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Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jnutbio.2015.01.007 Byline: Diana N. Obanda, Yongmei Yu, Zhong Q. Wang, William T. Cefalu Abstract: This study sought to investigate the effect of calorie restriction (CR) on skeletal muscle sphingolipid metab... Full description

Journal Title: The Journal of Nutritional Biochemistry July 2015, Vol.26(7), pp.687-695
Main Author: Obanda, Diana N
Other Authors: Yu, Yongmei , Wang, Zhong Q , Cefalu, William T
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0955-2863 ; E-ISSN: 1873-4847 ; DOI: 10.1016/j.jnutbio.2015.01.007
Link: https://www.sciencedirect.com/science/article/pii/S0955286315000406
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recordid: elsevier_sdoi_10_1016_j_jnutbio_2015_01_007
title: Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle
format: Article
creator:
  • Obanda, Diana N
  • Yu, Yongmei
  • Wang, Zhong Q
  • Cefalu, William T
subjects:
  • Calorie Restriction
  • Lipids
  • Sphingolipids
  • Glycosphingolipids
  • Insulin Sensitivity
  • Chemistry
  • Anatomy & Physiology
  • Diet & Clinical Nutrition
ispartof: The Journal of Nutritional Biochemistry, July 2015, Vol.26(7), pp.687-695
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jnutbio.2015.01.007 Byline: Diana N. Obanda, Yongmei Yu, Zhong Q. Wang, William T. Cefalu Abstract: This study sought to investigate the effect of calorie restriction (CR) on skeletal muscle sphingolipid metabolism and its contribution to improved insulin action in rats after a 6-month feeding study. Twenty nine (29) male Fischer 344 rats were randomized to an ad libitum (AL) diet or 30% CR. Dietary intake, body weight and insulin sensitivity were monitored. After 6 months, skeletal muscle (vastus lateralis) was obtained for insulin signaling and lipid profiling. CR significantly decreased insulin and glucose levels and also altered the expression and activity of proteins involved in sphingolipid formation and metabolism. The quantities of ceramides significantly increased in CR animals (P
language: eng
source:
identifier: ISSN: 0955-2863 ; E-ISSN: 1873-4847 ; DOI: 10.1016/j.jnutbio.2015.01.007
fulltext: fulltext
issn:
  • 0955-2863
  • 09552863
  • 1873-4847
  • 18734847
url: Link


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titleModulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle
creatorObanda, Diana N ; Yu, Yongmei ; Wang, Zhong Q ; Cefalu, William T
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subjectCalorie Restriction ; Lipids ; Sphingolipids ; Glycosphingolipids ; Insulin Sensitivity ; Chemistry ; Anatomy & Physiology ; Diet & Clinical Nutrition
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jnutbio.2015.01.007 Byline: Diana N. Obanda, Yongmei Yu, Zhong Q. Wang, William T. Cefalu Abstract: This study sought to investigate the effect of calorie restriction (CR) on skeletal muscle sphingolipid metabolism and its contribution to improved insulin action in rats after a 6-month feeding study. Twenty nine (29) male Fischer 344 rats were randomized to an ad libitum (AL) diet or 30% CR. Dietary intake, body weight and insulin sensitivity were monitored. After 6 months, skeletal muscle (vastus lateralis) was obtained for insulin signaling and lipid profiling. CR significantly decreased insulin and glucose levels and also altered the expression and activity of proteins involved in sphingolipid formation and metabolism. The quantities of ceramides significantly increased in CR animals (P<.05; n=14-15), while ceramide metabolism products (i.e., glycosphingolipids: hexosylceramides and lactosylceramides) significantly decreased (P<.05; n=14-15). Ceramide phosphates, sphingomyelins, sphingosine and sphingosine phosphate were not significantly different between AL and CR groups (P=ns; n=14-15). Lactosylceramide quantities correlated significantly with surrogate markers of insulin resistance (homeostasis model of assessment on insulin resistance) (r=0.7; P<.005). Products of ceramide metabolism (glycosphingolipids), known to interfere with insulin signaling at elevated levels, were significantly reduced in the skeletal muscle of CR animals. The increase in insulin sensitivity is associated with glycosphingolipid levels. Article History: Received 1 October 2014; Revised 22 December 2014; Accepted 14 January 2015
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