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Up-regulated expression of PD-1 and its ligands during acute Classical Swine Fever virus infection in swine

•The roles of the PD-1/PD-Ls pathway during CSFV infection in swine are poorly understood.•The levels of PD-1 and its ligands mRNA were significantly increased in PBMCs during CSFV acute infection in swine.•Elevation of PD-1 and its ligands probably correlated with host immunosuppression during acut... Full description

Journal Title: Research in Veterinary Science October 2014, Vol.97(2), pp.251-256
Main Author: Yue, Feng
Other Authors: Zhu, Yan-Ping , Zhang, Yan-Fang , Sun, Guo-Peng , Yang, Yuan , Guo, Dong-Guang , Wang, Ai-Guo , Li, Bo-Wen , Yin, Mei , Cheng, An-Chun , Wang, Ming-Shu , Wang, Xuan-Nian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0034-5288 ; E-ISSN: 1532-2661 ; DOI: 10.1016/j.rvsc.2014.07.023
Link: http://dx.doi.org/10.1016/j.rvsc.2014.07.023
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recordid: elsevier_sdoi_10_1016_j_rvsc_2014_07_023
title: Up-regulated expression of PD-1 and its ligands during acute Classical Swine Fever virus infection in swine
format: Article
creator:
  • Yue, Feng
  • Zhu, Yan-Ping
  • Zhang, Yan-Fang
  • Sun, Guo-Peng
  • Yang, Yuan
  • Guo, Dong-Guang
  • Wang, Ai-Guo
  • Li, Bo-Wen
  • Yin, Mei
  • Cheng, An-Chun
  • Wang, Ming-Shu
  • Wang, Xuan-Nian
subjects:
  • Classical Swine Fever Virus
  • Programmed Death-1
  • Ligand
  • Peripheral Blood Mononucleur Cells
  • Swine
  • Classical Swine Fever Virus
  • Programmed Death-1
  • Ligand
  • Peripheral Blood Mononucleur Cells
  • Swine
  • Veterinary Medicine
ispartof: Research in Veterinary Science, October 2014, Vol.97(2), pp.251-256
description: •The roles of the PD-1/PD-Ls pathway during CSFV infection in swine are poorly understood.•The levels of PD-1 and its ligands mRNA were significantly increased in PBMCs during CSFV acute infection in swine.•Elevation of PD-1 and its ligands probably correlated with host immunosuppression during acute CSFV infection.•A novel mechanism of immunocompromised resulted by CSFV infection has been discovered. In order to investigate the relationship between the PD-1 pathway and impairment of immune responses with the CSFV infection, the mRNA expression of PD-1 and its ligands were evaluated by quantitative polymerase chain reaction (qPCR) during artificial CSFV infection. Simultaneously, expression of IL-2 and IL-10 mRNA were detected. The T cell proliferation and CSFV load in plasma were also measured. Results showed that the expression of PD-1 and its ligands mRNA were significantly increased (p  0.01) in PBMC from 3 to 7 days post infection (dpi). Meanwhile the...
language: eng
source:
identifier: ISSN: 0034-5288 ; E-ISSN: 1532-2661 ; DOI: 10.1016/j.rvsc.2014.07.023
fulltext: fulltext
issn:
  • 0034-5288
  • 00345288
  • 1532-2661
  • 15322661
url: Link


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titleUp-regulated expression of PD-1 and its ligands during acute Classical Swine Fever virus infection in swine
creatorYue, Feng ; Zhu, Yan-Ping ; Zhang, Yan-Fang ; Sun, Guo-Peng ; Yang, Yuan ; Guo, Dong-Guang ; Wang, Ai-Guo ; Li, Bo-Wen ; Yin, Mei ; Cheng, An-Chun ; Wang, Ming-Shu ; Wang, Xuan-Nian
ispartofResearch in Veterinary Science, October 2014, Vol.97(2), pp.251-256
identifier
subjectClassical Swine Fever Virus ; Programmed Death-1 ; Ligand ; Peripheral Blood Mononucleur Cells ; Swine ; Classical Swine Fever Virus ; Programmed Death-1 ; Ligand ; Peripheral Blood Mononucleur Cells ; Swine ; Veterinary Medicine
description•The roles of the PD-1/PD-Ls pathway during CSFV infection in swine are poorly understood.•The levels of PD-1 and its ligands mRNA were significantly increased in PBMCs during CSFV acute infection in swine.•Elevation of PD-1 and its ligands probably correlated with host immunosuppression during acute CSFV infection.•A novel mechanism of immunocompromised resulted by CSFV infection has been discovered. In order to investigate the relationship between the PD-1 pathway and impairment of immune responses with the CSFV infection, the mRNA expression of PD-1 and its ligands were evaluated by quantitative polymerase chain reaction (qPCR) during artificial CSFV infection. Simultaneously, expression of IL-2 and IL-10 mRNA were detected. The T cell proliferation and CSFV load in plasma were also measured. Results showed that the expression of PD-1 and its ligands mRNA were significantly increased (p  0.01) in PBMC from 3 to 7 days post infection (dpi). Meanwhile the...
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titleUp-regulated expression of PD-1 and its ligands during acute Classical Swine Fever virus infection in swine
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•The roles of the PD-1/PD-Ls pathway during CSFV infection in swine are poorly understood.•The levels of PD-1 and its ligands mRNA were significantly increased in PBMCs during CSFV acute infection in swine.•Elevation of PD-1 and its ligands probably correlated with host immunosuppression during acute CSFV infection.•A novel mechanism of immunocompromised resulted by CSFV infection has been discovered.

In order to investigate the relationship between the PD-1 pathway and impairment of immune responses with the CSFV infection, the mRNA expression of PD-1 and its ligands were evaluated by quantitative polymerase chain reaction (qPCR) during artificial CSFV infection. Simultaneously, expression of IL-2 and IL-10 mRNA were detected. The T cell proliferation and CSFV load in plasma were also measured. Results showed that the expression of PD-1 and its ligands mRNA were significantly increased (p < 0.01) in PBMC from 3 to 7 days post infection (dpi). Meanwhile the...

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•The roles of the PD-1/PD-Ls pathway during CSFV infection in swine are poorly understood.•The levels of PD-1 and its ligands mRNA were significantly increased in PBMCs during CSFV acute infection in swine.•Elevation of PD-1 and its ligands probably correlated with host immunosuppression during acute CSFV infection.•A novel mechanism of immunocompromised resulted by CSFV infection has been discovered.

In order to investigate the relationship between the PD-1 pathway and impairment of immune responses with the CSFV infection, the mRNA expression of PD-1 and its ligands were evaluated by quantitative polymerase chain reaction (qPCR) during artificial CSFV infection. Simultaneously, expression of IL-2 and IL-10 mRNA were detected. The T cell proliferation and CSFV load in plasma were also measured. Results showed that the expression of PD-1 and its ligands mRNA were significantly increased (p < 0.01) in PBMC from 3 to 7 days post infection (dpi). Meanwhile the...

pubElsevier Ltd
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date2014-10