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Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia

Converging evidence in schizophrenia points to disruption of the dopamine and glutamate neurotransmitter systems in the pathophysiology of the disorder. Dopamine is produced in the substantia nigra, but few neuroimaging studies have specifically targeted this structure. In fact, no studies of the su... Full description

Journal Title: Schizophrenia Research July 2013, Vol.147(2-3), pp.348-354
Main Author: Reid, Meredith A
Other Authors: Kraguljac, Nina V , Avsar, Kathy B , White, David M , Den Hollander, Jan A , Lahti, Adrienne C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0920-9964 ; E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2013.04.036
Link: https://www.sciencedirect.com/science/article/pii/S0920996413002363
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recordid: elsevier_sdoi_10_1016_j_schres_2013_04_036
title: Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia
format: Article
creator:
  • Reid, Meredith A
  • Kraguljac, Nina V
  • Avsar, Kathy B
  • White, David M
  • Den Hollander, Jan A
  • Lahti, Adrienne C
subjects:
  • Schizophrenia
  • Substantia Nigra
  • Magnetic Resonance Spectroscopy
  • Glutamate
  • N-Acetylaspartate
  • Cognition
ispartof: Schizophrenia Research, July 2013, Vol.147(2-3), pp.348-354
description: Converging evidence in schizophrenia points to disruption of the dopamine and glutamate neurotransmitter systems in the pathophysiology of the disorder. Dopamine is produced in the substantia nigra, but few neuroimaging studies have specifically targeted this structure. In fact, no studies of the substantia nigra in schizophrenia have used proton magnetic resonance spectroscopy (MRS). We sought to demonstrate the feasibility of acquiring single-voxel MRS measurements at 3 T from the substantia nigra and to determine which metabolites could be reliably quantified in schizophrenia patients and healthy controls. We used a turbo spin echo sequence with magnetization transfer contrast to visualize the substantia nigra and single-voxel proton MRS to quantify levels of -acetylaspartate, glutamate and glutamine (Glx), and choline in the left substantia nigra of 35 people with schizophrenia and 22 healthy controls. We...
language: eng
source:
identifier: ISSN: 0920-9964 ; E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2013.04.036
fulltext: fulltext
issn:
  • 0920-9964
  • 09209964
  • 1573-2509
  • 15732509
url: Link


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titleProton magnetic resonance spectroscopy of the substantia nigra in schizophrenia
creatorReid, Meredith A ; Kraguljac, Nina V ; Avsar, Kathy B ; White, David M ; Den Hollander, Jan A ; Lahti, Adrienne C
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subjectSchizophrenia ; Substantia Nigra ; Magnetic Resonance Spectroscopy ; Glutamate ; N-Acetylaspartate ; Cognition
descriptionConverging evidence in schizophrenia points to disruption of the dopamine and glutamate neurotransmitter systems in the pathophysiology of the disorder. Dopamine is produced in the substantia nigra, but few neuroimaging studies have specifically targeted this structure. In fact, no studies of the substantia nigra in schizophrenia have used proton magnetic resonance spectroscopy (MRS). We sought to demonstrate the feasibility of acquiring single-voxel MRS measurements at 3 T from the substantia nigra and to determine which metabolites could be reliably quantified in schizophrenia patients and healthy controls. We used a turbo spin echo sequence with magnetization transfer contrast to visualize the substantia nigra and single-voxel proton MRS to quantify levels of -acetylaspartate, glutamate and glutamine (Glx), and choline in the left substantia nigra of 35 people with schizophrenia and 22 healthy controls. We...
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