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Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids

Higher docosahexaenoic acid (DHA) in females compared with males suggests ovarian hormones increase DHA production. Eight-week old rats were ovariectomized or sham operated (SHAM), and ovariectomized rats were treated with implanted pellets providing 17β-estradiol (OVX+E), progesterone (OVX+P), both... Full description

Journal Title: Prostaglandins Leukotrienes and Essential Fatty Acids (PLEFA), August 2013, Vol.89(2-3), pp.81-88
Main Author: Kitson, Alex P
Other Authors: Marks, Kristin A , Shaw, Brittany , Mutch, David M , Stark, Ken D
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0952-3278 ; E-ISSN: 1532-2823 ; DOI: 10.1016/j.plefa.2013.05.003
Link: http://dx.doi.org/10.1016/j.plefa.2013.05.003
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recordid: elsevier_sdoi_10_1016_j_plefa_2013_05_003
title: Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids
format: Article
creator:
  • Kitson, Alex P
  • Marks, Kristin A
  • Shaw, Brittany
  • Mutch, David M
  • Stark, Ken D
subjects:
  • Omega-3 Polyunsaturated Fatty Acids
  • Sex Hormones
  • Ovariectomy
  • Delta-6 Desaturase
  • Docosahexaenoic Acid
  • Omega-3 Polyunsaturated Fatty Acids
  • Sex Hormones
  • Ovariectomy
  • Delta-6 Desaturase
  • Docosahexaenoic Acid
  • Medicine
  • Anatomy & Physiology
ispartof: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), August 2013, Vol.89(2-3), pp.81-88
description: Higher docosahexaenoic acid (DHA) in females compared with males suggests ovarian hormones increase DHA production. Eight-week old rats were ovariectomized or sham operated (SHAM), and ovariectomized rats were treated with implanted pellets providing 17β-estradiol (OVX+E), progesterone (OVX+P), both (OVX+PE) or neither (OVX) for 14 days. Immunoblot and fatty acid analysis were performed on all samples, and microarray analysis was performed on OVX and SHAM groups. Increased Δ6-desaturase in OVX relative to SHAM was observed by microarray (12% higher) and immunoblot (31% higher). OVX+E and OVX+PE rats had 39% and 42% higher Δ6-desaturase content, respectively, compared with OVX. OVX+E and OVX+PE also increased phospholipid DHA concentrations in liver (increase of 34% and 40%, respectively) and plasma (increase of 70% and 74%, respectively) relative to OVX. Progesterone exerted no effect on Δ6-desaturase or DHA. These results indicate that 17β-estradiol increases DHA through increased...
language: eng
source:
identifier: ISSN: 0952-3278 ; E-ISSN: 1532-2823 ; DOI: 10.1016/j.plefa.2013.05.003
fulltext: fulltext
issn:
  • 0952-3278
  • 09523278
  • 1532-2823
  • 15322823
url: Link


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titleTreatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids
creatorKitson, Alex P ; Marks, Kristin A ; Shaw, Brittany ; Mutch, David M ; Stark, Ken D
ispartofProstaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), August 2013, Vol.89(2-3), pp.81-88
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subjectOmega-3 Polyunsaturated Fatty Acids ; Sex Hormones ; Ovariectomy ; Delta-6 Desaturase ; Docosahexaenoic Acid ; Omega-3 Polyunsaturated Fatty Acids ; Sex Hormones ; Ovariectomy ; Delta-6 Desaturase ; Docosahexaenoic Acid ; Medicine ; Anatomy & Physiology
descriptionHigher docosahexaenoic acid (DHA) in females compared with males suggests ovarian hormones increase DHA production. Eight-week old rats were ovariectomized or sham operated (SHAM), and ovariectomized rats were treated with implanted pellets providing 17β-estradiol (OVX+E), progesterone (OVX+P), both (OVX+PE) or neither (OVX) for 14 days. Immunoblot and fatty acid analysis were performed on all samples, and microarray analysis was performed on OVX and SHAM groups. Increased Δ6-desaturase in OVX relative to SHAM was observed by microarray (12% higher) and immunoblot (31% higher). OVX+E and OVX+PE rats had 39% and 42% higher Δ6-desaturase content, respectively, compared with OVX. OVX+E and OVX+PE also increased phospholipid DHA concentrations in liver (increase of 34% and 40%, respectively) and plasma (increase of 70% and 74%, respectively) relative to OVX. Progesterone exerted no effect on Δ6-desaturase or DHA. These results indicate that 17β-estradiol increases DHA through increased...
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Higher docosahexaenoic acid (DHA) in females compared with males suggests ovarian hormones increase DHA production. Eight-week old rats were ovariectomized or sham operated (SHAM), and ovariectomized rats were treated with implanted pellets providing 17β-estradiol (OVX+E), progesterone (OVX+P), both (OVX+PE) or neither (OVX) for 14 days. Immunoblot and fatty acid analysis were performed on all samples, and microarray analysis was performed on OVX and SHAM groups. Increased Δ6-desaturase in OVX relative to SHAM was observed by microarray (12% higher) and immunoblot (31% higher). OVX+E and OVX+PE rats had 39% and 42% higher Δ6-desaturase content, respectively, compared with OVX. OVX+E and OVX+PE also increased phospholipid DHA concentrations in liver (increase of 34% and 40%, respectively) and plasma (increase of 70% and 74%, respectively) relative to OVX. Progesterone exerted no effect on Δ6-desaturase or DHA. These results indicate that 17β-estradiol increases DHA through increased...

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Higher docosahexaenoic acid (DHA) in females compared with males suggests ovarian hormones increase DHA production. Eight-week old rats were ovariectomized or sham operated (SHAM), and ovariectomized rats were treated with implanted pellets providing 17β-estradiol (OVX+E), progesterone (OVX+P), both (OVX+PE) or neither (OVX) for 14 days. Immunoblot and fatty acid analysis were performed on all samples, and microarray analysis was performed on OVX and SHAM groups. Increased Δ6-desaturase in OVX relative to SHAM was observed by microarray (12% higher) and immunoblot (31% higher). OVX+E and OVX+PE rats had 39% and 42% higher Δ6-desaturase content, respectively, compared with OVX. OVX+E and OVX+PE also increased phospholipid DHA concentrations in liver (increase of 34% and 40%, respectively) and plasma (increase of 70% and 74%, respectively) relative to OVX. Progesterone exerted no effect on Δ6-desaturase or DHA. These results indicate that 17β-estradiol increases DHA through increased...

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doi10.1016/j.plefa.2013.05.003
lad01Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
date2013-08