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Genetic liability, prenatal health, stress and family environment: Risk factors in the Harvard Adolescent Family High Risk for Schizophrenia Study

The familial (“genetic”) high-risk (FHR) paradigm enables assessment of individuals at risk for schizophrenia based on a positive family history of schizophrenia in first-degree, biological relatives. This strategy presumes genetic transmission of abnormal traits given high heritability of the illne... Full description

Journal Title: Schizophrenia Research August 2014, Vol.157(1-3), pp.142-148
Main Author: Walder, Deborah J
Other Authors: Faraone, Stephen V , Glatt, Stephen J , Tsuang, Ming T , Seidman, Larry J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0920-9964 ; E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2014.04.015
Link: http://dx.doi.org/10.1016/j.schres.2014.04.015
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recordid: elsevier_sdoi_10_1016_j_schres_2014_04_015
title: Genetic liability, prenatal health, stress and family environment: Risk factors in the Harvard Adolescent Family High Risk for Schizophrenia Study
format: Article
creator:
  • Walder, Deborah J
  • Faraone, Stephen V
  • Glatt, Stephen J
  • Tsuang, Ming T
  • Seidman, Larry J
subjects:
  • Stress
  • Psychosis
  • Relatives
  • Obstetric Complications
  • Neurodevelopment
  • Family Environment
  • Stress
  • Psychosis
  • Relatives
  • Obstetric Complications
  • Neurodevelopment
  • Family Environment
ispartof: Schizophrenia Research, August 2014, Vol.157(1-3), pp.142-148
description: The familial (“genetic”) high-risk (FHR) paradigm enables assessment of individuals at risk for schizophrenia based on a positive family history of schizophrenia in first-degree, biological relatives. This strategy presumes genetic transmission of abnormal traits given high heritability of the illness. It is plausible, however, that adverse environmental factors are also transmitted in these families. Few studies have evaluated both biological and environmental factors within a FHR study of adolescents. We conceptualize four precursors to psychosis pathogenesis: two biological (genetic predisposition, prenatal health issues (PHIs)) and two environmental (family environment, stressful life events (SLEs)). Participants assessed between 1998 and 2007 (ages 13–25) included 40 (20F/20M) adolescents at FHR for schizophrenia (FHRs) and 55 (31F/24M) community controls. ‘Genetic load’ indexed number of affected family members relative to pedigree size. PHI...
language: eng
source:
identifier: ISSN: 0920-9964 ; E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2014.04.015
fulltext: fulltext
issn:
  • 0920-9964
  • 09209964
  • 1573-2509
  • 15732509
url: Link


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titleGenetic liability, prenatal health, stress and family environment: Risk factors in the Harvard Adolescent Family High Risk for Schizophrenia Study
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subjectStress ; Psychosis ; Relatives ; Obstetric Complications ; Neurodevelopment ; Family Environment ; Stress ; Psychosis ; Relatives ; Obstetric Complications ; Neurodevelopment ; Family Environment
descriptionThe familial (“genetic”) high-risk (FHR) paradigm enables assessment of individuals at risk for schizophrenia based on a positive family history of schizophrenia in first-degree, biological relatives. This strategy presumes genetic transmission of abnormal traits given high heritability of the illness. It is plausible, however, that adverse environmental factors are also transmitted in these families. Few studies have evaluated both biological and environmental factors within a FHR study of adolescents. We conceptualize four precursors to psychosis pathogenesis: two biological (genetic predisposition, prenatal health issues (PHIs)) and two environmental (family environment, stressful life events (SLEs)). Participants assessed between 1998 and 2007 (ages 13–25) included 40 (20F/20M) adolescents at FHR for schizophrenia (FHRs) and 55 (31F/24M) community controls. ‘Genetic load’ indexed number of affected family members relative to pedigree size. PHI...
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The familial (“genetic”) high-risk (FHR) paradigm enables assessment of individuals at risk for schizophrenia based on a positive family history of schizophrenia in first-degree, biological relatives. This strategy presumes genetic transmission of abnormal traits given high heritability of the illness. It is plausible, however, that adverse environmental factors are also transmitted in these families. Few studies have evaluated both biological and environmental factors within a FHR study of adolescents.

We conceptualize four precursors to psychosis pathogenesis: two biological (genetic predisposition, prenatal health issues (PHIs)) and two environmental (family environment, stressful life events (SLEs)). Participants assessed between 1998 and 2007 (ages 13–25) included 40 (20F/20M) adolescents at FHR for schizophrenia (FHRs) and 55 (31F/24M) community controls. ‘Genetic load’ indexed number of affected family members relative to pedigree size.

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abstract

The familial (“genetic”) high-risk (FHR) paradigm enables assessment of individuals at risk for schizophrenia based on a positive family history of schizophrenia in first-degree, biological relatives. This strategy presumes genetic transmission of abnormal traits given high heritability of the illness. It is plausible, however, that adverse environmental factors are also transmitted in these families. Few studies have evaluated both biological and environmental factors within a FHR study of adolescents.

We conceptualize four precursors to psychosis pathogenesis: two biological (genetic predisposition, prenatal health issues (PHIs)) and two environmental (family environment, stressful life events (SLEs)). Participants assessed between 1998 and 2007 (ages 13–25) included 40 (20F/20M) adolescents at FHR for schizophrenia (FHRs) and 55 (31F/24M) community controls. ‘Genetic load’ indexed number of affected family members relative to pedigree size.

PHI...

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