of H2S in the spinal cord.
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Hydrogen sulfide (H2S) is an endogenous neurotransmitter that importantly regulates various physiological and pathological events including pain signal transduction. In this study, we investigated the role of spinal NMDA receptors in the nociception induced by intraplantar injection of NaHS, an H2S donor. Intraplantar injection of NaHS into hindpaw significantly decreased the paw withdrawal threshold (PWT) in contralateral hindpaw. However, intraplantar formalin injection did not produce PWT in contralateral hindpaw. Intrathecal injection of methemoglobin, a H2S scavenger, abolished hyperalgesia induced by NaHS. In addition, NaHS-induced hyperalgesia was partly, but significantly, attenuated by intrathecal injection of hydroxylamine, a cystathionine-β-synthase (CBS) inhibitor. RT-PCR and western blotting analysis revealed that NR2B mRNA and protein levels were increased in the spinal dorsal horn, but not in dorsal root ganglion (DRG) in rats subjected to NaHS intraplantar injection. Collectively, these data suggest that peripheral injection of H2S donor causes hyperalgesia through increase in NR2B expression and production of H2S in the spinal cord.

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Hydrogen sulfide (H2S) is an endogenous neurotransmitter that importantly regulates various physiological and pathological events including pain signal transduction. In this study, we investigated the role of spinal NMDA receptors in the nociception induced by intraplantar injection of NaHS, an H2S donor. Intraplantar injection of NaHS into hindpaw significantly decreased the paw withdrawal threshold (PWT) in contralateral hindpaw. However, intraplantar formalin injection did not produce PWT in contralateral hindpaw. Intrathecal injection of methemoglobin, a H2S scavenger, abolished hyperalgesia induced by NaHS. In addition, NaHS-induced hyperalgesia was partly, but significantly, attenuated by intrathecal injection of hydroxylamine, a cystathionine-β-synthase (CBS) inhibitor. RT-PCR and western blotting analysis revealed that NR2B mRNA and protein levels were increased in the spinal dorsal horn, but not in dorsal root ganglion (DRG) in rats subjected to NaHS intraplantar injection. Collectively, these data suggest that peripheral injection of H2S donor causes hyperalgesia through increase in NR2B expression and production of H2S in the spinal cord.

pubElsevier B.V
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lad01Journal of the Neurological Sciences
date2016-04-15