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DNA methylation yields epigenetic clues into the diabetic nephropathy of Pima Indians

Environmental factors drive epigenetic programming. DNA methylation is the best studied modification transmitting epigenetic information. A study by Qiu et al. examined potential epigenetic roots for the decline of renal function in Pima Indians. A genomewide survey of blood leukocytes uncovered dif... Full description

Journal Title: Kidney International June 2018, Vol.93(6), pp.1272-1275
Main Author: Bomsztyk, Karol
Other Authors: Denisenko, Oleg , Wang, Yuliang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0085-2538 ; E-ISSN: 1523-1755 ; DOI: 10.1016/j.kint.2018.02.015
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recordid: elsevier_sdoi_10_1016_j_kint_2018_02_015
title: DNA methylation yields epigenetic clues into the diabetic nephropathy of Pima Indians
format: Article
creator:
  • Bomsztyk, Karol
  • Denisenko, Oleg
  • Wang, Yuliang
subjects:
  • Medicine
ispartof: Kidney International, June 2018, Vol.93(6), pp.1272-1275
description: Environmental factors drive epigenetic programming. DNA methylation is the best studied modification transmitting epigenetic information. A study by Qiu et al. examined potential epigenetic roots for the decline of renal function in Pima Indians. A genomewide survey of blood leukocytes uncovered differentially methylated DNA sites in regulatory regions of genes associated with chronic kidney disease. This longitudinal study provides the first clues on epigenetic links between environmental factors and a high prevalence of diabetic kidney disease in Pima Indians.
language: eng
source:
identifier: ISSN: 0085-2538 ; E-ISSN: 1523-1755 ; DOI: 10.1016/j.kint.2018.02.015
fulltext: no_fulltext
issn:
  • 0085-2538
  • 00852538
  • 1523-1755
  • 15231755
url: Link


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descriptionEnvironmental factors drive epigenetic programming. DNA methylation is the best studied modification transmitting epigenetic information. A study by Qiu et al. examined potential epigenetic roots for the decline of renal function in Pima Indians. A genomewide survey of blood leukocytes uncovered differentially methylated DNA sites in regulatory regions of genes associated with chronic kidney disease. This longitudinal study provides the first clues on epigenetic links between environmental factors and a high prevalence of diabetic kidney disease in Pima Indians.
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