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Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice

Many brain diseases have been linked to abnormal oxygen metabolism and blood perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging cerebral metabolic rate of oxygen (CMRO ) and cerebral blood flow (CBF), as well as the oxygen extraction fraction (OEF) that re... Full description

Journal Title: NeuroImage 01 January 2013, Vol.64, pp.437-447
Main Author: Zhu, Xiao-Hong
Other Authors: Chen, James M , Tu, Tsang-Wei , Chen, Wei , Song, Sheng-Kwei
Format: Electronic Article Electronic Article
Language: English
Subjects:
Cbf
Oef
ID: ISSN: 1053-8119 ; E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.09.028
Link: https://www.sciencedirect.com/science/article/pii/S105381191200938X
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title: Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice
format: Article
creator:
  • Zhu, Xiao-Hong
  • Chen, James M
  • Tu, Tsang-Wei
  • Chen, Wei
  • Song, Sheng-Kwei
subjects:
  • In Vivo 17o Mrs Imaging
  • Cmro2
  • Cbf
  • Oef
  • Stroke
  • Medicine
ispartof: NeuroImage, 01 January 2013, Vol.64, pp.437-447
description: Many brain diseases have been linked to abnormal oxygen metabolism and blood perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging cerebral metabolic rate of oxygen (CMRO ) and cerebral blood flow (CBF), as well as the oxygen extraction fraction (OEF) that reflects the balance between CMRO and CBF. This study employed the recently developed in vivo O MR spectroscopic imaging to simultaneously assess CMRO , CBF and OEF in the brain using a preclinical middle cerebral arterial occlusion mouse model with a brief inhalation of O-labeled oxygen gas. The results demonstrated high sensitivity and reliability of the noninvasive O-MR approach for rapidly imaging CMRO , CBF and OEF abnormalities in the ischemic cortex of the MCAO mouse brain. It was found that in the ischemic brain regions both CMRO ...
language: eng
source:
identifier: ISSN: 1053-8119 ; E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2012.09.028
fulltext: fulltext
issn:
  • 1053-8119
  • 10538119
  • 1095-9572
  • 10959572
url: Link


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subjectIn Vivo 17o Mrs Imaging ; Cmro2 ; Cbf ; Oef ; Stroke ; Medicine
descriptionMany brain diseases have been linked to abnormal oxygen metabolism and blood perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging cerebral metabolic rate of oxygen (CMRO ) and cerebral blood flow (CBF), as well as the oxygen extraction fraction (OEF) that reflects the balance between CMRO and CBF. This study employed the recently developed in vivo O MR spectroscopic imaging to simultaneously assess CMRO , CBF and OEF in the brain using a preclinical middle cerebral arterial occlusion mouse model with a brief inhalation of O-labeled oxygen gas. The results demonstrated high sensitivity and reliability of the noninvasive O-MR approach for rapidly imaging CMRO , CBF and OEF abnormalities in the ischemic cortex of the MCAO mouse brain. It was found that in the ischemic brain regions both CMRO ...
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