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Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury

To evaluate the effects of hyperbaric oxygen (HBO) therapy on MMP-2 and MMP-9 expression and spinal cord edema after acute spinal cord injury (SCI). Ninety-six healthy adult Sprague − Dawley rats were randomly divided into 4 groups: sham, sham + HBO, SCI, and SCI + HBO. Each group was subdivided int... Full description

Journal Title: Life Sciences 18 December 2013, Vol.93(25-26), pp.1033-1038
Main Author: Yang, Jing
Other Authors: Wang, Guozhong , Gao, Chunjin , Shao, Guiqiang , Kang, Nan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0024-3205 ; E-ISSN: 1879-0631 ; DOI: 10.1016/j.lfs.2013.10.015
Link: https://www.sciencedirect.com/science/article/pii/S0024320513006176
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recordid: elsevier_sdoi_10_1016_j_lfs_2013_10_015
title: Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury
format: Article
creator:
  • Yang, Jing
  • Wang, Guozhong
  • Gao, Chunjin
  • Shao, Guiqiang
  • Kang, Nan
subjects:
  • Hyperbaric Oxygen
  • Spinal Cord Injury
  • Mmp-2
  • Mmp-9
  • Sciences (General)
  • Biology
ispartof: Life Sciences, 18 December 2013, Vol.93(25-26), pp.1033-1038
description: To evaluate the effects of hyperbaric oxygen (HBO) therapy on MMP-2 and MMP-9 expression and spinal cord edema after acute spinal cord injury (SCI). Ninety-six healthy adult Sprague − Dawley rats were randomly divided into 4 groups: sham, sham + HBO, SCI, and SCI + HBO. Each group was subdivided into 4 subgroups of 6 rats each: 24 h, 48 h, 72 h, and 5 d post-injury. The expression levels of matrix metalloproteinase-2 (MMP-2), MMP-9, interleukin (IL-6), and vascular endothelial growth factor (VEGF) were measured using ELISA. The water content of the spinal cord was also measured by Elliot equation. MMP-2 and MMP-9 levels and spinal cord water content increased significantly in the SCI group compared to those in the sham and sham + HBO...
language: eng
source:
identifier: ISSN: 0024-3205 ; E-ISSN: 1879-0631 ; DOI: 10.1016/j.lfs.2013.10.015
fulltext: fulltext
issn:
  • 0024-3205
  • 00243205
  • 1879-0631
  • 18790631
url: Link


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titleEffects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury
creatorYang, Jing ; Wang, Guozhong ; Gao, Chunjin ; Shao, Guiqiang ; Kang, Nan
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subjectHyperbaric Oxygen ; Spinal Cord Injury ; Mmp-2 ; Mmp-9 ; Sciences (General) ; Biology
descriptionTo evaluate the effects of hyperbaric oxygen (HBO) therapy on MMP-2 and MMP-9 expression and spinal cord edema after acute spinal cord injury (SCI). Ninety-six healthy adult Sprague − Dawley rats were randomly divided into 4 groups: sham, sham + HBO, SCI, and SCI + HBO. Each group was subdivided into 4 subgroups of 6 rats each: 24 h, 48 h, 72 h, and 5 d post-injury. The expression levels of matrix metalloproteinase-2 (MMP-2), MMP-9, interleukin (IL-6), and vascular endothelial growth factor (VEGF) were measured using ELISA. The water content of the spinal cord was also measured by Elliot equation. MMP-2 and MMP-9 levels and spinal cord water content increased significantly in the SCI group compared to those in the sham and sham + HBO...
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