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Prevalence of Increased Arterial Stiffness in Children with Type 1 Diabetes Mellitus Differs by Measurement Site and Sex: The SEARCH for Diabetes in Youth Study

To discuss vascular stiffness commonly encountered in children with type 1 diabetes mellitus (T1DM). We examined 535 subjects with T1DM (14.6 years; 53% male, 88% non-Hispanic white) and 241 healthy control subjects (17.8 years; 42% male, 39% non-Hispanic white). Abnormalities in brachial distensibi... Full description

Journal Title: The Journal of Pediatrics 2010, Vol.156(5), pp.731-737.e1
Main Author: Urbina, Elaine M
Other Authors: Wadwa, R. Paul , Davis, Cralen , Snively, Beverly M , Dolan, Lawrence M , Daniels, Stephen R , Hamman, Richard F , Dabelea, Dana
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-3476 ; E-ISSN: 1097-6833 ; DOI: 10.1016/j.jpeds.2009.11.011
Link: https://www.sciencedirect.com/science/article/pii/S0022347609011184
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recordid: elsevier_sdoi_10_1016_j_jpeds_2009_11_011
title: Prevalence of Increased Arterial Stiffness in Children with Type 1 Diabetes Mellitus Differs by Measurement Site and Sex: The SEARCH for Diabetes in Youth Study
format: Article
creator:
  • Urbina, Elaine M
  • Wadwa, R. Paul
  • Davis, Cralen
  • Snively, Beverly M
  • Dolan, Lawrence M
  • Daniels, Stephen R
  • Hamman, Richard F
  • Dabelea, Dana
subjects:
  • Medicine
ispartof: The Journal of Pediatrics, 2010, Vol.156(5), pp.731-737.e1
description: To discuss vascular stiffness commonly encountered in children with type 1 diabetes mellitus (T1DM). We examined 535 subjects with T1DM (14.6 years; 53% male, 88% non-Hispanic white) and 241 healthy control subjects (17.8 years; 42% male, 39% non-Hispanic white). Abnormalities in brachial distensibility (BrachD), pulse wave velocity, and augmentation index corrected to a HR of 75 (AIx-75) were examined. Subjects with T1DM had higher body mass index, LDL-cholesterol, fasting glucose, and blood pressure than control subjects. Diabetic subjects had lower BrachD and higher AIx-75 indicating increased stiffness. Age-adjusted pulse wave velocity–trunk (aorto-femoral) was higher in cases (all ≤ < .05). Increased peripheral stiffness was more common than central stiffness in subjects with T1DM (low BrachD in 33% vs high PWV-trunk in 9.9%). Male subjects with type 1 diabetes had a higher prevalence of VS abnormalities than...
language: eng
source:
identifier: ISSN: 0022-3476 ; E-ISSN: 1097-6833 ; DOI: 10.1016/j.jpeds.2009.11.011
fulltext: fulltext
issn:
  • 0022-3476
  • 00223476
  • 1097-6833
  • 10976833
url: Link


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