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Altered serum levels of interleukin-3 in first-episode drug-naive and chronic medicated schizophrenia

Elevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode dr... Full description

Journal Title: Schizophrenia Research October 2016, Vol.176(2-3), pp.196-200
Main Author: Fu, Yin Yang
Other Authors: Zhang, Tong , Xiu, Mei Hong , Tang, Wei , Han, Mei , Yun, Long Tan , Chen, Da Chun , Chen, Song , Tan, Shu Ping , Soares, Jair C , Tang, Wen Jie , Zhang, Xiang Yang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0920-9964 ; E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2016.05.010
Link: http://dx.doi.org/10.1016/j.schres.2016.05.010
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recordid: elsevier_sdoi_10_1016_j_schres_2016_05_010
title: Altered serum levels of interleukin-3 in first-episode drug-naive and chronic medicated schizophrenia
format: Article
creator:
  • Fu, Yin Yang
  • Zhang, Tong
  • Xiu, Mei Hong
  • Tang, Wei
  • Han, Mei
  • Yun, Long Tan
  • Chen, Da Chun
  • Chen, Song
  • Tan, Shu Ping
  • Soares, Jair C
  • Tang, Wen Jie
  • Zhang, Xiang Yang
subjects:
  • Schizophrenia
  • Interleukin-3
  • Cytokines
  • Immune
  • Psychopathology
  • Schizophrenia
  • Interleukin-3
  • Cytokines
  • Immune
  • Psychopathology
ispartof: Schizophrenia Research, October 2016, Vol.176(2-3), pp.196-200
description: Elevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to chronic medicated patients with schizophrenia and examined the association of IL-3 with their psychopathological symptoms. Serum IL-3 levels were assessed in 55 FEDN patients, 52 chronic medicated patients and 43 healthy controls. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). Serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). We found significantly lower IL-3 levels in FEDN patients than both chronic patients and healthy controls (both p
language: eng
source:
identifier: ISSN: 0920-9964 ; E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2016.05.010
fulltext: fulltext
issn:
  • 0920-9964
  • 09209964
  • 1573-2509
  • 15732509
url: Link


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titleAltered serum levels of interleukin-3 in first-episode drug-naive and chronic medicated schizophrenia
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subjectSchizophrenia ; Interleukin-3 ; Cytokines ; Immune ; Psychopathology ; Schizophrenia ; Interleukin-3 ; Cytokines ; Immune ; Psychopathology
descriptionElevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to chronic medicated patients with schizophrenia and examined the association of IL-3 with their psychopathological symptoms. Serum IL-3 levels were assessed in 55 FEDN patients, 52 chronic medicated patients and 43 healthy controls. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). Serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). We found significantly lower IL-3 levels in FEDN patients than both chronic patients and healthy controls (both p<0.001), while IL-3 levels in chronic patients were markedly higher than in healthy controls. No significant association was observed between...
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Elevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to chronic medicated patients with schizophrenia and examined the association of IL-3 with their psychopathological symptoms. Serum IL-3 levels were assessed in 55 FEDN patients, 52 chronic medicated patients and 43 healthy controls. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). Serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). We found significantly lower IL-3 levels in FEDN patients than both chronic patients and healthy controls (both p<0.001), while IL-3 levels in chronic patients were markedly higher than in healthy controls. No significant association was observed between...

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Elevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to chronic medicated patients with schizophrenia and examined the association of IL-3 with their psychopathological symptoms. Serum IL-3 levels were assessed in 55 FEDN patients, 52 chronic medicated patients and 43 healthy controls. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). Serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). We found significantly lower IL-3 levels in FEDN patients than both chronic patients and healthy controls (both p<0.001), while IL-3 levels in chronic patients were markedly higher than in healthy controls. No significant association was observed between...

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