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An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats

Glial glutamate transporter-1 (GLT-1) plays an essential role in the maintenance of glutamate homeostasis and is involved in the development and maintenance of pathological pain. The present study was undertaken (1) to observe the anti-nociceptive effects of ceftriaxone (Cef) in a chronic neuropathi... Full description

Journal Title: Pain 2010, Vol.148(2), pp.284-301
Main Author: Hu, Yuyan
Other Authors: Li, Wenbin , Lu, Lili , Cai, Jinsong , Xian, Xiaohui , Zhang, Min , Li, Qingjun , Li, Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
Rat
Rat
ID: ISSN: 0304-3959 ; E-ISSN: 1872-6623 ; DOI: 10.1016/j.pain.2009.11.014
Link: http://dx.doi.org/10.1016/j.pain.2009.11.014
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recordid: elsevier_sdoi_10_1016_j_pain_2009_11_014
title: An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats
format: Article
creator:
  • Hu, Yuyan
  • Li, Wenbin
  • Lu, Lili
  • Cai, Jinsong
  • Xian, Xiaohui
  • Zhang, Min
  • Li, Qingjun
  • Li, Li
subjects:
  • Ceftriaxone
  • Glt-1
  • Neuropathic Pain
  • Chronic Constrictive Nerve Injury
  • Spinal Cord
  • Rat
  • Ceftriaxone
  • Glt-1
  • Neuropathic Pain
  • Chronic Constrictive Nerve Injury
  • Spinal Cord
  • Rat
  • Medicine
ispartof: Pain, 2010, Vol.148(2), pp.284-301
description: Glial glutamate transporter-1 (GLT-1) plays an essential role in the maintenance of glutamate homeostasis and is involved in the development and maintenance of pathological pain. The present study was undertaken (1) to observe the anti-nociceptive effects of ceftriaxone (Cef) in a chronic neuropathic pain model induced by chronic constrictive nerve injury (CCI) of the sciatic nerve and (2) to identify the role of spinal GLT-1 in the process. CCI induced significant thermal hyperalgesia and mechanical allodynia, which began from postoperative day 3 and lasted to day 21. This long-term hyperalgesia was accompanied by significant down-regulation of GLT-1 expression in the L4–L6 segments of the spinal dorsal horn, as revealed by immunohistochemistry and Western blot. Intraperitoneal preventive and therapeutic administration of Cef effectively prevented or reversed, respectively, the development of thermal hyperalgesia, mechanical allodynia, and GLT-1 down-regulation in the spinal...
language: eng
source:
identifier: ISSN: 0304-3959 ; E-ISSN: 1872-6623 ; DOI: 10.1016/j.pain.2009.11.014
fulltext: fulltext
issn:
  • 0304-3959
  • 03043959
  • 1872-6623
  • 18726623
url: Link


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titleAn anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats
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subjectCeftriaxone ; Glt-1 ; Neuropathic Pain ; Chronic Constrictive Nerve Injury ; Spinal Cord ; Rat ; Ceftriaxone ; Glt-1 ; Neuropathic Pain ; Chronic Constrictive Nerve Injury ; Spinal Cord ; Rat ; Medicine
descriptionGlial glutamate transporter-1 (GLT-1) plays an essential role in the maintenance of glutamate homeostasis and is involved in the development and maintenance of pathological pain. The present study was undertaken (1) to observe the anti-nociceptive effects of ceftriaxone (Cef) in a chronic neuropathic pain model induced by chronic constrictive nerve injury (CCI) of the sciatic nerve and (2) to identify the role of spinal GLT-1 in the process. CCI induced significant thermal hyperalgesia and mechanical allodynia, which began from postoperative day 3 and lasted to day 21. This long-term hyperalgesia was accompanied by significant down-regulation of GLT-1 expression in the L4–L6 segments of the spinal dorsal horn, as revealed by immunohistochemistry and Western blot. Intraperitoneal preventive and therapeutic administration of Cef effectively prevented or reversed, respectively, the development of thermal hyperalgesia, mechanical allodynia, and GLT-1 down-regulation in the spinal...
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titleAn anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats
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Glial glutamate transporter-1 (GLT-1) plays an essential role in the maintenance of glutamate homeostasis and is involved in the development and maintenance of pathological pain. The present study was undertaken (1) to observe the anti-nociceptive effects of ceftriaxone (Cef) in a chronic neuropathic pain model induced by chronic constrictive nerve injury (CCI) of the sciatic nerve and (2) to identify the role of spinal GLT-1 in the process. CCI induced significant thermal hyperalgesia and mechanical allodynia, which began from postoperative day 3 and lasted to day 21. This long-term hyperalgesia was accompanied by significant down-regulation of GLT-1 expression in the L4–L6 segments of the spinal dorsal horn, as revealed by immunohistochemistry and Western blot. Intraperitoneal preventive and therapeutic administration of Cef effectively prevented or reversed, respectively, the development of thermal hyperalgesia, mechanical allodynia, and GLT-1 down-regulation in the spinal...

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Glial glutamate transporter-1 (GLT-1) plays an essential role in the maintenance of glutamate homeostasis and is involved in the development and maintenance of pathological pain. The present study was undertaken (1) to observe the anti-nociceptive effects of ceftriaxone (Cef) in a chronic neuropathic pain model induced by chronic constrictive nerve injury (CCI) of the sciatic nerve and (2) to identify the role of spinal GLT-1 in the process. CCI induced significant thermal hyperalgesia and mechanical allodynia, which began from postoperative day 3 and lasted to day 21. This long-term hyperalgesia was accompanied by significant down-regulation of GLT-1 expression in the L4–L6 segments of the spinal dorsal horn, as revealed by immunohistochemistry and Western blot. Intraperitoneal preventive and therapeutic administration of Cef effectively prevented or reversed, respectively, the development of thermal hyperalgesia, mechanical allodynia, and GLT-1 down-regulation in the spinal...

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