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Construction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy

Novel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used t... Full description

Journal Title: Nanomedicine December 2011, Vol.7(6), pp.945-954
Main Author: Wu, Yan
Other Authors: Jiao, Fang , Han, Siyuan , Fan, Tengfei , Liu, Ying , Li, Wei , Hu, Liming , Zhao, Yuliang , Chen, Chunying
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1549-9634 ; E-ISSN: 1549-9642 ; DOI: 10.1016/j.nano.2011.04.010
Link: http://dx.doi.org/10.1016/j.nano.2011.04.010
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recordid: elsevier_sdoi_10_1016_j_nano_2011_04_010
title: Construction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy
format: Article
creator:
  • Wu, Yan
  • Jiao, Fang
  • Han, Siyuan
  • Fan, Tengfei
  • Liu, Ying
  • Li, Wei
  • Hu, Liming
  • Zhao, Yuliang
  • Chen, Chunying
subjects:
  • Drug Delivery
  • Controlled Drug Release
  • Hyperbranched Copolymer
  • Anti-Tumor Activity
  • Biocompatibility
  • Drug Delivery
  • Controlled Drug Release
  • Hyperbranched Copolymer
  • Anti-Tumor Activity
  • Biocompatibility
  • Medicine
ispartof: Nanomedicine, December 2011, Vol.7(6), pp.945-954
description: Novel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery...
language: eng
source:
identifier: ISSN: 1549-9634 ; E-ISSN: 1549-9642 ; DOI: 10.1016/j.nano.2011.04.010
fulltext: fulltext
issn:
  • 1549-9634
  • 15499634
  • 1549-9642
  • 15499642
url: Link


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titleConstruction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy
creatorWu, Yan ; Jiao, Fang ; Han, Siyuan ; Fan, Tengfei ; Liu, Ying ; Li, Wei ; Hu, Liming ; Zhao, Yuliang ; Chen, Chunying
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subjectDrug Delivery ; Controlled Drug Release ; Hyperbranched Copolymer ; Anti-Tumor Activity ; Biocompatibility ; Drug Delivery ; Controlled Drug Release ; Hyperbranched Copolymer ; Anti-Tumor Activity ; Biocompatibility ; Medicine
descriptionNovel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery...
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Novel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery...

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Novel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery...

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lad01Nanomedicine
date2011-12