schliessen

Filtern

 

Bibliotheken

Irbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate

[Display omitted] ► IBS composite nanoparticles were prepared by using PVP/SDS as the stabilizer. ► PVP/SDS could significantly decrease the particle size to 55nm. ► The stability of drug nanoparticles is greatly enhanced by PVP/SDS. ► The composite nanoparticles showed a significant enhancement in... Full description

Journal Title: Particuology August 2012, Vol.10(4), pp.462-467
Main Author: Zhang, Zhiliang
Other Authors: Le, Yuan , Wang, Jiexin , Zhao, Hong , Chen, Jianfeng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1674-2001 ; E-ISSN: 2210-4291 ; DOI: 10.1016/j.partic.2012.01.002
Link: http://dx.doi.org/10.1016/j.partic.2012.01.002
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_partic_2012_01_002
title: Irbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate
format: Article
creator:
  • Zhang, Zhiliang
  • Le, Yuan
  • Wang, Jiexin
  • Zhao, Hong
  • Chen, Jianfeng
subjects:
  • Irbesartan
  • Composite Particles
  • Stabilizer
  • Dissolution Rate
  • Irbesartan
  • Composite Particles
  • Stabilizer
  • Dissolution Rate
  • Engineering
ispartof: Particuology, August 2012, Vol.10(4), pp.462-467
description: [Display omitted] ► IBS composite nanoparticles were prepared by using PVP/SDS as the stabilizer. ► PVP/SDS could significantly decrease the particle size to 55nm. ► The stability of drug nanoparticles is greatly enhanced by PVP/SDS. ► The composite nanoparticles showed a significant enhancement in dissolution rate. Irbesartan (IBS), an angiotensin II receptor antagonist, is a poorly water-soluble drug. To enhance the dissolution rate, IBS nanocomposite particles were produced via an anti-solvent precipitation combined with a spray drying process. Four pharmaceutically acceptable excipients, including three different polymers and one charged surfactant, were evaluated as stabilizers to control the particle size and to prevent the agglomeration of particles. The experiment results indicated that polyvinylpyrrolidone (PVP) combined with sodium dodecyl sulfate (SDS) significantly decreased the particle size and enhanced the stability of drug...
language: eng
source:
identifier: ISSN: 1674-2001 ; E-ISSN: 2210-4291 ; DOI: 10.1016/j.partic.2012.01.002
fulltext: no_fulltext
issn:
  • 1674-2001
  • 16742001
  • 2210-4291
  • 22104291
url: Link


@attributes
ID59447855
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_partic_2012_01_002
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_partic_2012_01_002
sourcesystemPC
dbid
0--K
1--M
2.~1
31B1
41~.
5457
64G.
77-5
88P~
9AAEDT
10AAEPC
11AAKOC
12AAOAW
13AAQFI
14ABNUV
15ABXRA
16ABYKQ
17ACDAQ
18ACRLP
19ADALY
20ADEWK
21AEKER
22AEZYN
23AFKWA
24AFTJW
25AGHFR
26AGUBO
27AGYEJ
28AHPOS
29AIKHN
30AITUG
31AJBFU
32AJOXV
33AMFUW
34BLXMC
35ENUVR
36EP2
37EP3
38FDB
39FIRID
40FNPLU
41GBLVA
42J1W
43KOM
44MAGPM
45OAUVE
46P-8
47P-9
48PC.
49Q38
50SDF
51SDG
52SES
53SPC
54SSG
55SSM
56SSZ
57T5K
58~G-
pqid1671329401
display
typearticle
titleIrbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate
creatorZhang, Zhiliang ; Le, Yuan ; Wang, Jiexin ; Zhao, Hong ; Chen, Jianfeng
ispartofParticuology, August 2012, Vol.10(4), pp.462-467
identifier
subjectIrbesartan ; Composite Particles ; Stabilizer ; Dissolution Rate ; Irbesartan ; Composite Particles ; Stabilizer ; Dissolution Rate ; Engineering
description[Display omitted] ► IBS composite nanoparticles were prepared by using PVP/SDS as the stabilizer. ► PVP/SDS could significantly decrease the particle size to 55nm. ► The stability of drug nanoparticles is greatly enhanced by PVP/SDS. ► The composite nanoparticles showed a significant enhancement in dissolution rate. Irbesartan (IBS), an angiotensin II receptor antagonist, is a poorly water-soluble drug. To enhance the dissolution rate, IBS nanocomposite particles were produced via an anti-solvent precipitation combined with a spray drying process. Four pharmaceutically acceptable excipients, including three different polymers and one charged surfactant, were evaluated as stabilizers to control the particle size and to prevent the agglomeration of particles. The experiment results indicated that polyvinylpyrrolidone (PVP) combined with sodium dodecyl sulfate (SDS) significantly decreased the particle size and enhanced the stability of drug...
languageeng
source
version4
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1016/j.partic.2012.01.002$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Zhang, Zhiliang
1Le, Yuan
2Wang, Jiexin
3Zhao, Hong
4Chen, Jianfeng
titleIrbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate
description

[Display omitted]

► IBS composite nanoparticles were prepared by using PVP/SDS as the stabilizer. ► PVP/SDS could significantly decrease the particle size to 55nm. ► The stability of drug nanoparticles is greatly enhanced by PVP/SDS. ► The composite nanoparticles showed a significant enhancement in dissolution rate.

Irbesartan (IBS), an angiotensin II receptor antagonist, is a poorly water-soluble drug. To enhance the dissolution rate, IBS nanocomposite particles were produced via an anti-solvent precipitation combined with a spray drying process. Four pharmaceutically acceptable excipients, including three different polymers and one charged surfactant, were evaluated as stabilizers to control the particle size and to prevent the agglomeration of particles. The experiment results indicated that polyvinylpyrrolidone (PVP) combined with sodium dodecyl sulfate (SDS) significantly decreased the particle size and enhanced the stability of drug...

subject
0Irbesartan
1Composite Particles
2Stabilizer
3Dissolution Rate
4Engineering
general
0English
1Elsevier B.V
210.1016/j.partic.2012.01.002
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_partic_2012_01_002
issn
01674-2001
116742001
22210-4291
322104291
rsrctypearticle
creationdate2012
addtitleParticuology
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.~1
31B1
41~.
5457
64G.
77-5
88P~
9AAEDT
10AAEPC
11AAKOC
12AAOAW
13AAQFI
14ABNUV
15ABXRA
16ABYKQ
17ACDAQ
18ACRLP
19ADALY
20ADEWK
21AEKER
22AEZYN
23AFKWA
24AFTJW
25AGHFR
26AGUBO
27AGYEJ
28AHPOS
29AIKHN
30AITUG
31AJBFU
32AJOXV
33AMFUW
34BLXMC
35ENUVR
36EP2
37EP3
38FDB
39FIRID
40FNPLU
41GBLVA
42J1W
43KOM
44MAGPM
45OAUVE
46P-8
47P-9
48PC.
49Q38
50SDF
51SDG
52SES
53SPC
54SSG
55SSM
56SSZ
57T5K
58~G-
startdate20120801
enddate20120831
lsr40Particuology, August 2012, Vol.10 (4), pp.462-467
doi10.1016/j.partic.2012.01.002
citationpf 462 pt 467 vol 10 issue 4
lsr30VSR-Enriched:[pqid]
sort
titleIrbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate
authorZhang, Zhiliang ; Le, Yuan ; Wang, Jiexin ; Zhao, Hong ; Chen, Jianfeng
creationdate20120800
lso0120120800
facets
frbrgroupid6067996170528657804
frbrtype5
newrecords20190904
languageeng
topic
0Irbesartan
1Composite Particles
2Stabilizer
3Dissolution Rate
4Engineering
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhang, Zhiliang
1Le, Yuan
2Wang, Jiexin
3Zhao, Hong
4Chen, Jianfeng
jtitleParticuology
creationdate2012
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
aulast
0Zhang
1Le
2Wang
3Zhao
4Chen
aufirst
0Zhiliang
1Yuan
2Jiexin
3Hong
4Jianfeng
auinitZ
auinit1Z
au
0Zhang, Zhiliang
1Le, Yuan
2Wang, Jiexin
3Zhao, Hong
4Chen, Jianfeng
atitleIrbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate
jtitleParticuology
risdate201208
volume10
issue4
spage462
epage467
pages462-467
issn1674-2001
eissn2210-4291
formatjournal
genrearticle
ristypeJOUR
abstract

[Display omitted]

► IBS composite nanoparticles were prepared by using PVP/SDS as the stabilizer. ► PVP/SDS could significantly decrease the particle size to 55nm. ► The stability of drug nanoparticles is greatly enhanced by PVP/SDS. ► The composite nanoparticles showed a significant enhancement in dissolution rate.

Irbesartan (IBS), an angiotensin II receptor antagonist, is a poorly water-soluble drug. To enhance the dissolution rate, IBS nanocomposite particles were produced via an anti-solvent precipitation combined with a spray drying process. Four pharmaceutically acceptable excipients, including three different polymers and one charged surfactant, were evaluated as stabilizers to control the particle size and to prevent the agglomeration of particles. The experiment results indicated that polyvinylpyrrolidone (PVP) combined with sodium dodecyl sulfate (SDS) significantly decreased the particle size and enhanced the stability of drug...

pubElsevier B.V
doi10.1016/j.partic.2012.01.002
lad01Particuology
date2012-08