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Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy

The rhesus monkey is a useful model for examining age-related effects on the brain, because of the extensive neuroanatomical homology between the monkey and the human brain, the tight control for neurological diseases as well as the possibility of obtaining relevant behavioral data and post-mortem t... Full description

Journal Title: Neurobiology of Aging 2011, Vol.32(6), pp.1138-1148
Main Author: Ronen, Itamar
Other Authors: Fan, Xiaoying , Schettler, Steve , Jain, Sahil , Murray, Donna , Kim, Dae-Shik , Killiany, Ronald , Rosene, Douglas
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0197-4580 ; E-ISSN: 1558-1497 ; DOI: 10.1016/j.neurobiolaging.2009.05.020
Link: http://dx.doi.org/10.1016/j.neurobiolaging.2009.05.020
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recordid: elsevier_sdoi_10_1016_j_neurobiolaging_2009_05_020
title: Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy
format: Article
creator:
  • Ronen, Itamar
  • Fan, Xiaoying
  • Schettler, Steve
  • Jain, Sahil
  • Murray, Donna
  • Kim, Dae-Shik
  • Killiany, Ronald
  • Rosene, Douglas
subjects:
  • Magnetic Resonance Spectroscopy
  • Aging Brain
  • Rhesus Monkey
  • Brain Metabolites
  • Magnetic Resonance Spectroscopy
  • Aging Brain
  • Rhesus Monkey
  • Brain Metabolites
  • Anatomy & Physiology
ispartof: Neurobiology of Aging, 2011, Vol.32(6), pp.1138-1148
description: The rhesus monkey is a useful model for examining age-related effects on the brain, because of the extensive neuroanatomical homology between the monkey and the human brain, the tight control for neurological diseases as well as the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. Here, proton magnetic resonance spectroscopy ( 1H-MRS) was used together with high-resolution anatomical MRI images to carefully assess regional concentrations of brain metabolites in a group of 20 rhesus monkeys. In an anterior volume of interest (VOI) that covered frontal and prefrontal areas, significant positive correlations of myo-inositol and of total creatine concentrations with age were detected, whereas N-acetyl aspartate (NAA) and choline compounds (Cho) were not significantly correlated with age. In an occipito-parietal VOI, all metabolites showed no statistically significant age-dependent trend....
language: eng
source:
identifier: ISSN: 0197-4580 ; E-ISSN: 1558-1497 ; DOI: 10.1016/j.neurobiolaging.2009.05.020
fulltext: fulltext
issn:
  • 0197-4580
  • 01974580
  • 1558-1497
  • 15581497
url: Link


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titleRegional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy
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descriptionThe rhesus monkey is a useful model for examining age-related effects on the brain, because of the extensive neuroanatomical homology between the monkey and the human brain, the tight control for neurological diseases as well as the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. Here, proton magnetic resonance spectroscopy ( 1H-MRS) was used together with high-resolution anatomical MRI images to carefully assess regional concentrations of brain metabolites in a group of 20 rhesus monkeys. In an anterior volume of interest (VOI) that covered frontal and prefrontal areas, significant positive correlations of myo-inositol and of total creatine concentrations with age were detected, whereas N-acetyl aspartate (NAA) and choline compounds (Cho) were not significantly correlated with age. In an occipito-parietal VOI, all metabolites showed no statistically significant age-dependent trend....
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