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Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation

Although a limited number of L4 dorsal root ganglion neurons undergo minor injuries by L5 spinal nerve ligation, they are unlikely the major contributors to pathomechanisms. The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There are conflicting reports regarding the... Full description

Journal Title: Pain 2012, Vol.153(1), pp.68-79
Main Author: Fukuoka, Tetsuo
Other Authors: Yamanaka, Hiroki , Kobayashi, Kimiko , Okubo, Masamichi , Miyoshi, Kan , Dai, Yi , Noguchi, Koichi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0304-3959 ; E-ISSN: 1872-6623 ; DOI: 10.1016/j.pain.2011.09.009
Link: http://dx.doi.org/10.1016/j.pain.2011.09.009
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recordid: elsevier_sdoi_10_1016_j_pain_2011_09_009
title: Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation
format: Article
creator:
  • Fukuoka, Tetsuo
  • Yamanaka, Hiroki
  • Kobayashi, Kimiko
  • Okubo, Masamichi
  • Miyoshi, Kan
  • Dai, Yi
  • Noguchi, Koichi
subjects:
  • Neuropathic Pain Model
  • Spared Neuron
  • Sodium Channel
  • Brain-Derived Neurotrophic Factor
  • Neuropathic Pain Model
  • Spared Neuron
  • Sodium Channel
  • Brain-Derived Neurotrophic Factor
  • Medicine
ispartof: Pain, 2012, Vol.153(1), pp.68-79
description: Although a limited number of L4 dorsal root ganglion neurons undergo minor injuries by L5 spinal nerve ligation, they are unlikely the major contributors to pathomechanisms. The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) neurons in this model. If a significant number of these neurons were injured, the previously reported phenotypic and electrophysiological changes at this level are in need of re-evaluation by separating the injured neurons and the frankly spared ones. So, we immunostained activating transcription factor 3 (ATF3) and examined the change in expression of transcripts for neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF) and several voltage-gated sodium channel α-subunits (Nav1.1, Nav1.3, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) in the L4 DRG by comparing signal intensities of individual neurons using ...
language: eng
source:
identifier: ISSN: 0304-3959 ; E-ISSN: 1872-6623 ; DOI: 10.1016/j.pain.2011.09.009
fulltext: fulltext
issn:
  • 0304-3959
  • 03043959
  • 1872-6623
  • 18726623
url: Link


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titleRe-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation
creatorFukuoka, Tetsuo ; Yamanaka, Hiroki ; Kobayashi, Kimiko ; Okubo, Masamichi ; Miyoshi, Kan ; Dai, Yi ; Noguchi, Koichi
ispartofPain, 2012, Vol.153(1), pp.68-79
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subjectNeuropathic Pain Model ; Spared Neuron ; Sodium Channel ; Brain-Derived Neurotrophic Factor ; Neuropathic Pain Model ; Spared Neuron ; Sodium Channel ; Brain-Derived Neurotrophic Factor ; Medicine
descriptionAlthough a limited number of L4 dorsal root ganglion neurons undergo minor injuries by L5 spinal nerve ligation, they are unlikely the major contributors to pathomechanisms. The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) neurons in this model. If a significant number of these neurons were injured, the previously reported phenotypic and electrophysiological changes at this level are in need of re-evaluation by separating the injured neurons and the frankly spared ones. So, we immunostained activating transcription factor 3 (ATF3) and examined the change in expression of transcripts for neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF) and several voltage-gated sodium channel α-subunits (Nav1.1, Nav1.3, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) in the L4 DRG by comparing signal intensities of individual neurons using ...
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titleRe-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation
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Although a limited number of L4 dorsal root ganglion neurons undergo minor injuries by L5 spinal nerve ligation, they are unlikely the major contributors to pathomechanisms.

The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) neurons in this model. If a significant number of these neurons were injured, the previously reported phenotypic and electrophysiological changes at this level are in need of re-evaluation by separating the injured neurons and the frankly spared ones. So, we immunostained activating transcription factor 3 (ATF3) and examined the change in expression of transcripts for neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF) and several voltage-gated sodium channel α-subunits (Nav1.1, Nav1.3, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) in the L4 DRG by comparing signal intensities of individual neurons using ...

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abstract

Although a limited number of L4 dorsal root ganglion neurons undergo minor injuries by L5 spinal nerve ligation, they are unlikely the major contributors to pathomechanisms.

The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) neurons in this model. If a significant number of these neurons were injured, the previously reported phenotypic and electrophysiological changes at this level are in need of re-evaluation by separating the injured neurons and the frankly spared ones. So, we immunostained activating transcription factor 3 (ATF3) and examined the change in expression of transcripts for neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF) and several voltage-gated sodium channel α-subunits (Nav1.1, Nav1.3, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) in the L4 DRG by comparing signal intensities of individual neurons using ...

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