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A practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats

► The bacteria injected rats displayed mechanical allodynia, thermal hyperalgesia. ► The osteomyelitis induced pain behavior can be reversed by Celecoxib. ► Hypertrophy of both microglia and astrocytes in spinal cord was observed. Osteomyelitis is an acute or chronic inflammatory process of bone acc... Full description

Journal Title: Neuroscience Letters 04 April 2012, Vol.513(2), pp.198-203
Main Author: Yang, Chang-Jiang
Other Authors: Li, Qian , Wu, Gen-Cheng , Wang, Yan-Qing , Mao-Ying, Qi-Liang
Format: Electronic Article Electronic Article
Language: English
Subjects:
Rat
Rat
ID: ISSN: 0304-3940 ; E-ISSN: 1872-7972 ; DOI: 10.1016/j.neulet.2012.02.038
Link: http://dx.doi.org/10.1016/j.neulet.2012.02.038
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recordid: elsevier_sdoi_10_1016_j_neulet_2012_02_038
title: A practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats
format: Article
creator:
  • Yang, Chang-Jiang
  • Li, Qian
  • Wu, Gen-Cheng
  • Wang, Yan-Qing
  • Mao-Ying, Qi-Liang
subjects:
  • Osteomyelitis
  • Pain
  • Staphylococcus Aureus
  • Mechanical Allodynia
  • Rat
  • Osteomyelitis
  • Pain
  • Staphylococcus Aureus
  • Mechanical Allodynia
  • Rat
  • Medicine
  • Anatomy & Physiology
ispartof: Neuroscience Letters, 04 April 2012, Vol.513(2), pp.198-203
description: ► The bacteria injected rats displayed mechanical allodynia, thermal hyperalgesia. ► The osteomyelitis induced pain behavior can be reversed by Celecoxib. ► Hypertrophy of both microglia and astrocytes in spinal cord was observed. Osteomyelitis is an acute or chronic inflammatory process of bone accompanied with mild to severe pain. Generally, mild to moderate pain induced by osteomyelitis can be relieved, yet severe pain cannot. Therefore, a further investigation into the mechanism of severe pain induced by osteomyelitis is needed. In this study, a traditional rat model of osteomyelitis was induced by intra-tibial injection of Staphylococcus aureus. Then, a series of tests including bone histology, blood analysis, mechanical allodynia, thermal hyperalgesia, and immunohistochemistry were performed. Four days after an intra-tibial bacterial injection, acute inflammation was observed in the bone marrow, which developed into chronic inflammation 12 days after the...
language: eng
source:
identifier: ISSN: 0304-3940 ; E-ISSN: 1872-7972 ; DOI: 10.1016/j.neulet.2012.02.038
fulltext: fulltext
issn:
  • 0304-3940
  • 03043940
  • 1872-7972
  • 18727972
url: Link


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titleA practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats
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ispartofNeuroscience Letters, 04 April 2012, Vol.513(2), pp.198-203
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subjectOsteomyelitis ; Pain ; Staphylococcus Aureus ; Mechanical Allodynia ; Rat ; Osteomyelitis ; Pain ; Staphylococcus Aureus ; Mechanical Allodynia ; Rat ; Medicine ; Anatomy & Physiology
description► The bacteria injected rats displayed mechanical allodynia, thermal hyperalgesia. ► The osteomyelitis induced pain behavior can be reversed by Celecoxib. ► Hypertrophy of both microglia and astrocytes in spinal cord was observed. Osteomyelitis is an acute or chronic inflammatory process of bone accompanied with mild to severe pain. Generally, mild to moderate pain induced by osteomyelitis can be relieved, yet severe pain cannot. Therefore, a further investigation into the mechanism of severe pain induced by osteomyelitis is needed. In this study, a traditional rat model of osteomyelitis was induced by intra-tibial injection of Staphylococcus aureus. Then, a series of tests including bone histology, blood analysis, mechanical allodynia, thermal hyperalgesia, and immunohistochemistry were performed. Four days after an intra-tibial bacterial injection, acute inflammation was observed in the bone marrow, which developed into chronic inflammation 12 days after the...
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titleA practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats
description

► The bacteria injected rats displayed mechanical allodynia, thermal hyperalgesia. ► The osteomyelitis induced pain behavior can be reversed by Celecoxib. ► Hypertrophy of both microglia and astrocytes in spinal cord was observed.

Osteomyelitis is an acute or chronic inflammatory process of bone accompanied with mild to severe pain. Generally, mild to moderate pain induced by osteomyelitis can be relieved, yet severe pain cannot. Therefore, a further investigation into the mechanism of severe pain induced by osteomyelitis is needed. In this study, a traditional rat model of osteomyelitis was induced by intra-tibial injection of Staphylococcus aureus. Then, a series of tests including bone histology, blood analysis, mechanical allodynia, thermal hyperalgesia, and immunohistochemistry were performed. Four days after an intra-tibial bacterial injection, acute inflammation was observed in the bone marrow, which developed into chronic inflammation 12 days after the...

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abstract

► The bacteria injected rats displayed mechanical allodynia, thermal hyperalgesia. ► The osteomyelitis induced pain behavior can be reversed by Celecoxib. ► Hypertrophy of both microglia and astrocytes in spinal cord was observed.

Osteomyelitis is an acute or chronic inflammatory process of bone accompanied with mild to severe pain. Generally, mild to moderate pain induced by osteomyelitis can be relieved, yet severe pain cannot. Therefore, a further investigation into the mechanism of severe pain induced by osteomyelitis is needed. In this study, a traditional rat model of osteomyelitis was induced by intra-tibial injection of Staphylococcus aureus. Then, a series of tests including bone histology, blood analysis, mechanical allodynia, thermal hyperalgesia, and immunohistochemistry were performed. Four days after an intra-tibial bacterial injection, acute inflammation was observed in the bone marrow, which developed into chronic inflammation 12 days after the...

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lad01Neuroscience Letters
date2012-04-04