schliessen

Filtern

 

Bibliotheken

Rs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients

•The first report of AIRE polymorphism in myasthenia gravis (MG).•Significantly higher frequencies of rs3761389G allele in MG group and mild subgroup.•Rs3761389 variant is associated with the susceptibility of MG.•After adjusting for confounders, rs3761389 genotype is not associated with MG severity... Full description

Journal Title: Journal of Clinical Neuroscience June 2017, Vol.40, pp.180-184
Main Author: Zhang, Xu
Other Authors: Ding, Xiao-Jun , Wang, Qi , Yue, Yao-Xian , Xie, Yanchen , Hao, Hong-Jun , Liang, Bing , Zhang, Xian-Jun , Song, Min , Gao, Zhe , Jiang, Ping , Qin, Yue , Li, Hai-Feng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0967-5868 ; E-ISSN: 1532-2653 ; DOI: 10.1016/j.jocn.2017.02.049
Link: http://dx.doi.org/10.1016/j.jocn.2017.02.049
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_jocn_2017_02_049
title: Rs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients
format: Article
creator:
  • Zhang, Xu
  • Ding, Xiao-Jun
  • Wang, Qi
  • Yue, Yao-Xian
  • Xie, Yanchen
  • Hao, Hong-Jun
  • Liang, Bing
  • Zhang, Xian-Jun
  • Song, Min
  • Gao, Zhe
  • Jiang, Ping
  • Qin, Yue
  • Li, Hai-Feng
subjects:
  • Myasthenia Gravis
  • Autoimmune Regulator
  • Polymorphism
  • Susceptibility
  • Severity
  • Myasthenia Gravis
  • Autoimmune Regulator
  • Polymorphism
  • Susceptibility
  • Severity
  • Medicine
ispartof: Journal of Clinical Neuroscience, June 2017, Vol.40, pp.180-184
description: •The first report of AIRE polymorphism in myasthenia gravis (MG).•Significantly higher frequencies of rs3761389G allele in MG group and mild subgroup.•Rs3761389 variant is associated with the susceptibility of MG.•After adjusting for confounders, rs3761389 genotype is not associated with MG severity. Polymorphism in autoimmune regulator (AIRE) gene is associated with various autoimmune disorders. Abnormal AIRE expression is associated with the development of myasthenia gravis (MG). We investigated the association of polymorphism in AIRE gene and the clinical features and severity of MG. The frequencies of alleles and genotypes were compared between 480MG patients and 487 healthy controls, as well as among subgroups of MG patients. The frequencies of rs3761389G allele in MG group (OR=1.213, CI 95% 1.014–1.451, p=0.035) and in mild (Oosterhuis score 0–2) subgroup (OR=1.393, CI 95% 1.110–1.751, p=0.004) were significantly higher than those in the control group....
language: eng
source:
identifier: ISSN: 0967-5868 ; E-ISSN: 1532-2653 ; DOI: 10.1016/j.jocn.2017.02.049
fulltext: fulltext
issn:
  • 0967-5868
  • 09675868
  • 1532-2653
  • 15322653
url: Link


@attributes
ID363524178
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_jocn_2017_02_049
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_jocn_2017_02_049
sourcesystemPC
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
13AABNK
14AAEDT
15AAKOC
16AAOAW
17AAQFI
18AAXLA
19ABBQC
20ABCQJ
21ABMZM
22ABTEW
23ABYKQ
24ACDAQ
25ACRLP
26ADALY
27AEKER
28AEVXI
29AFKWA
30AFTJW
31AFXIZ
32AGHFR
33AGUBO
34AGWIK
35AGYEJ
36AHHHB
37AIKHN
38AITUG
39AJBFU
40AJOXV
41AJRQY
42AJUYK
43AKRLJ
44AMFUW
45ANZVX
46BLXMC
47BNPGV
48EO8
49EO9
50EP2
51EP3
52FDB
53FGOYB
54FIRID
55FNPLU
56G-Q
57GBLVA
58HDW
59HMK
60HMO
61J1W
62KOM
63LCYCR
64MOBAO
65OAUVE
66OP~
67P-8
68P-9
69PC.
70Q38
71R2-
72RPZ
73SAE
74SCC
75SDF
76SDG
77SEL
78SES
79SEW
80SSH
81SSN
82SSZ
83T5K
84Z5R
85~G-
pqid1874784536
galeid519026728
display
typearticle
titleRs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients
creatorZhang, Xu ; Ding, Xiao-Jun ; Wang, Qi ; Yue, Yao-Xian ; Xie, Yanchen ; Hao, Hong-Jun ; Liang, Bing ; Zhang, Xian-Jun ; Song, Min ; Gao, Zhe ; Jiang, Ping ; Qin, Yue ; Li, Hai-Feng
ispartofJournal of Clinical Neuroscience, June 2017, Vol.40, pp.180-184
identifier
subjectMyasthenia Gravis ; Autoimmune Regulator ; Polymorphism ; Susceptibility ; Severity ; Myasthenia Gravis ; Autoimmune Regulator ; Polymorphism ; Susceptibility ; Severity ; Medicine
description•The first report of AIRE polymorphism in myasthenia gravis (MG).•Significantly higher frequencies of rs3761389G allele in MG group and mild subgroup.•Rs3761389 variant is associated with the susceptibility of MG.•After adjusting for confounders, rs3761389 genotype is not associated with MG severity. Polymorphism in autoimmune regulator (AIRE) gene is associated with various autoimmune disorders. Abnormal AIRE expression is associated with the development of myasthenia gravis (MG). We investigated the association of polymorphism in AIRE gene and the clinical features and severity of MG. The frequencies of alleles and genotypes were compared between 480MG patients and 487 healthy controls, as well as among subgroups of MG patients. The frequencies of rs3761389G allele in MG group (OR=1.213, CI 95% 1.014–1.451, p=0.035) and in mild (Oosterhuis score 0–2) subgroup (OR=1.393, CI 95% 1.110–1.751, p=0.004) were significantly higher than those in the control group....
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1016/j.jocn.2017.02.049$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Zhang, Xu
1Ding, Xiao-Jun
2Wang, Qi
3Yue, Yao-Xian
4Xie, Yanchen
5Hao, Hong-Jun
6Liang, Bing
7Zhang, Xian-Jun
8Song, Min
9Gao, Zhe
10Jiang, Ping
11Qin, Yue
12Li, Hai-Feng
titleRs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients
description

•The first report of AIRE polymorphism in myasthenia gravis (MG).•Significantly higher frequencies of rs3761389G allele in MG group and mild subgroup.•Rs3761389 variant is associated with the susceptibility of MG.•After adjusting for confounders, rs3761389 genotype is not associated with MG severity.

Polymorphism in autoimmune regulator (AIRE) gene is associated with various autoimmune disorders. Abnormal AIRE expression is associated with the development of myasthenia gravis (MG). We investigated the association of polymorphism in AIRE gene and the clinical features and severity of MG. The frequencies of alleles and genotypes were compared between 480MG patients and 487 healthy controls, as well as among subgroups of MG patients. The frequencies of rs3761389G allele in MG group (OR=1.213, CI 95% 1.014–1.451, p=0.035) and in mild (Oosterhuis score 0–2) subgroup (OR=1.393, CI 95% 1.110–1.751, p=0.004) were significantly higher than those in the control group....

subject
0Myasthenia Gravis
1Autoimmune Regulator
2Polymorphism
3Susceptibility
4Severity
5Medicine
general
0English
1Elsevier Ltd
210.1016/j.jocn.2017.02.049
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_jocn_2017_02_049
issn
00967-5868
109675868
21532-2653
315322653
rsrctypearticle
creationdate2017
addtitleJournal of Clinical Neuroscience
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
13AABNK
14AAEDT
15AAKOC
16AAOAW
17AAQFI
18AAXLA
19ABBQC
20ABCQJ
21ABMZM
22ABTEW
23ABYKQ
24ACDAQ
25ACRLP
26ADALY
27AEKER
28AEVXI
29AFKWA
30AFTJW
31AFXIZ
32AGHFR
33AGUBO
34AGWIK
35AGYEJ
36AHHHB
37AIKHN
38AITUG
39AJBFU
40AJOXV
41AJRQY
42AJUYK
43AKRLJ
44AMFUW
45ANZVX
46BLXMC
47BNPGV
48EO8
49EO9
50EP2
51EP3
52FDB
53FGOYB
54FIRID
55FNPLU
56G-Q
57GBLVA
58HDW
59HMK
60HMO
61J1W
62KOM
63LCYCR
64MOBAO
65OAUVE
66OP~
67P-8
68P-9
69PC.
70Q38
71R2-
72RPZ
73SAE
74SCC
75SDF
76SDG
77SEL
78SES
79SEW
80SSH
81SSN
82SSZ
83T5K
84Z5R
85~G-
startdate20170601
enddate20170631
lsr40Journal of Clinical Neuroscience, June 2017, Vol.40, pp.180-184
doi10.1016/j.jocn.2017.02.049
citationpf 180 pt 184 vol 40
lsr30VSR-Enriched:[pqid, galeid]
sort
titleRs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients
authorZhang, Xu ; Ding, Xiao-Jun ; Wang, Qi ; Yue, Yao-Xian ; Xie, Yanchen ; Hao, Hong-Jun ; Liang, Bing ; Zhang, Xian-Jun ; Song, Min ; Gao, Zhe ; Jiang, Ping ; Qin, Yue ; Li, Hai-Feng
creationdate20170600
lso0120170600
facets
frbrgroupid6358847093143298541
frbrtype5
newrecords20190904
languageeng
topic
0Myasthenia Gravis
1Autoimmune Regulator
2Polymorphism
3Susceptibility
4Severity
5Medicine
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhang, Xu
1Ding, Xiao-Jun
2Wang, Qi
3Yue, Yao-Xian
4Xie, Yanchen
5Hao, Hong-Jun
6Liang, Bing
7Zhang, Xian-Jun
8Song, Min
9Gao, Zhe
10Jiang, Ping
11Qin, Yue
12Li, Hai-Feng
jtitleJournal of Clinical Neuroscience
creationdate2017
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Zhang
1Ding
2Wang
3Yue
4Xie
5Hao
6Liang
7Song
8Gao
9Jiang
10Qin
11Li
aufirst
0Xu
1Xiao-Jun
2Qi
3Yao-Xian
4Yanchen
5Hong-Jun
6Bing
7Xian-Jun
8Min
9Zhe
10Ping
11Yue
12Hai-Feng
auinitX
auinit1X
au
0Zhang, Xu
1Ding, Xiao-Jun
2Wang, Qi
3Yue, Yao-Xian
4Xie, Yanchen
5Hao, Hong-Jun
6Liang, Bing
7Zhang, Xian-Jun
8Song, Min
9Gao, Zhe
10Jiang, Ping
11Qin, Yue
12Li, Hai-Feng
atitleRs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients
jtitleJournal of Clinical Neuroscience
risdate201706
volume40
spage180
epage184
pages180-184
issn0967-5868
eissn1532-2653
formatjournal
genrearticle
ristypeJOUR
abstract

•The first report of AIRE polymorphism in myasthenia gravis (MG).•Significantly higher frequencies of rs3761389G allele in MG group and mild subgroup.•Rs3761389 variant is associated with the susceptibility of MG.•After adjusting for confounders, rs3761389 genotype is not associated with MG severity.

Polymorphism in autoimmune regulator (AIRE) gene is associated with various autoimmune disorders. Abnormal AIRE expression is associated with the development of myasthenia gravis (MG). We investigated the association of polymorphism in AIRE gene and the clinical features and severity of MG. The frequencies of alleles and genotypes were compared between 480MG patients and 487 healthy controls, as well as among subgroups of MG patients. The frequencies of rs3761389G allele in MG group (OR=1.213, CI 95% 1.014–1.451, p=0.035) and in mild (Oosterhuis score 0–2) subgroup (OR=1.393, CI 95% 1.110–1.751, p=0.004) were significantly higher than those in the control group....

pubElsevier Ltd
doi10.1016/j.jocn.2017.02.049
lad01Journal of Clinical Neuroscience
date2017-06