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Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2011.03.079 Byline: Brandon Abbs, Lichen Liang, Nikos Makris, Ming Tsuang, Larry J. Seidman, Jill M. Goldstein Keywords: Verbal memory; Sex differences; Schizophrenia; Magnetic resonance imaging; Br... Full description

Journal Title: NeuroImage 15 June 2011, Vol.56(4), pp.1865-1874
Main Author: Abbs, Brandon
Other Authors: Liang, Lichen , Makris, Nikos , Tsuang, Ming , Seidman, Larry J , Goldstein, Jill M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1053-8119 ; E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2011.03.079
Link: https://www.sciencedirect.com/science/article/pii/S1053811911003739
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recordid: elsevier_sdoi_10_1016_j_neuroimage_2011_03_079
title: Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical
format: Article
creator:
  • Abbs, Brandon
  • Liang, Lichen
  • Makris, Nikos
  • Tsuang, Ming
  • Seidman, Larry J
  • Goldstein, Jill M
subjects:
  • Verbal Memory
  • Sex Differences
  • Schizophrenia
  • Magnetic Resonance Imaging
  • Brain Morphometry
  • Covariance
  • Medicine
ispartof: NeuroImage, 15 June 2011, Vol.56(4), pp.1865-1874
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2011.03.079 Byline: Brandon Abbs, Lichen Liang, Nikos Makris, Ming Tsuang, Larry J. Seidman, Jill M. Goldstein Keywords: Verbal memory; Sex differences; Schizophrenia; Magnetic resonance imaging; Brain morphometry; Covariance Abstract: Women have consistently demonstrated better verbal memory on tests that evaluate immediate and delayed free recall. In patients with schizophrenia, these verbal memory processes are relatively more preserved in women than men. However an understanding of the brain anatomy of the female advantage for verbal memory is still unclear. 29 females and 59 males with schizophrenia made comparable to 21 female and 27 male healthy volunteers were scanned using structural magnetic resonance imaging (sMRI) in order to assess volumes of regions across the entire brain. Sex differences within and between groups in the covariance structure of memory circuitry regions were evaluated using a novel approach to covariance analysis (the Box M Test). Brain areas of interest included the prefrontal cortex (PFC), inferior parietal lobule (iPAR), anterior cingulate gyrus (ACG), parahippocampus, and hippocampus (HIPP). Results showed significant differences in the covariance matrices of females and males with schizophrenia compared with their healthy counterparts, in particular the relationships between iPAR-PFC, iPAR-ACG, and HIPP-PFC. Sex differences in the iPAR-PFC relationship were significantly associated with sex differences in verbal memory performance. In control women, but not in men ACG volume correlated strongly with memory performance. In schizophrenia, ACG volume was reduced in females, but not in men, relative to controls. Findings suggest that the relationship between iPAR and PFC is particularly important for understanding the relative preservation of verbal memory processing in females with schizophrenia and may compensate for ACG volume reductions. These results illustrate the utility of a unique covariance structure modeling approach that yields important new knowledge for understanding the nature of schizophrenia. Article History: Received 11 January 2011; Revised 23 March 2011; Accepted 29 March 2011
language: eng
source:
identifier: ISSN: 1053-8119 ; E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2011.03.079
fulltext: fulltext
issn:
  • 1053-8119
  • 10538119
  • 1095-9572
  • 10959572
url: Link


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titleCovariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical
creatorAbbs, Brandon ; Liang, Lichen ; Makris, Nikos ; Tsuang, Ming ; Seidman, Larry J ; Goldstein, Jill M
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neuroimage.2011.03.079 Byline: Brandon Abbs, Lichen Liang, Nikos Makris, Ming Tsuang, Larry J. Seidman, Jill M. Goldstein Keywords: Verbal memory; Sex differences; Schizophrenia; Magnetic resonance imaging; Brain morphometry; Covariance Abstract: Women have consistently demonstrated better verbal memory on tests that evaluate immediate and delayed free recall. In patients with schizophrenia, these verbal memory processes are relatively more preserved in women than men. However an understanding of the brain anatomy of the female advantage for verbal memory is still unclear. 29 females and 59 males with schizophrenia made comparable to 21 female and 27 male healthy volunteers were scanned using structural magnetic resonance imaging (sMRI) in order to assess volumes of regions across the entire brain. Sex differences within and between groups in the covariance structure of memory circuitry regions were evaluated using a novel approach to covariance analysis (the Box M Test). Brain areas of interest included the prefrontal cortex (PFC), inferior parietal lobule (iPAR), anterior cingulate gyrus (ACG), parahippocampus, and hippocampus (HIPP). Results showed significant differences in the covariance matrices of females and males with schizophrenia compared with their healthy counterparts, in particular the relationships between iPAR-PFC, iPAR-ACG, and HIPP-PFC. Sex differences in the iPAR-PFC relationship were significantly associated with sex differences in verbal memory performance. In control women, but not in men ACG volume correlated strongly with memory performance. In schizophrenia, ACG volume was reduced in females, but not in men, relative to controls. Findings suggest that the relationship between iPAR and PFC is particularly important for understanding the relative preservation of verbal memory processing in females with schizophrenia and may compensate for ACG volume reductions. These results illustrate the utility of a unique covariance structure modeling approach that yields important new knowledge for understanding the nature of schizophrenia. Article History: Received 11 January 2011; Revised 23 March 2011; Accepted 29 March 2011
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Women have consistently demonstrated better verbal memory on tests that evaluate immediate and delayed free recall. In patients with schizophrenia, these verbal memory processes are relatively more preserved in women than men. However an understanding of the brain anatomy of the female advantage for verbal memory is still unclear.

29 females and 59 males with schizophrenia made comparable to 21 female and 27 male healthy volunteers were scanned using structural magnetic resonance imaging (sMRI) in order to assess volumes of regions across the entire brain. Sex differences within and between groups in the covariance structure of memory circuitry regions were evaluated using a novel approach to covariance analysis (the Box M Test). Brain areas of interest included the prefrontal cortex (PFC), inferior parietal lobule (iPAR), anterior cingulate gyrus (ACG), parahippocampus, and hippocampus (HIPP).

Results showed significant differences in the...

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Women have consistently demonstrated better verbal memory on tests that evaluate immediate and delayed free recall. In patients with schizophrenia, these verbal memory processes are relatively more preserved in women than men. However an understanding of the brain anatomy of the female advantage for verbal memory is still unclear.

29 females and 59 males with schizophrenia made comparable to 21 female and 27 male healthy volunteers were scanned using structural magnetic resonance imaging (sMRI) in order to assess volumes of regions across the entire brain. Sex differences within and between groups in the covariance structure of memory circuitry regions were evaluated using a novel approach to covariance analysis (the Box M Test). Brain areas of interest included the prefrontal cortex (PFC), inferior parietal lobule (iPAR), anterior cingulate gyrus (ACG), parahippocampus, and hippocampus (HIPP).

Results showed significant differences in the...

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