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Metastasectomy After Targeted Therapy in Patients With Advanced Renal Cell Carcinoma

Metastasectomy is often incorporated in overall treatment in patients with metastatic renal cell carcinoma. While this approach was studied in the immunotherapy era, only a few cases have been described in the targeted therapy era. Thus, we evaluated the role of metastasectomy in patients with metas... Full description

Journal Title: The Journal of Urology 2011, Vol.185(2), pp.439-444
Main Author: Karam, Jose A
Other Authors: Rini, Brian I , Varella, Leticia , Garcia, Jorge A , Dreicer, Robert , Choueiri, Toni K , Jonasch, Eric , Matin, Surena F , Campbell, Steven C , Wood, Christopher G , Tannir, Nizar M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-5347 ; E-ISSN: 1527-3792 ; DOI: 10.1016/j.juro.2010.09.086
Link: https://www.sciencedirect.com/science/article/pii/S0022534710047191
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recordid: elsevier_sdoi_10_1016_j_juro_2010_09_086
title: Metastasectomy After Targeted Therapy in Patients With Advanced Renal Cell Carcinoma
format: Article
creator:
  • Karam, Jose A
  • Rini, Brian I
  • Varella, Leticia
  • Garcia, Jorge A
  • Dreicer, Robert
  • Choueiri, Toni K
  • Jonasch, Eric
  • Matin, Surena F
  • Campbell, Steven C
  • Wood, Christopher G
  • Tannir, Nizar M
subjects:
  • Kidney
  • Carcinoma
  • Renal Cell
  • Neoplasm Metastasis
  • Drug Therapy
  • Reoperation
  • Medicine
ispartof: The Journal of Urology, 2011, Vol.185(2), pp.439-444
description: Metastasectomy is often incorporated in overall treatment in patients with metastatic renal cell carcinoma. While this approach was studied in the immunotherapy era, only a few cases have been described in the targeted therapy era. Thus, we evaluated the role of metastasectomy in patients with metastatic renal cell carcinoma who received prior targeted therapy. We retrospectively evaluated the records of patients who underwent consolidative metastasectomy after targeted therapy at 3 institutions from 2004 to 2009. All patients received at least 1 cycle of targeted therapy before surgical resection of all visible disease. We identified 22 patients. Metastasectomy sites included the retroperitoneum in 12 patients, lung in 6, adrenal gland in 2, bowel in 2, and mediastinum, bone, brain and inferior venal caval thrombus in 1 each. A total of 6 postoperative complications were observed in 4 patients within 12 weeks after surgery, which resolved...
language: eng
source:
identifier: ISSN: 0022-5347 ; E-ISSN: 1527-3792 ; DOI: 10.1016/j.juro.2010.09.086
fulltext: fulltext
issn:
  • 0022-5347
  • 00225347
  • 1527-3792
  • 15273792
url: Link


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titleMetastasectomy After Targeted Therapy in Patients With Advanced Renal Cell Carcinoma
creatorKaram, Jose A ; Rini, Brian I ; Varella, Leticia ; Garcia, Jorge A ; Dreicer, Robert ; Choueiri, Toni K ; Jonasch, Eric ; Matin, Surena F ; Campbell, Steven C ; Wood, Christopher G ; Tannir, Nizar M
ispartofThe Journal of Urology, 2011, Vol.185(2), pp.439-444
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subjectKidney ; Carcinoma ; Renal Cell ; Neoplasm Metastasis ; Drug Therapy ; Reoperation ; Medicine
descriptionMetastasectomy is often incorporated in overall treatment in patients with metastatic renal cell carcinoma. While this approach was studied in the immunotherapy era, only a few cases have been described in the targeted therapy era. Thus, we evaluated the role of metastasectomy in patients with metastatic renal cell carcinoma who received prior targeted therapy. We retrospectively evaluated the records of patients who underwent consolidative metastasectomy after targeted therapy at 3 institutions from 2004 to 2009. All patients received at least 1 cycle of targeted therapy before surgical resection of all visible disease. We identified 22 patients. Metastasectomy sites included the retroperitoneum in 12 patients, lung in 6, adrenal gland in 2, bowel in 2, and mediastinum, bone, brain and inferior venal caval thrombus in 1 each. A total of 6 postoperative complications were observed in 4 patients within 12 weeks after surgery, which resolved...
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titleMetastasectomy After Targeted Therapy in Patients With Advanced Renal Cell Carcinoma
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Metastasectomy is often incorporated in overall treatment in patients with metastatic renal cell carcinoma. While this approach was studied in the immunotherapy era, only a few cases have been described in the targeted therapy era. Thus, we evaluated the role of metastasectomy in patients with metastatic renal cell carcinoma who received prior targeted therapy.

We retrospectively evaluated the records of patients who underwent consolidative metastasectomy after targeted therapy at 3 institutions from 2004 to 2009. All patients received at least 1 cycle of targeted therapy before surgical resection of all visible disease.

We identified 22 patients. Metastasectomy sites included the retroperitoneum in 12 patients, lung in 6, adrenal gland in 2, bowel in 2, and mediastinum, bone, brain and inferior venal caval thrombus in 1 each. A total of 6 postoperative complications were observed in 4 patients within 12 weeks after surgery, which resolved...

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abstract

Metastasectomy is often incorporated in overall treatment in patients with metastatic renal cell carcinoma. While this approach was studied in the immunotherapy era, only a few cases have been described in the targeted therapy era. Thus, we evaluated the role of metastasectomy in patients with metastatic renal cell carcinoma who received prior targeted therapy.

We retrospectively evaluated the records of patients who underwent consolidative metastasectomy after targeted therapy at 3 institutions from 2004 to 2009. All patients received at least 1 cycle of targeted therapy before surgical resection of all visible disease.

We identified 22 patients. Metastasectomy sites included the retroperitoneum in 12 patients, lung in 6, adrenal gland in 2, bowel in 2, and mediastinum, bone, brain and inferior venal caval thrombus in 1 each. A total of 6 postoperative complications were observed in 4 patients within 12 weeks after surgery, which resolved...

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