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Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir

Fragile histidine triad ( ) gene located at chromosome 3p14.2 is a putative tumor suppressor gene involved in the pathogenesis of breast cancer. Both genetic and epigenetic alterations in have been implicated in breast carcinoma. In the present study, our main aim was to study the impact of these tw... Full description

Journal Title: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2011, Vol.707(1), pp.1-8
Main Author: Syeed, Nidda
Other Authors: Husain, Syed Akhtar , Sameer, A. Syed , Chowdhri, Nissar A , Siddiqi, Mushtaq A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-5107 ; E-ISSN: 1873-135X ; DOI: 10.1016/j.mrfmmm.2010.11.001
Link: https://www.sciencedirect.com/science/article/pii/S0027510710003039
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recordid: elsevier_sdoi_10_1016_j_mrfmmm_2010_11_001
title: Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir
format: Article
creator:
  • Syeed, Nidda
  • Husain, Syed Akhtar
  • Sameer, A. Syed
  • Chowdhri, Nissar A
  • Siddiqi, Mushtaq A
subjects:
  • Fhit
  • Breast Cancer
  • Kashmir
  • Mutation
  • Hypermethylation
  • Biology
  • Chemistry
ispartof: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2011, Vol.707(1), pp.1-8
description: Fragile histidine triad ( ) gene located at chromosome 3p14.2 is a putative tumor suppressor gene involved in the pathogenesis of breast cancer. Both genetic and epigenetic alterations in have been implicated in breast carcinoma. In the present study, our main aim was to study the impact of these two kinds of alterations of gene in breast cancer patients of Kashmir. We screened a total of 130 breast cancer patients of Kashmir by PCR-SSCP followed by direct sequencing and methylation specific PCR. Mutational screening of gene revealed significant amount of mutations [40.7% (53/130)] in five hot spot exons (exon 5–9), promoter was found to be hypermethylated in 59 of 130 [45.3%] breast cancer patients in our population. In the present study we have shown a significant association between the mutational...
language: eng
source:
identifier: ISSN: 0027-5107 ; E-ISSN: 1873-135X ; DOI: 10.1016/j.mrfmmm.2010.11.001
fulltext: fulltext
issn:
  • 0027-5107
  • 00275107
  • 1873-135X
  • 1873135X
url: Link


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titleMutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir
creatorSyeed, Nidda ; Husain, Syed Akhtar ; Sameer, A. Syed ; Chowdhri, Nissar A ; Siddiqi, Mushtaq A
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subjectFhit ; Breast Cancer ; Kashmir ; Mutation ; Hypermethylation ; Biology ; Chemistry
descriptionFragile histidine triad ( ) gene located at chromosome 3p14.2 is a putative tumor suppressor gene involved in the pathogenesis of breast cancer. Both genetic and epigenetic alterations in have been implicated in breast carcinoma. In the present study, our main aim was to study the impact of these two kinds of alterations of gene in breast cancer patients of Kashmir. We screened a total of 130 breast cancer patients of Kashmir by PCR-SSCP followed by direct sequencing and methylation specific PCR. Mutational screening of gene revealed significant amount of mutations [40.7% (53/130)] in five hot spot exons (exon 5–9), promoter was found to be hypermethylated in 59 of 130 [45.3%] breast cancer patients in our population. In the present study we have shown a significant association between the mutational...
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