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Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia

Controversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with insulin re... Full description

Journal Title: Psychiatry Research 30 December 2013, Vol.210(3), pp.825-829
Main Author: Chen, Song
Other Authors: Broqueres-You, Dong , Yang, Guigang , Wang, Zhiren , Li, Yanli , Wang, Ning , Zhang, Xiangyang , Yang, Fude , Tan, Yunlong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0165-1781 ; E-ISSN: 1872-7123 ; DOI: 10.1016/j.psychres.2013.08.056
Link: https://www.sciencedirect.com/science/article/pii/S0165178113005179
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recordid: elsevier_sdoi_10_1016_j_psychres_2013_08_056
title: Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia
format: Article
creator:
  • Chen, Song
  • Broqueres-You, Dong
  • Yang, Guigang
  • Wang, Zhiren
  • Li, Yanli
  • Wang, Ning
  • Zhang, Xiangyang
  • Yang, Fude
  • Tan, Yunlong
subjects:
  • Insulin Resistance
  • Dyslipidaemia
  • Antipsychotic-Naive First-Episode Psychosis Schizophrenia
  • Psychopathology
  • Medicine
ispartof: Psychiatry Research, 30 December 2013, Vol.210(3), pp.825-829
description: Controversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with insulin resistance and/or dyslipidaemia in Chinese patients with AN-FEP schizophrenia. A cross-sectional study was performed in Chinese patients newly diagnosed with schizophrenia ( 49, antipsychotic-naïve or antipsychotic medications< 2 weeks) and healthy volunteers ( 30). The serum levels of insulin and triglyceride levels as well as homeostasis model of assessment-insulin resistance (HOMA-IR) index were significantly increased in AN-FEP patients, when compared with healthy volunteers. The gender difference had a significant impact on the insulin resistance and dyslipidaemia in these AN-FEP subjects. Multiple linear regression analysis demonstrated...
language: eng
source:
identifier: ISSN: 0165-1781 ; E-ISSN: 1872-7123 ; DOI: 10.1016/j.psychres.2013.08.056
fulltext: fulltext
issn:
  • 0165-1781
  • 01651781
  • 1872-7123
  • 18727123
url: Link


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titleRelationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia
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ispartofPsychiatry Research, 30 December 2013, Vol.210(3), pp.825-829
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subjectInsulin Resistance ; Dyslipidaemia ; Antipsychotic-Naive First-Episode Psychosis Schizophrenia ; Psychopathology ; Medicine
descriptionControversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with insulin resistance and/or dyslipidaemia in Chinese patients with AN-FEP schizophrenia. A cross-sectional study was performed in Chinese patients newly diagnosed with schizophrenia ( 49, antipsychotic-naïve or antipsychotic medications< 2 weeks) and healthy volunteers ( 30). The serum levels of insulin and triglyceride levels as well as homeostasis model of assessment-insulin resistance (HOMA-IR) index were significantly increased in AN-FEP patients, when compared with healthy volunteers. The gender difference had a significant impact on the insulin resistance and dyslipidaemia in these AN-FEP subjects. Multiple linear regression analysis demonstrated...
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